ABCC11, ATP-binding cassette, sub-family C (CFTR/MRP), member 11, EWWD, MRP8, WW, ATP binding cassette subfamily C member 11, ATP-binding cassette transporter sub-family C member 1
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ATP-binding cassette transporter sub-family C member 11, also MRP8 (Multidrug Resistance-Related Protein 8), is a membrane transporter that exports certain molecules from inside a cell. It is a protein that in humans is encoded by gene ABCC11.[3][4][5]
The gene is responsible for determination of human cerumen type (wet or dry ear wax) and presence of underarm osmidrosis (odor associated with sweat caused by excessive apocrine secretion), and is associated with colostrum secretion.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000121270 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, et al. (Jul 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene. 273 (1): 89–96. doi:10.1016/S0378-1119(01)00572-8. PMID 11483364.
^Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Research. 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397. S2CID 9528197.
^Cite error: The named reference entrez was invoked but never defined (see the help page).
^Miura K, Yoshiura Ki, Miura S, Shimada T, Yamasaki K, Yoshida A, et al. (June 2007). "A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland". Human Genetics. 121 (5): 631–633. doi:10.1007/s00439-007-0356-9. ISSN 0340-6717. PMID 17394018. S2CID 575882.
molecules from inside a cell. It is a protein that in humans is encoded by gene ABCC11. The gene is responsible for determination of human cerumen type (wet or...
to prevent inbreeding. The ABCC11 gene determines axillary body odor and the type of earwax. The loss of a functional ABCC11 gene is caused by a 538G>A...
T, Ninokata A, Ishikawa T, Kaname T, et al. (March 2006). "A SNP in the ABCC11 gene is the determinant of human earwax type". Nature Genetics. 38 (3):...
secretions and normal skin microflora. In addition, androstane steroids and the ABCC11 transporter are essential for most axillary odor. Body odor is a complex...
(AASI) as well as to Australasians. The majority of East Asians have the ABCC11 gene (80-95%), which greatly reduces body odor and codes for dry-type earwax...
T, Ninokata A, Ishikawa T, Kaname T, et al. (March 2006). "A SNP in the ABCC11 gene is the determinant of human earwax type". Nature Genetics. 38 (3):...
EDAR allele commonly found in modern East Asian populations, the derived ABCC11 allele associated with dry earwax and reduced body odor commonly found in...
are relatively small, these differences in certain genes such as duffy, ABCC11, SLC24A5, called ancestry-informative markers (AIMs) nevertheless can be...
research group identified a single nucleotide polymorphism (SNP) in the ABCC11 gene is the determinant of human earwax type. Niikawa obtained his medical...
new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene. 273 (1): 89–96...
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