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Portal hypertension information


Portal hypertension
The portal vein and its tributaries
SpecialtyGastroenterology
SymptomsAscites[1]
CausesSplenic vein thrombosis, stenosis of portal vein [2]
Diagnostic methodUltrasonography[2]
TreatmentPortosystemic shunts, Nonselective beta-blockers[2]

Portal hypertension is defined as increased portal venous pressure, with a hepatic venous pressure gradient greater than 5 mmHg.[3][4] Normal portal pressure is 1–4 mmHg; clinically insignificant portal hypertension is present at portal pressures 5–9 mmHg; clinically significant portal hypertension is present at portal pressures greater than 10 mmHg.[5] The portal vein and its branches supply most of the blood and nutrients from the intestine to the liver.[6]

Cirrhosis (a form of chronic liver failure) is the most common cause of portal hypertension; other, less frequent causes are therefore grouped as non-cirrhotic portal hypertension. The signs and symptoms of both cirrhotic and non-cirrhotic portal hypertension are often similar depending on cause, with patients presenting with abdominal swelling due to ascites, vomiting of blood, and lab abnormalities such as elevated liver enzymes or low platelet counts.

Treatment is directed towards decreasing portal hypertension itself or in the management of its acute and chronic complications.[7] Complications include ascites, spontaneous bacterial peritonitis, variceal hemorrhage, hepatic encephalopathy, hepatorenal syndrome, and cardiomyopathy.

  1. ^ Cite error: The named reference patient was invoked but never defined (see the help page).
  2. ^ a b c Cite error: The named reference emed was invoked but never defined (see the help page).
  3. ^ D'Souza D. "Portal hypertension". Radiopaedia. Retrieved 11 March 2021.
  4. ^ "Portal hypertension | Disease | Overview". rarediseases.info.nih.gov. Retrieved 2016-01-08.
  5. ^ Kibrit J, Khan R, Jung BH, Koppe S (August 2018). "Clinical Assessment and Management of Portal Hypertension". Seminars in Interventional Radiology. 35 (3): 153–159. doi:10.1055/s-0038-1660793. PMC 6078702. PMID 30087517.
  6. ^ "Portal Hypertension - Liver and Gallbladder Disorders". MSD Manual Consumer Version. Retrieved 11 March 2021.
  7. ^ Kulkarni AV, Rabiee A, Mohanty A (July 2022). "Management of Portal Hypertension". Journal of Clinical and Experimental Hepatology. 12 (4): 1184–1199. doi:10.1016/j.jceh.2022.03.002. PMC 9257868. PMID 35814519.

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lower third of the esophagus. They are most often a consequence of portal hypertension, commonly due to cirrhosis. People with esophageal varices have a...

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pressure is termed portal hypertension, and has numerous sequelae such as ascites and hepatic encephalopathy. WHVP is used to estimate the portal venous pressure...

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had venomous snakes in place of hair. It is also a sign of portal hypertension. When the portal vein, that transfers the blood from the gastrointestinal...

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Portal hypertensive gastropathy refers to changes in the mucosa of the stomach in patients with portal hypertension; by far the most common cause of this...

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symptoms, leading to portal hypertension before it is diagnosed. Other symptoms can develop based on the cause. For example, if portal vein thrombosis develops...

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intrahepatic vascular resistance and so may be of therapeutic benefit in portal hypertension. An open label phase IIa clinical study is under way.[when?][citation...

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of the rectum. Typically this occurs due to portal hypertension which shunts venous blood from the portal system through the portosystemic anastomosis...

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communication between the inflow portal vein and the outflow hepatic vein. It is used to treat portal hypertension (which is often due to liver cirrhosis)...

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destroyed in the spleen. Other common causes include congestion due to portal hypertension and infiltration by leukemias and lymphomas. Thus, the finding of...

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Epoxyeicosatrienoic acid

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neuroinflammation, Portal hypertension or hypertension in the venous hepatic portal system of blood flow is defined as an increase in portal pressure above...

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Hepatic portal system

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the average cardiac output at rest. Portal hypertension is a condition in which the blood pressure of the portal venous system is too high. It is often...

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Hemorrhoid

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due to portal hypertension (blood pressure in the portal venous system) may present similar to hemorrhoids but are a different condition. Portal hypertension...

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Ascites

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1 g/dL) indicates the ascites is due to portal hypertension. A low gradient (< 1.1 g/dL) indicates ascites of non-portal hypertensive as a cause. Ultrasound...

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anastomoses from portal hypertension Pulmonary Schistosomiasis due to portosystemic anastomoses from portal hypertension Portal hypertension secondary to...

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