Protein-coding gene in humans
RUNX1T1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WQ6, 2DJ8, 2H7B, 2KYG, 2OD1, 2ODD, 2PP4, 4JOL
Identifiers Aliases RUNX1T1 , AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2, AML1-MTG8, t(8;21)(q22;q22), RUNX1 translocation partner 1, RUNX1 partner transcriptional co-repressor 1External IDs OMIM: 133435; MGI: 104793; HomoloGene: 3801; GeneCards: RUNX1T1; OMA:RUNX1T1 - orthologs Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.3 Start 91,954,967 bp[1] End 92,103,286 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A1|4 5.88 cM Start 13,743,436 bp[2] End 13,893,649 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sural nerve buccal mucosa cell tendon of biceps brachii Brodmann area 23 Achilles tendon paraflocculus of cerebellum middle temporal gyrus epithelium of colon parietal pleura
Top expressed in Rostral migratory stream secondary oocyte zygote internal carotid artery genital tubercle external carotid artery olfactory tubercle ascending aorta mammillary body lateral hypothalamus
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
DNA-binding transcription factor activity
DNA binding
protein binding
transcription corepressor activity
metal ion binding
Cellular component
nuclear matrix
nucleus
nucleoplasm
Biological process
negative regulation of fat cell differentiation
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
generation of precursor metabolites and energy
transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001198625 NM_001198626 NM_001198627 NM_001198628 NM_001198629 NM_001198630 NM_001198631 NM_001198632 NM_001198633 NM_001198634 NM_001198679 NM_004349 NM_175634 NM_175635 NM_175636 NM_001395209
NM_001111026 NM_001111027 NM_009822
RefSeq (protein) NP_001185554 NP_001185555 NP_001185556 NP_001185557 NP_001185558 NP_001185559 NP_001185560 NP_001185561 NP_001185562 NP_001185563 NP_001185608 NP_004340 NP_783552 NP_783553 NP_783554 NP_783553.1 NP_783554.1
NP_001104496 NP_001104497 NP_033952
Location (UCSC) Chr 8: 91.95 – 92.1 Mb Chr 4: 13.74 – 13.89 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.[5] [6] [7]
^ a b c GRCh38: Ensembl release 89: ENSG00000079102 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006586 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H (October 1992). "Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt". Blood . 80 (7): 1825–31. doi:10.1182/blood.V80.7.1825.1825 . PMID 1391946.
^ Calabi F, Cilli V (Dec 1998). "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family". Genomics . 52 (3): 332–341. doi:10.1006/geno.1998.5429. PMID 9790752.
^ "Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)".
Last Update: 2023-07-04T05:04:18Z
Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene. The protein encoded by this gene is a putative zinc finger transcription factor...
Word Count : 1732
Last Update: 2024-06-09T08:56:34Z
with recurrent genetic abnormalities AML with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 Acute promyelocytic...
Word Count : 2330
Last Update: 2023-08-31T05:42:04Z
thyristor, a semiconductor device Ethylene oxide, an organic compound RUNX1T1 , a gene Efforts to Outcomes, software produced by Social Solutions ETO-SZESE...
Word Count : 185
Last Update: 2024-06-21T23:44:03Z
translocations between chromosome 8 and 21 – [t(8;21)(q22;q22.1);] RUNX1-RUNX1T1 ; (ICD-O 9896/3); AML with inversions in chromosome 16 – [inv(16)(p13.1q22)]...
Word Count : 7249
Last Update: 2024-05-15T18:15:20Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 6709
Last Update: 2023-10-05T20:24:26Z
These translocations yield the formation of chimeric proteins (RUNX1-RUNX1T1 and PML-RARA, respectively) which disrupt normal myeloid precursor development...
Word Count : 605
Last Update: 2024-03-28T23:26:26Z
finger protein 5 pseudogene 1 RRS1: ribosome biogenesis regulator homolog RUNX1T1 : runt-related transcription factor 1; translocated to, 1 (cyclin D-related)...
Word Count : 1896
Last Update: 2023-11-30T20:16:11Z
myeloid leukemia is the formation of a fusion protein, AML1-ETO or RUNX1-RUNX1T1 , due to a translocation of chromosome 8 to chromosome 21 or t(8;21) (Miyoshi...
Word Count : 3160
Last Update: 2024-04-01T17:00:44Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 4469
Last Update: 2023-12-27T10:03:10Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 1999
Last Update: 2024-03-30T10:08:41Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 5880
Last Update: 2024-06-10T18:16:58Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 9500
Last Update: 2023-11-15T21:06:22Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 542
Last Update: 2024-05-26T23:45:53Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 7187
Last Update: 2024-05-09T09:39:54Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 1741
Last Update: 2024-05-20T07:08:45Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 3402
Last Update: 2024-06-26T16:49:14Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 1515
Last Update: 2024-04-18T00:25:38Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 6534
Last Update: 2022-06-03T20:14:44Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 593
Last Update: 2023-11-29T00:43:06Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 702
Last Update: 2024-06-19T02:23:16Z
BAG1, BAZ1B, CAV3, MED1, MED12, MED24, NCOR1, NCOR2, NCOA2, RXRA, RUNX1, RUNX1T1 , SNW1, STAT1, and ZBTB16. Click on genes, proteins and metabolites below...
Word Count : 2747
Last Update: 2022-10-13T20:18:05Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 126
Last Update: 2024-06-10T15:24:43Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 4825
Last Update: 2023-10-25T05:58:06Z
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 ...
Word Count : 2049