Purine analogue information

Purine analogues are antimetabolites that mimic the structure of metabolic purines. Nucleobase analogues Thiopurines such as thioguanine are used to treat...

resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues". The Biochemical Journal. 361 (Pt 3): 497–503. doi:10.1042/0264-6021:3610497...

include: folic acid analogues, such as methotrexate purine analogues, such as azathioprine and mercaptopurine pyrimidine analogues, such as fluorouracil...

DNA production is halted and the cell dies. purine analogues – mimic the structure of metabolic purines, the larger bases incorporated into DNA as adenosine...

the fluorescent 2-amino-6-(2-thienyl)purine and pyrrole-2-carbaldehyde. In medicine, several nucleoside analogues are used as anticancer and antiviral...

active forms of relapsing-remitting multiple sclerosis. Cladribine is a purine analogue that selectively targets and suppresses lymphocytes implicated in the...

blood clots, lymphopenia, hepatotoxicity and infections. Azathioprine Purine analogue that inhibits lymphocyte proliferation via conversion to mercaptopurine...

pregnancy may result in harm to the baby. Azathioprine belongs to the purine analogues subclass of antimetabolites family of medications. It works via 6-thioguanine...

archaically xanthic acid; systematic name 3,7-dihydropurine-2,6-dione) is a purine base found in most human body tissues and fluids, as well as in other organisms...

chemists who were working at the Burroughs Wellcome Co. in Tuckahoe, many purine analogues were tested, culminating in the discovery of 6-mercaptopurine (6-MP)...

novo. The synthesis of ATP and GTP (purines) differs from the synthesis of CTP, TTP, and UTP (pyrimidines). Both purine and pyrimidine synthesis use phosphoribosyl...

Fludarabine is a purine analogue and antineoplastic agent. It is generally used as its 5-O-phosphorylated form known as fludarabine phosphate, sold under...

Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular...

injury. Xanthine oxidase inhibitors are of two kinds: purine analogues and others. Purine analogues include allopurinol, oxypurinol, and tisopurine. Others...

linked. Purines, however, are first synthesized from the sugar template onto which the ring synthesis occurs. For reference, the syntheses of the purine and...

Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines. Nucleobase analogues Fluorouracil (5FU), which inhibits thymidylate...

Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor (Pentostatin) Halogenated/ribonucleotide reductase...

John D.; Epner, Elliot M. (2009-08-01). "Cladribine: not just another purine analogue?". Expert Opinion on Investigational Drugs. 18 (8): 1169–1181. doi:10...

the anomeric carbon is linked through a glycosidic bond to the N9 of a purine or the N1 of a pyrimidine. Nucleotides are the molecular building blocks...

treatments have been attempted, with limited success in certain people: purine analogues (pentostatin, fludarabine, cladribine), chlorambucil, and various forms...

transplantation and autoimmune diseases belonging to the chemical class of purine analogues, also known by the brand name Imuran, has been reported to be effective...

rituximab) FCR (fludarabine, cyclophosphamide, and rituximab) Although the purine analogue fludarabine was shown to give superior response rates to chlorambucil...

Tioguanine is in the antimetabolite family of medications. It is a purine analogue of guanine and works by disrupting DNA and RNA. Tioguanine was developed...

Rebetol. Ribavirin is possibly best viewed as a ribosyl purine analogue with an incomplete purine 6-membered ring. This structural resemblance historically...

inhibition of phosphodiesterase. Caffeine is a bitter, white crystalline purine, a methylxanthine alkaloid, and is chemically related to the adenine and...

The molecular formula C5H4N4 may refer to: Purine Purine analogues 5-Aza-7-deazapurine Pyridine analogues Triazolopyridine 4-azidopyridine This set index...

called guanosine. With the formula C5H5N5O, guanine is a derivative of purine, consisting of a fused pyrimidine-imidazole ring system with conjugated...