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Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.
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Pyrimidineanalogues are antimetabolites which mimic the structure of metabolic pyrimidines. Nucleobase analogues Fluorouracil (5FU), which inhibits thymidylate...
of cytosine, uracil, and thymine is derived of pyrimidine, so those three bases are called the pyrimidine bases. Each of the base pairs in a typical double-helix...
pregnancy is safe for the baby. Flucytosine is in the fluorinated pyrimidineanalogue family of medications. It works by being converted into fluorouracil...
Azathioprine, Thiopurines, and Fludarabine pyrimidineanalogues – mimic the structure of metabolic pyrimidines, the smaller bases incorporated into DNA...
PMID 18761442. Greco NJ, Tor Y (August 2005). "Simple fluorescent pyrimidineanalogues detect the presence of DNA abasic sites". Journal of the American...
The purine bases adenine and guanine and pyrimidine base cytosine occur in both DNA and RNA, while the pyrimidine bases thymine (in DNA) and uracil (in RNA)...
Purine analogues are antimetabolites that mimic the structure of metabolic purines. Nucleobase analogues Thiopurines such as thioguanine are used to treat...
(purines) differs from the synthesis of CTP, TTP, and UTP (pyrimidines). Both purine and pyrimidine synthesis use phosphoribosyl pyrophosphate (PRPP) as a...
include: folic acid analogues, such as methotrexate purine analogues, such as azathioprine and mercaptopurine pyrimidineanalogues, such as fluorouracil...
demethylated form of thymine. Uracil is a common and naturally occurring pyrimidine derivative. The name "uracil" was coined in 1885 by the German chemist...
Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidineanalogue used as an antineoplastic agent. It is a derivative of fluorouracil...
Gemcitabine is structurally similar to cytarabine and functions as a pyrimidineanalogue, and blocks the progression of cells through the G1/S-phase. Gemcitabine...
the UMP within the active site until it is reacted to yield TMP. Pyrimidineanalogues Thymidylate synthase inhibitor Thymidine kinase Thymidine kinase...
linked through a glycosidic bond to the N9 of a purine or the N1 of a pyrimidine. Nucleotides are the molecular building blocks of DNA and RNA. This list...
inhibitors (NIs), non-nucleoside allosteric inhibitors, and pyrophosphate analogues. Subsequently, all three classes are then subclassified. All inhibit RNA...
formula C5H5N5O, guanine is a derivative of purine, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. This unsaturated arrangement...
pregnancy may harm the fetus. Fluorouracil is in the antimetabolite and pyrimidine analog families of medications. How it works is not entirely clear, but...
ethoxymethylenemalononitrile (1) with acetamidine (2) affords the substituted pyrimidine (4). The reaction may well involve conjugate addition of the amidine nitrogen...
maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside...
brewer's yeast, as well as pyrimidine-rich foods such as beer. During digestion, RNA-rich foods are broken-down into ribosyl pyrimidines (cytidine and uridine)...
as deoxythymidine, deoxyribosylthymine, or thymine deoxyriboside, is a pyrimidine deoxynucleoside. Deoxythymidine is the DNA nucleoside T, which pairs with...
PMID 25387551. Gish RG (January 2006). "Treating HCV with ribavirin analogues and ribavirin-like molecules". The Journal of Antimicrobial Chemotherapy...
and pyrimidine moieties are biosynthesized separately and are then combined to form ThMP by the action of thiamine-phosphate synthase. The pyrimidine ring...
2-aminouracil is a pyrimidine base that is an isomer of cytosine. It is used in combination with isoguanine in studies of unnatural nucleic acid analogues of the...
T. (2007). "Highly Stable Pyrimidine-Motif Triplex Formation at Physiological pH Values by a Bridged Nucleic Acid Analogue". Angewandte Chemie International...
between carbonyl group in position 17 on the D-ring and amino group on the pyrimidine ring of +1 cytosine. CPT is selectively cytotoxic to the cells replicating...
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