RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger RNA (mRNA). It works by removing all the introns (non-coding regions of RNA) and splicing back together exons (coding regions). For nuclear-encoded genes, splicing occurs in the nucleus either during or immediately after transcription. For those eukaryotic genes that contain introns, splicing is usually needed to create an mRNA molecule that can be translated into protein. For many eukaryotic introns, splicing occurs in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs). There exist self-splicing introns, that is, ribozymes that can catalyze their own excision from their parent RNA molecule. The process of transcription, splicing and translation is called gene expression, the central dogma of molecular biology.
methods of RNAsplicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur...
Alternative splicing, or alternative RNAsplicing, or differential splicing, is an alternative splicing process during gene expression that allows a single...
hESCs by ensuring genes undergo RNAsplicing to create a mature RNA transcript. The SON gene is required for RNAsplicing of transcripts encoding the cell-cycle...
Exon mRNA Eukaryotic chromosome fine structure Small t intron Splicing: Alternative splicing Exitron Minor spliceosome Outron Function MicroRNA Others:...
Small nuclear RNA (snRNA) is a class of small RNA molecules that are found within the splicing speckles and Cajal bodies of the cell nucleus in eukaryotic...
the protein product. The spliceosome, a protein-RNA complex located in the nucleus, catalyzes splicing in the following manner: The spliceosome recognizes...
generally not considered. (For that, see Proteoforms.) Through RNAsplicing mechanisms, mRNA has the ability to select different protein-coding segments...
defective RNA. Splicing ribozymes catalyze RNAsplicing, removing a section of RNA that contains a mutation and replacing it with well-functioning RNA. Existing...
3'-polyadenylation, and alternative splicing. In particular, alternative splicing directly contributes to the diversity of mRNA found in cells. The modifications...
fellowship, she was instrumental in the research that led to the discovery of RNAsplicing and split genes, which awarded Sharp the 1993 Nobel Prize in Physiology...
to be removed after transcription through a process termed RNAsplicing. Splicing of RNA transcripts requires a highly precise and coordinated sequence...
director for the final cut. However, sometimes the RNA within the intron acts as a ribozyme, splicing itself without the use of a spliceosome or protein...
process, RNAsplicing removes the non-coding RNA introns leaving behind the exons, which are then spliced and joined together to form the mature mRNA. Splicing...
(ribonucleic acid enzymes) are RNA molecules that have the ability to catalyze specific biochemical reactions, including RNAsplicing in gene expression, similar...
transfer RNA (tRNA), microRNA (miRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), Piwi-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA)...
process of RNAsplicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read...
Transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides...
can also modify the splicing of pre-mRNA or inhibit the maturation and activity of miRNA. Techniques for targeting Morpholinos to RNAs and delivering Morpholinos...
organization of the gene-expression machinery splicing snRNPs and other splicing proteins necessary for pre-mRNA processing. Because of a cell's changing requirements...
molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional...
(ATP) or guanosine triphosphate (GTP). Normally, splicing is associated only with pre-mRNAsplicing. This precursor protein contains three segments—an...
alternative pre-mRNAsplicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. SR proteins alternatively splice pre-mRNA by preferentially...
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