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Primase information


Toprim domain
Identifiers
SymbolToprim
PfamPF01751
Pfam clanToprim-like
InterProIPR006171
SCOP22fcj / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Toprim catalytic core
Identifiers
SymbolToprim_N
PfamPF08275
InterProIPR013264
SCOP21dd9 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
AEP DNA primase, small subunit
Identifiers
SymbolDNA_primase_S
PfamPF01896
Pfam clanAEP
InterProIPR002755
SCOP21g71 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
AEP DNA primase, large subunit
Identifiers
SymbolDNA_primase_lrg
PfamPF04104
Pfam clanCL0242
InterProIPR007238
SCOP21zt2 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

DNA primase is an enzyme involved in the replication of DNA and is a type of RNA polymerase. Primase catalyzes the synthesis of a short RNA (or DNA in some living organisms[1]) segment called a primer complementary to a ssDNA (single-stranded DNA) template. After this elongation, the RNA piece is removed by a 5' to 3' exonuclease and refilled with DNA.

  1. ^ Bocquier AA, Liu L, Cann IK, Komori K, Kohda D, Ishino Y (March 2001). "Archaeal primase: bridging the gap between RNA and DNA polymerases". Current Biology. 11 (6): 452–6. doi:10.1016/s0960-9822(01)00119-1. PMID 11301257.

and 26 Related for: Primase information

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Primase

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DNA primase is an enzyme involved in the replication of DNA and is a type of RNA polymerase. Primase catalyzes the synthesis of a short RNA (or DNA in...

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Okazaki fragments

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creating what is known as the DNA replication fork. Following this fork, DNA primase and DNA polymerase begin to act in order to create a new complementary...

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DNA replication

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helix. The preinitiation complex also loads α-primase and other DNA polymerases onto the DNA. After α-primase synthesizes the first primers, the primer-template...

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DNA polymerase alpha

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α-DNA primase complex) consists of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits...

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DnaG

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DnaG is a bacterial DNA primase and is encoded by the dnaG gene. The enzyme DnaG, and any other DNA primase, synthesizes short strands of RNA known as...

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Amenamevir

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(herpes zoster). It acts as an inhibitor of the zoster virus's helicase–primase complex. Amenamevir was approved in Japan for the treatment of shingles...

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Pritelivir

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inhibition of the viral helicase primase complex, encoded by the UL5 (helicase), UL8 (scaffold protein) and UL52 (primase) genes, which is essential for...

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Polymerase

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different superfamily (InterPro: IPR043519). Primases generally don't fall into either category. Bacterial primases usually have the Toprim domain, and are...

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Replisome

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proteins including helicase, RFC, PCNA, gyrase/topoisomerase, SSB/RPA, primase, DNA polymerase III, RNAse H, and DNA ligase. For prokaryotes, each dividing...

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PRIM2

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DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene. The replication of DNA in eukaryotic cells is carried out by a complex...

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PRIM1

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DNA primase small subunit is an enzyme that in humans is encoded by the PRIM1 gene. The replication of DNA in eukaryotic cells is carried out by a complex...

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Magnesium acetate

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been found to cause a conformational change in Escherichia coli enzyme Primase. In this experiment Mg(OAc)2, MnCl2, CaCl2, NaOAc, LiCl, MgSO4 and MgCl2...

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DNA polymerase I

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initiated by a short RNA segment, known as RNA primer, synthesized by Primase in the 5' to 3' direction. DNA synthesis then occurs by the addition of...

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Kinetoplast

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replication proteins including an endonuclease, helicase, DNA polymerase, DNA primase, and DNA ligase, which initiate repair of remaining discontinuities in...

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De novo synthesis

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involves cloning the genes into plasmids into Escherichia coli or yeast. Primase is an RNA polymerase, and it can add a primer to an existing strand awaiting...

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Primosome

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during DNA replication. The primosome consists of seven proteins: DnaG primase, DnaB helicase, DnaC helicase assistant, DnaT, PriA, Pri B, and PriC. At...

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RNA polymerase

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column. And also combinations of the above techniques. Alpha-amanitin Primase Werner F, Grohmann D (February 2011). "Evolution of multisubunit RNA polymerases...

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Eukaryotic DNA replication

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synthesis, polymerase α (Pol α) acts as a replicative primase. Pol α is associated with an RNA primase and this complex accomplishes the priming task by synthesizing...

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DNA polymerase

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α-DNA primase complex) consists of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits...

Word Count : 7053

B virus

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dUTPase, ribonucleotide reductase, DNA polymerase, DNA helicase, DNA primase, and protein kinases. The B virus genome was fully sequenced in 2003 from...

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Herpes simplex virus

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P89430 Virion maturation UL8 DNA helicase/primase complex-associated protein P10192 P89431 DNA virus helicase-primase complex-associated protein UL9 Replication...

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DNA polymerase alpha catalytic subunit

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gene. This gene encodes the p180 catalytic subunit of DNA polymerase α-primase. Pol α has limited processivity and lacks 3′ exonuclease activity for proofreading...

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T7 DNA polymerase

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replication. In T7 system, primase domain of one subunit interacts with primase domain of adjacent subunit. This interaction between primase domains acts as a...

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DNA polymerase III holoenzyme

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primer, complementary to part of the single-stranded DNA, is synthesized by primase (an RNA polymerase):[citation needed] ("!" for RNA, '"$" for DNA, "*" for...

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ColE1

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by DNA polymerase I. Lagging strand synthesis is later initiated by a primase encoded by the host cell. Replication is carried out entirely by host proteins...

Word Count : 392

Purine analogue

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Nucleotide analogues Fludarabine inhibits multiple DNA polymerases, DNA primase, and DNA ligase I, and is S phase-specific (since these enzymes are highly...

Word Count : 186

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