CooA is a heme-containing transcription factor that responds to the presence of carbon monoxide. This protein forms homodimers and is a homolog of cAMP receptor protein.[1] CooA regulates the expression of carbon monoxide dehydrogenase, an enzyme that catalyzes the oxidation of CO to CO2. The most well-studied CooA homolog comes from Rhodospirillum rubrum (RrCooA), but the CooA homolog from Carboxydothermus hydrogenoformans (ChCooA) has been studied as well.[2] The main difference between these two CooA homologs is the ferric heme coordination. For RrCooA, the ferric heme iron is bound to a cysteine and the amine of the N-terminal proline, while, in the ferrous state, a ligand switch occurs where a nearby histidine displaces the thiolate.[3][4][5] For ChCooA, the heme iron is ligated by a histidine and the N-terminal amine in both the ferric and ferrous states.[6] For both homologs, CO displaces the amine ligand and activates the protein to bind to its target DNA sequence.[7][8] Several structures of CooA exist: RrCooA in the ferrous state (1FT9),[9] ChCooA in the ferrous, imidazole-bound state (2FMY),[10] and ChCooA in the ferrous, CO-bound state (2HKX).[11]
^H. Körner; H. J. Sofia; W. G. Zumft (2003). "Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs". FEMS Microbiology Reviews. 27 (5): 559–592. doi:10.1016/S0168-6445(03)00066-4. PMID 14638413.
^T. Shimizu; D. Huang; F. Yan; M. Stranava; M. Bartosova; V. Fojtíková; M. Martínková (2015). "Gaseous O2, NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-Based Gas Sensors and Heme-Redox Sensors". Chem. Rev. 115 (13): 6491–6533. doi:10.1021/acs.chemrev.5b00018. PMID 26021768.
^Shelver, Daniel; Thorsteinsson, Marc V.; Kerby, Robert L.; Chung, Soo-Yeol; Roberts, Gary P.; Reynolds, Mark F.; Parks, Ryan B.; Burstyn, Judith N. (1999-03-01). "Identification of Two Important Heme Site Residues (Cysteine 75 and Histidine 77) in CooA, the CO-Sensing Transcription Factor of Rhodospirillum rubrum". Biochemistry. 38 (9): 2669–2678. doi:10.1021/bi982658j. ISSN 0006-2960. PMID 10052937.
^Dhawan, Ish K.; Shelver, Daniel; Thorsteinsson, Marc V.; Roberts, Gary P.; Johnson, Michael K. (1999-09-01). "Probing the Heme Axial Ligation in the CO-Sensing CooA Protein with Magnetic Circular Dichroism Spectroscopy". Biochemistry. 38 (39): 12805–12813. doi:10.1021/bi991303c. ISSN 0006-2960. PMID 10504250.
^Clark, Robert W.; Youn, Hwan; Parks, Ryan B.; Cherney, Melisa M.; Roberts, Gary P.; Burstyn, Judith N. (2004-11-01). "Investigation of the Role of the N-Terminal Proline, the Distal Heme Ligand in the CO Sensor CooA". Biochemistry. 43 (44): 14149–14160. doi:10.1021/bi0487948. ISSN 0006-2960. PMID 15518565.
^Inagaki, Sayaka; Masuda, Chiaki; Akaishi, Tetsuhiro; Nakajima, Hiroshi; Yoshioka, Shiro; Ohta, Takehiro; Pal, Biswajit; Kitagawa, Teizo; Aono, Shigetoshi (February 2005). "Spectroscopic and Redox Properties of a CooA Homologue from Carboxydothermus hydrogenoformans". Journal of Biological Chemistry. 280 (5): 3269–3274. doi:10.1074/jbc.m409884200. ISSN 0021-9258. PMID 15537640.
^G. P. Roberts; R. L. Kerby; H. Youn; M. Conrad (2005). "CooA, A Paradigm for Gas Sensing Regulatory Proteins". J. Inorg. Biochem. 99 (1): 280–92. doi:10.1016/j.jinorgbio.2004.10.032. PMID 15598507.
^Shigetoshi Aono (2003). "Biochemical and Biophysical Properties of the CO-Sensing Transcriptional Activator CooA". Acc. Chem. Res. 36 (11): 825–31. doi:10.1021/ar020097p. PMID 14622029.
^Lanzilotta, William N.; Schuller, David J.; Thorsteinsson, Marc V.; Kerby, Robert L.; Roberts, Gary P.; Poulos, Thomas L. (October 2000). "Structure of the CO sensing transcription activator CooA". Nature Structural Biology. 7 (10): 876–880. doi:10.1038/82820. ISSN 1545-9985. PMID 11017196. S2CID 26285016.
