Ranolazine, sold under the brand name Ranexa among others, is a medication used to treat heart related chest pain.[5] Typically it is used together with other medications when those are insufficient.[5][6] Therapeutic benefits appear smaller in females than males.[5] It is taken by mouth.[5]
Common side effects include constipation, headache, nausea, and dizziness.[5] Serious side effects may include QT prolongation.[5] Ranolazine is contraindicated (not recommended) in those with liver cirrhosis.[5] How it works is not clear but may involve adenosine triphosphate.[5]
Ranolazine was approved for medical use in the United States in 2006.[5] In 2021, it was the 202th most commonly prescribed medication in the United States, with more than 1million prescriptions.[7][8]
^"Prescription medicines: registration of new chemical entities in Australia, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 9 April 2023.
^"Prescription medicines and biologicals: TGA annual summary 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 31 March 2024.
^"Summary Basis of Decision (SBD) for Corzyna". Health Canada. 23 October 2014. Retrieved 29 May 2022.
^Jerling, M. (2006). Clinical pharmacokinetics of ranolazine. Clinical pharmacokinetics, 45, 469-491.
^ abcdefghi"Ranolazine Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 22 March 2019.
^British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 210. ISBN 9780857113382.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Atomoxetine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Ranolazine, sold under the brand name Ranexa among others, is a medication used to treat heart related chest pain. Typically it is used together with other...
cisapride, pimozide, astemizole, terfenadine, ergotamine, ticagrelor, ranolazine or dihydroergotamine is not recommended. It should not be used with colchicine...
inhibitors (statins), also is effective in many women, and new drugs, such as Ranolazine and Ivabradine, have shown promise in the treatment of MVA. Other approaches...
be used as antiparasitic drugs. Other examples include: Antianginals Ranolazine Trimetazidine Antidepressants Amoxapine Befuraline Buspirone Flesinoxan...
Fredj S, Sampson KJ, Liu H, Kass RS (May 2006). "Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action". British...
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