translation repressor activity, mRNA regulatory element binding
sequence-specific mRNA binding
Cellular component
cytoplasm
cytosol
membrane
mitochondrial matrix
nucleolus
mitochondrion
mitochondrial inner membrane
nucleus
Biological process
response to cytokine
nucleotide biosynthetic process
DNA biosynthetic process
response to organic cyclic compound
response to progesterone
tetrahydrofolate interconversion
human ageing
response to glucocorticoid
regulation of transcription involved in G1/S transition of mitotic cell cycle
dTTP biosynthetic process
tetrahydrofolate metabolic process
response to vitamin A
cartilage development
methylation
developmental growth
response to organophosphorus
circadian rhythm
uracil metabolic process
dTMP biosynthetic process
intestinal epithelial cell maturation
dUMP metabolic process
response to folic acid
response to ethanol
response to toxic substance
pyrimidine nucleobase metabolic process
regulation of translation
liver regeneration
nucleobase-containing small molecule interconversion
negative regulation of translation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7298
22171
Ensembl
ENSG00000176890
ENSMUSG00000025747
UniProt
P04818 Q53Y97
P07607
RefSeq (mRNA)
NM_001071 NM_001354867 NM_001354868
NM_021288
RefSeq (protein)
NP_001062 NP_001341796 NP_001341797 NP_001062.1
NP_067263
Location (UCSC)
Chr 18: 0.66 – 0.67 Mb
Chr 5: 30.26 – 30.28 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
thymidylate synthase
Thymidylate synthase homodimer, Human
Identifiers
EC no.
2.1.1.45
CAS no.
9031-61-2
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
AmiGO / QuickGO
Search
PMC
articles
PubMed
articles
NCBI
proteins
Thymidylate synthase
Identifiers
Symbol
Thymidylat_synt
Pfam
PF00303
InterPro
IPR000398
PROSITE
PDOC00086
SCOP2
1tys / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Thymidylate synthase (TS) (EC 2.1.1.45)[5] is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage.[6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000176890 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025747 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: TYMS thymidylate synthetase".
^"DNA: Form and Function" (PDF). Archived from the original (PDF) on 2013-05-25. Retrieved 2014-05-02.
^"DNA Synthesis".
and 29 Related for: Thymidylate synthase information
Thymidylatesynthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate...
Thymidylatesynthase inhibitors are chemical agents which inhibit the enzyme thymidylatesynthase and have potential as an anticancer chemotherapy. This...
antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylatesynthase, and is manufactured by AstraZeneca. Used in treatment of colorectal...
(where uracil is used instead), inhibition of thymidine synthesis via thymidylatesynthase selectively inhibits DNA synthesis over RNA synthesis. Due to their...
entirely clear, but it is believed to involve blocking the action of thymidylatesynthase and thus stopping the production of DNA. Fluorouracil was patented...
methyl group onto the uracil base of dUMP to generate dTMP. The thymidylatesynthase reaction, dUMP + 5,10-methylenetetrahydrofolate ⇔ dTMP + dihydrofolate...
It bypasses several metabolic steps in the body and better binds thymidylatesynthase with FdUMP, a metabolite of the drug fluorouracil. In March 2012...
inhibited. Methotrexate, therefore, inhibits the synthesis of DNA, RNA, thymidylates, and proteins. For the treatment of rheumatoid arthritis, inhibition...
with the alpha-subunit of tryptophan (TSA) synthase to yield indole. The beta-subunit of tryptophan synthase (TSB) catalyzes condensation of indole with...
aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylatesynthase". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease...
are primarily DHFR inhibitors, but raltitrexed is an inhibitor of thymidylatesynthase, and pemetrexed inhibits both and a third enzyme. Antifolates act...
therefore also inhibits DNA synthesis. It primarily inhibits the enzyme thymidylatesynthase, but also has effects on DHFR, aminoimidazole carboxamide ribonucleotide...
5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylatesynthase (TS). By inhibiting the deoxynucleotide biosynthesis, FdUMP stops...
targets. One of the important targets for cellular reproduction is thymidylatesynthase, which creates thymidine monophosphate (TMP) from deoxyuridine monophosphate...
microscopy when prepared slide has a sample transversely dissected. Thymidylatesynthase, the enzyme used to generate thymidine monophosphate Tourette syndrome...
Global Information