^Borjigin, M.; Li, H.; Lanz, N. D.; Kerby, R. L.; Roberts, G. P.; Poulos, T. L. (2007-03-01). "Structure-based hypothesis on the activation of the CO-sensing transcription factor CooA". Acta Crystallographica Section D: Biological Crystallography. 63 (3): 282–287. Bibcode:2007AcCrD..63..282B. doi:10.1107/S0907444906051638. ISSN 0907-4449. PMID 17327664.
(RrCooA), but the CooA homolog from Carboxydothermus hydrogenoformans (ChCooA) has been studied as well. The main difference between these two CooA homologs...
Look up COO or coo in Wiktionary, the free dictionary. COO or coo may refer to: Certificate of origin, used in international trade Chief operating officer...
CooCoo may refer to: Film Princess Coo-Coo, a character in the 1977 John Waters film Desperate Living Literature CooCoo Comics, a comic book published...
Calvin Bellamy (born July 4, 1970), better known as CooCoo Cal, is an American rapper and truck driver from Milwaukee, Wisconsin. His single "My Projects"...
Coos, Lower Umpqua and Siuslaw Indians, federally recognized tribe of Coos people Coös County, New Hampshire Coos Bay, Oregon, a small city on Coos Bay...
Look up Coor in Wiktionary, the free dictionary. Coor or COOR may refer to: Lattie F. Coor (born 1936), American academic Coor Crags, a landform in Antarctica...
Clifton Burton "CooCoo" Marlin (January 3, 1932 – August 14, 2005) was a NASCAR Winston Cup driver who spent 14 years in the series. Marlin earned a...
Coos people are an indigenous people of the Northwest Plateau, living in Oregon. They live on the southwest Oregon Pacific coast. Today, Coos people are...
Coos County is the name of two counties in the United States: Coös County, New Hampshire Coos County, Oregon This disambiguation page lists articles about...
The CooCoo Nut Grove is a 1936 Warner Bros. Merrie Melodies short animated film, set in the famed Cocoanut Grove of the Ambassador Hotel in Los Angeles...
Coos Bay is an estuary where the Coos River enters the Pacific Ocean, the estuary is approximately 12 miles long and up to two miles wide. It is the largest...
The Turra Coo (Doric for "the Turriff Cow") was a white Ayrshire-Shorthorn cross dairy cow which lived near the Aberdeenshire town of Turriff in north-east...
Bill and Coo is a 1948 film directed by Dean Riesner, filmed in Trucolor, and conceived to showcase George Burton's trained birds (Burton's Birds). The...
A chief operating officer (COO) (or chief operations officer) is an executive in charge of the daily operations of an organization (i.e. personnel, resources...
Plopsa Coo is a themepark in Wallonia near the waterfalls of Coo in Stavelot, owned and operated by Plopsa. The history of the park starts in the 15th...
The Coos River flows for about 5 miles (8.0 km) into Coos Bay along the Pacific coast of southwest Oregon in the United States. Formed by the confluence...
Marilyn McCoo (born September 30, 1943) is an American singer, actress, and television presenter, who is best known for being the lead female vocalist...
Olivia "Bong" Coo (born June 3, 1948) is a Filipino sports administrator and retired professional bowler. She is regarded as the most decorated Filipino...
Gertrude Marianne Achenbach Coor (1915 - 1962) was a German-American art historian. Gertrude Achenbach grew up in Frankfurt. In 1933, she moved to Italy...
International Port of Coos Bay is a port of the Pacific coast of the United States, located in Coos Bay near the city of Coos Bay, Oregon. It is the...
Couscous (Arabic: كُسْكُس, romanized: kuskus) is a traditional North African dish of small steamed granules of rolled semolina that is often served with...
McCoo is a surname. Notable people with the surname include: Eric McCoo (born 1980), American football player Marilyn McCoo (born 1943), American singer...
Merrisa Campbell, known by her recording alias Cooly G, is a British singer, rapper, producer and DJ, living in London. She has released two albums of...
Coixtlahuaca (Chocho: Nguichee; Mixtec: Yodzocoo; Nahuatl: Coaixtlahuacan) was a pre-Columbian Mesoamerican state in the Mixteca Alta (now in Oaxaca, Mexico)...
CooRie is a self-produced Japanese music unit by singer-songwriter Rino that performs songs for anime and games. CooRie used to be a two-person unit when...
The Highland (Scottish Gaelic: Bò Ghàidhealach; Scots: Heilan coo) is a Scottish breed of rustic cattle. It originated in the Scottish Highlands and the...