The international pictogram for chemicals that are sensitising, mutagenic, carcinogenic or toxic to reproduction
Reproductive toxicity refers to the potential risk from a given chemical, physical or biologic agent to adversely affect both male and female fertility as well as offspring development.[1] Reproductive toxicants may adversely affect sexual function, ovarian failure, fertility as well as causing developmental toxicity in the offspring.[2][3] Lowered effective fertility related to reproductive toxicity relates to both male and female effects alike and is reflected in decreased sperm counts, semen quality and ovarian failure.
^Occupational Health and Safety Administration. "Reproductive Hazards". osha.gov. Retrieved 6 February 2022.
^"Regulation (EC) No 1272/2008 of the EUROPEAN PARLIAMENT and of the COUNCIL". Official Journal of the European Union. 16 December 2008. Annex I, section 3.7 labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006.
^International Programme on Chemical Safety (2001). "Principles For Evaluating Health Risks To Reproduction Associated With Exposure To Chemicals". Environmental Health Criteria. 225. Geneva: World Health Organization.
and 25 Related for: Reproductive toxicity information
Reproductivetoxicity refers to the potential risk from a given chemical, physical or biologic agent to adversely affect both male and female fertility...
discharge or release a chemical known to the state to cause cancer or reproductivetoxicity into water" or into anywhere that feeds a drinking water source...
subcategories. Reproductivetoxicity includes adverse effects on sexual function and fertility in adult males and females, as well as developmental toxicity in offspring...
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on...
the EU as a Substance of very high concern (SVHC) because of its reproductivetoxicity. In 2014, the European Commission has started an investigation to...
requirements Part 3: Tests for genotoxicity, carcinogenicity and reproductivetoxicity Part 4: Selection of tests for interactions with blood Part 5: Tests...
European Union and certain phthalate esters have been shown to cause reproductivetoxicity in animal models. Formaldehyde is a colorless, strong smelling liquid...
Proposition 65 as a substance known to the state of California to cause reproductivetoxicity. The similar compound DINP is also listed. In 2013, ECHA's Risk...
toxic to birds, and to cause avian reproductivetoxicity. In bobwhite quail (Colinus virginianus), imidacloprid was determined to be moderately toxic...
cancers. Boric acid and borax are low in toxicity for acute oral exposures, at approximately the same acute toxicity as salt. The average dose for asymptomatic...
(NHANES). The main issue with phthalate exposure is typically male reproductivetoxicity, which is a risk that many phthalates share. A study conducted on...
has potential toxicity, with side effects occurring at some dose levels both when ingested and when applied topically. Although toxicity may be less when...
lapachol have been found to possess significant abortifacient and reproductivetoxicity effects for rats. Taheebo is the common name for the inner bark...
and Toxic Enforcement Act of 1986, commonly known as California Proposition 65, that are "known to the state to cause cancer or reproductivetoxicity" as...
of in vitro toxicity data and physiologically based kinetic modeling to predict dose–response curves for in vivo developmental toxicity of glycol ethers...
Reproductivetoxicity, categories 1A, 1B, 2 Specific target organ toxicity following single exposure, categories 1, 2 Specific target organ toxicity following...
of California, Chemicals known to the state to cause cancer or reproductivetoxicity, January 3, 2014" (PDF). Archived from the original (PDF) on 2014-01-10...
function changes, while repetitive doses lead to neurotoxicity. Reproductivetoxicity in males was also reported. A NOAEL in rodents was observed at 43μg/kg...
Chloroacetamide is toxic, irritates eyes and skin, and may cause an allergic reaction. It is suspected of reproductivetoxicity and teratogenicity. Novosphingobium...
2016. "Proposition 65 Maximum Allowable Daily Level (MADL) for ReproductiveToxicity for Cadmium (Oral Route)" (PDF). Retrieved 22 August 2016. Wikimedia...
de Cássia da Silveira E Sá R, de Oliveira Guerra M (July 2007). "Reproductivetoxicity of lapachol in adult male Wistar rats submitted to short-term treatment"...
available, including data on repeated dose toxicity, carcinogenicity, reproductivetoxicity, specific target organ toxicity, and repeated exposure. On February...
Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional...
In commercial use is the N,N'-diphenylethylenethiourea. Due to reproductivetoxicity, carcinogenicity, and mutagenicity, alternatives are being sought...
constipation, mucositis, anorexia, stomatitis, bone marrow toxicity (dose-limiting toxicity; may take 7–21 days to recover after the drug has been discontinued)...
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