Human platelet antigens (HPA) are polymorphisms in platelet antigens. These can stimulate production of alloantibodies (that is, antibodies against other people's antigens) in recipients of transfused platelets from donors with different HPAs. These antibodies cause neonatal alloimmune thrombocytopenia, post-transfusion purpura, and some cases of platelet transfusion refractoriness to infusion of donor platelets.[1]
^Metcalfe P, Watkins N, Ouwehand W, Kaplan C, Newman P, Kekomaki R, De Haas M, Aster R, Shibata Y, Smith J, Kiefel V, Santoso S (2003). "Nomenclature of human platelet antigens". Vox Sang. 85 (3): 240–5. doi:10.1046/j.1423-0410.2003.00331.x. PMID 14516468. S2CID 27653273.
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