SPI1 information

SPI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PUE
Identifiers
Aliases	SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10
External IDs	OMIM: 165170; MGI: 98282; HomoloGene: 2346; GeneCards: SPI1; OMA:SPI1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,378,547 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	90,946,101 bp
RNA expression pattern
	Top expressed in
	monocyte; ; right lung; ; upper lobe of left lung; ; spleen; ; blood; ; bone marrow cells; ; appendix; ; right coronary artery; ; lymph node; ; gallbladder;
	Top expressed in
	spleen; ; blood; ; lip; ; ankle joint; ; subcutaneous adipose tissue; ; body of femur; ; right lung lobe; ; calvaria; ; white adipose tissue; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity; NFAT protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding;
Cellular component	nucleus; nucleoplasm; transcription regulator complex;
Biological process	myeloid leukocyte differentiation; regulation of transcription, DNA-templated; cellular response to ethanol; somatic stem cell population maintenance; lymphocyte differentiation; regulation of erythrocyte differentiation; myeloid dendritic cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of MHC class II biosynthetic process; lymphoid progenitor cell differentiation; transcription, DNA-templated; macrophage differentiation; anatomical structure regression; negative regulation of histone H4 acetylation; negative regulation of gene expression, epigenetic; vasculature development; granulocyte differentiation; apoptotic process involved in blood vessel morphogenesis; histone H3 acetylation; erythrocyte differentiation; hypermethylation of CpG island; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; pri-miRNA transcription by RNA polymerase II; cell differentiation; interleukin-6-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6688
	20375
	ENSG00000066336
	ENSMUSG00000002111
	P17947
	P17433
	NM_001080547; NM_003120
	NM_011355; NM_001378898; NM_001378899
	NP_001074016; NP_003111
	NP_035485; NP_001365827; NP_001365828
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000066336 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002111 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ray D, Culine S, Tavitain A, Moreau-Gachelin F (May 1990). "The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors". Oncogene. 5 (5): 663–668. PMID 1693183.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000066336 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002111 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1693183-5] Ray D, Culine S, Tavitain A, Moreau-Gachelin F (May 1990). "The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors". Oncogene. 5 (5): 663–668. PMID 1693183.

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