Platelet transfusion refractoriness is the repeated failure to achieve the desired level of blood platelets in a patient following a platelet transfusion. The cause of refractoriness may be either immune or non-immune. Among immune-related refractoriness, antibodies against HLA antigens are the primary cause. Non-immune causes include splenomegaly (enlargement of the spleen), fever, and sepsis.[1][2]
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Colman, Robert W.; Marder, Victor J.; Clowes, Alexander W.; George, James N.; Goldhaber, Samuel Z. (2005), Hemostasis and Thrombosis: Basic Principles and Clinical Practice (5th ed.), Lippincott Williams & Wilkins, p. 1195, ISBN 978-0-7817-4996-1
^Stanworth, Simon J.; Navarrete, Cristina; Estcourt, Lise; Marsh, Judith (2015). "Platelet refractoriness – practical approaches and ongoing dilemmas in patient management". British Journal of Haematology. 171 (3): 297–305. doi:10.1111/bjh.13597. ISSN 1365-2141. PMID 26194869. S2CID 9379017.
and 28 Related for: Platelet transfusion refractoriness information
Platelettransfusionrefractoriness is the repeated failure to achieve the desired level of blood platelets in a patient following a platelet transfusion...
to demonstrate an adequate post-transfusion increment, this is termed platelettransfusionrefractoriness. Platelets, either apheresis-derived or random-donor...
characterized by abnormally low levels of platelets (also known as thrombocytes) in the blood. Low levels of platelets in turn may lead to prolonged or excessive...
cases of platelettransfusionrefractoriness to infusion of donor platelets. A nomenclature was devised by International Society of Blood Transfusion (ISBT)...
cytopenias are bleeding (due to lack of platelets) or infection (due to lack of white blood cells). Long-term transfusion of packed red blood cells leads to...
may also be refractory as a manifestation of gastrointestinal problems which disrupt iron absorption or cause occult bleeding. Transfusion dependent anemia...
remedies. Platelettransfusion alone is normally not recommended except in an emergency and is usually unsuccessful in producing a long-term platelet count...
Immunosuppressants, such as glucocorticoids, and rituximab may also be used. Platelettransfusions are generally not recommended. About 1 per 100,000 people are affected...
activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system (HPA15), implicated in refractoriness to platelettransfusion, neonatal...
multiple platelettransfusions, continued to exhibit low platelet levels. This condition is known as refractoriness to platelettransfusion. Subsequent...
the equivalent of between six and ten random platelet concentrates. Quality control demands the platelets from apheresis be equal to or greater than 3...
2015). "Comparison of different platelet count thresholds to guide administration of prophylactic platelettransfusion for preventing bleeding in people...
with the red blood cell histogram shifted to the left. Leukocytes and platelets are normal. Bone marrow shows erythroid hyperplasia with a maturation...
(ed.). "Comparison of different platelet count thresholds to guide administration of prophylactic platelettransfusion for preventing bleeding in people...
(ed.). "Comparison of different platelet count thresholds to guide administration of prophylactic platelettransfusion for preventing bleeding in people...
and megakaryocytes, the latter cells responsible for the production of platelets. Signs and symptoms include fever, night sweats, bone pain, fatigue, and...
application of granulocyte colony stimulating factor (G-CSF) or granulocyte transfusion and the use of broad-spectrum antibiotics to protect against bacterial...
pronounced effect in reducing mitral regurgitation Patients will need dual anti-platelet therapy for 6 months or more. Within the next 6 months, patients will need...
inhibitor of the protein-protein interaction between fibrinogen and the platelet integrin receptor GP IIb/IIIa and is the first drug candidate whose origins...
2015). "Comparison of different platelet count thresholds to guide administration of prophylactic platelettransfusion for preventing bleeding in people...
due to a lack of red blood cells, or easy bleeding due to a low platelet count. Platelet function may be somewhat impaired in HCL patients, although this...
spherocytosis (in cases of direct Coombs test, DCT, positive haemolytic anaemia). Platelet counts may be reduced, increased or normal. Haemoglobin levels are usually...
Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with...
considered a medical emergency. Fluid replacement, as well as blood transfusion, may be required. Endoscopy is recommended within 24 hours and bleeding...
decrease white blood cells counts, two percent more patients decrease platelets counts, one percent more patients get severe infections (4.5% for patients...
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