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Osteoimmunology information


Osteoimmunology (όστέον, osteon from Greek, "bone"; immunitas from Latin, "immunity"; and λόγος, logos, from Greek "study") is a field that emerged about 40 years ago that studies the interface between the skeletal system and the immune system,[1][2] comprising the "osteo-immune system".[3][4] Osteoimmunology also studies the shared components and mechanisms between the two systems in vertebrates, including ligands, receptors, signaling molecules and transcription factors. Over the past decade, osteoimmunology has been investigated clinically for the treatment of bone metastases, rheumatoid arthritis (RA), osteoporosis, osteopetrosis, and periodontitis. Studies in osteoimmunology reveal relationships between molecular communication among blood cells and structural pathologies in the body.[5]

  1. ^ Arron JR, Choi Y (November 2000). "Bone versus immune system". Nature. 408 (6812): 535–6. doi:10.1038/35046196. PMID 11117729. S2CID 32822431.
  2. ^ Walsh MC, Kim N, Kadono Y, Rho J, Lee SY, Lorenzo J, Choi Y (2006). "Osteoimmunology: interplay between the immune system and bone metabolism". Annual Review of Immunology. 24: 33–63. doi:10.1146/annurev.immunol.24.021605.090646. PMID 16551243.
  3. ^ Lorenzo J, Horowitz M, Choi Y (June 2008). "Osteoimmunology: interactions of the bone and immune system". Endocrine Reviews. 29 (4): 403–40. doi:10.1210/er.2007-0038. PMC 2528852. PMID 18451259.
  4. ^ Lorenzo J, Choi Y (December 2005). "Osteoimmunology". Immunological Reviews. 208: 5–6. doi:10.1111/j.0105-2896.2005.00340.x. PMID 16313336. S2CID 221814630.
  5. ^ McHugh KP (April 2008). "Osteoimmunology in skeletal cell biology and disease". Autoimmunity. 41 (3): 181–2. doi:10.1080/08916930701694808. PMID 18365830. S2CID 22159566.

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Osteoimmunology

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