CD36 information

CD36
Identifiers
Aliases	CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, CD36 molecule
External IDs	OMIM: 173510 MGI: 107899 HomoloGene: 73871 GeneCards: CD36
Gene location (Human)
Chr.	Chromosome 7 (human)
End	80,679,277 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	18,093,799 bp
RNA expression pattern
	Top expressed in
	abdominal fat; ; monocyte; ; jejunal mucosa; ; right ventricle; ; subcutaneous adipose tissue; ; vena cava; ; trabecular bone; ; duodenum; ; gallbladder; ; spleen;
	Top expressed in
	right lung; ; right lung lobe; ; left lung; ; left lung lobe; ; intercostal muscle; ; right ventricle; ; digastric muscle; ; atrioventricular valve; ; white adipose tissue; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; low-density lipoprotein particle receptor activity; transforming growth factor beta binding; high-density lipoprotein particle binding; lipoprotein particle binding; thrombospondin receptor activity; lipid binding; low-density lipoprotein particle binding; lipoteichoic acid immune receptor activity; amyloid-beta binding; scavenger receptor activity; Toll-like receptor binding; oxidised low-density lipoprotein particle receptor activity; protein-containing complex binding;
Cellular component	Golgi apparatus; apical plasma membrane; phagocytic vesicle; apical part of cell; brush border membrane; endocytic vesicle membrane; integral component of plasma membrane; membrane; external side of plasma membrane; integral component of membrane; platelet alpha granule membrane; membrane raft; cell surface; plasma membrane; extracellular space; specific granule membrane; intracellular anatomical structure; receptor complex;
Biological process	low-density lipoprotein particle mediated signaling; apoptotic cell clearance; positive regulation of MAPK cascade; response to lipid; nitric oxide mediated signal transduction; intestinal absorption; positive regulation of blood microparticle formation; positive regulation of blood coagulation; plasma lipoprotein particle clearance; sensory perception of taste; blood coagulation; cellular response to hydroperoxide; positive regulation of ERK1 and ERK2 cascade; receptor internalization; cellular response to bacterial lipopeptide; amyloid fibril formation; cellular response to lipopolysaccharide; cell surface receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cholesterol transport; platelet degranulation; cholesterol import; cellular response to diacyl bacterial lipopeptide; negative regulation of transcription by RNA polymerase II; transport; toll-like receptor TLR6:TLR2 signaling pathway; phagocytosis, recognition; cellular response to low-density lipoprotein particle stimulus; positive regulation of macrophage cytokine production; immune response; response to linoleic acid; negative regulation of gene expression; positive regulation of reactive oxygen species metabolic process; lipoprotein transport; positive regulation of cell-matrix adhesion; positive regulation of interleukin-12 production; triglyceride transport; long-chain fatty acid import into cell; MyD88-dependent toll-like receptor signaling pathway; response to fatty acid; regulation of removal of superoxide radicals; cellular response to lipoteichoic acid; positive regulation of cholesterol storage; intestinal cholesterol absorption; positive regulation of tumor necrosis factor production; receptor-mediated endocytosis; lipid metabolism; cGMP-mediated signaling; positive regulation of phagocytosis, engulfment; defense response to Gram-positive bacterium; positive regulation of cytosolic calcium ion concentration; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; response to stilbenoid; positive regulation of NLRP3 inflammasome complex assembly; low-density lipoprotein particle clearance; lipid storage; positive regulation of macrophage derived foam cell differentiation; cell adhesion; toll-like receptor signaling pathway; neutrophil degranulation; regulation of lipid metabolic process; production of molecular mediator involved in inflammatory response; fatty acid metabolic process; phagocytosis, engulfment; response to bacterium; positive regulation of gene expression; positive regulation of cell death; cytokine-mediated signaling pathway; regulation of lipopolysaccharide-mediated signaling pathway; regulation of toll-like receptor signaling pathway; negative regulation of protein import into nucleus; regulation of protein heterodimerization activity; positive regulation of nitric oxide biosynthetic process; positive regulation of NF-kappaB transcription factor activity; energy homeostasis; regulation of action potential; positive regulation of cold-induced thermogenesis; cellular response to oxidised low-density lipoprotein particle stimulus; oxidised low-density lipoprotein particle clearance; amyloid-beta clearance by cellular catabolic process; positive regulation of reactive oxygen species biosynthetic process; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	948
	12491
	ENSG00000135218
	ENSMUSG00000002944
	P16671
	Q08857
NM_000072; NM_001001547; NM_001001548; NM_001127443; NM_001127444;
	NM_001289908; NM_001289909; NM_001289911; NM_001371074; NM_001371075; NM_001371077; NM_001371078; NM_001371079; NM_001371080; NM_001371081
	NM_001159555; NM_001159556; NM_001159557; NM_001159558; NM_007643
NP_000063; NP_001001547; NP_001001548; NP_001120915; NP_001120916;
	NP_001276837; NP_001276838; NP_001276840; NP_001358003; NP_001358004; NP_001358006; NP_001358007; NP_001358008; NP_001358009; NP_001358010
	NP_001153027; NP_001153028; NP_001153029; NP_001153030; NP_031669
	Wikidata
View/Edit Human	View/Edit Mouse

CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral membrane protein found on the surface of many cell types in vertebrate animals. It imports fatty acids inside cells and is a member of the class B scavenger receptor family of cell surface proteins. CD36 binds many ligands including collagen,^[5] thrombospondin,^[6] erythrocytes parasitized with Plasmodium falciparum,^[7] oxidized low density lipoprotein,^[8]^[9] native lipoproteins,^[10] oxidized phospholipids,^[11] and long-chain fatty acids.^[12]

Work in genetically modified rodents suggest a role for CD36 in fatty acid metabolism,^[13]^[14]^[15] heart disease,^[16] taste,^[17]^[18]^[19] and dietary fat processing in the intestine.^[20] It may be involved in glucose intolerance, atherosclerosis, arterial hypertension, diabetes, cardiomyopathy, Alzheimer's disease and various cancers, mostly of epithelial origin (breast, prostate, ovary, and colon) and also for hepatic carcinoma and gliomas.^[21]^[22]^[23]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135218 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002944 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tandon NN, Kralisz U, Jamieson GA (May 1989). "Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion". The Journal of Biological Chemistry. 264 (13): 7576–83. doi:10.1016/S0021-9258(18)83273-2. PMID 2468670.
^ Silverstein RL, Baird M, Lo SK, Yesner LM (August 1992). "Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor". The Journal of Biological Chemistry. 267 (23): 16607–12. doi:10.1016/S0021-9258(18)42046-7. PMID 1379600.
^ Oquendo P, Hundt E, Lawler J, Seed B (July 1989). "CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes". Cell. 58 (1): 95–101. doi:10.1016/0092-8674(89)90406-6. PMID 2473841. S2CID 22059108.
^ Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA (June 1993). "CD36 is a receptor for oxidized low density lipoprotein". The Journal of Biological Chemistry. 268 (16): 11811–6. doi:10.1016/S0021-9258(19)50272-1. PMID 7685021.
^ Nicholson AC, Frieda S, Pearce A, Silverstein RL (February 1995). "Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site". Arteriosclerosis, Thrombosis, and Vascular Biology. 15 (2): 269–75. doi:10.1161/01.ATV.15.2.269. PMID 7538425.
^ Calvo D, Gómez-Coronado D, Suárez Y, Lasunción MA, Vega MA (April 1998). "Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL". Journal of Lipid Research. 39 (4): 777–88. doi:10.1016/S0022-2275(20)32566-9. PMID 9555943.^{[permanent dead link]}
^ Podrez EA, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, et al. (October 2002). "Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36". The Journal of Biological Chemistry. 277 (41): 38503–16. doi:10.1074/jbc.M203318200. PMID 12105195.
^ Baillie AG, Coburn CT, Abumrad NA (September 1996). "Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homolog". The Journal of Membrane Biology. 153 (1): 75–81. doi:10.1007/s002329900111. PMID 8694909. S2CID 5911289.
^ Hajri T, Han XX, Bonen A, Abumrad NA (May 2002). "Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice". The Journal of Clinical Investigation. 109 (10): 1381–9. doi:10.1172/JCI14596. PMC 150975. PMID 12021254.
^ Pravenec M, Landa V, Zídek V, Musilová A, Kazdová L, Qi N, et al. (2003). "Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension" (PDF). Physiological Research. 52 (6): 681–8. doi:10.33549/physiolres.930380. PMID 14640889.
^ Mistry JJ, Bowles KM, Rushworth SA (December 2021). "Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection". Nature Communications. 12 (1): 7130. Bibcode:2021NatCo..12.7130M. doi:10.1038/s41467-021-27460-9. PMC 8655073. PMID 34880245.
^ Febbraio M, Podrez EA, Smith JD, Hajjar DP, Hazen SL, Hoff HF, et al. (April 2000). "Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice". The Journal of Clinical Investigation. 105 (8): 1049–56. doi:10.1172/JCI9259. PMC 300837. PMID 10772649.
^ Laugerette F, Passilly-Degrace P, Patris B, Niot I, Febbraio M, Montmayeur JP, Besnard P (November 2005). "CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions". The Journal of Clinical Investigation. 115 (11): 3177–84. doi:10.1172/JCI25299. PMC 1265871. PMID 16276419.
^ Pepino MY, Love-Gregory L, Klein S, Abumrad NA (March 2012). "The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects". Journal of Lipid Research. 53 (3): 561–6. doi:10.1194/jlr.M021873. PMC 3276480. PMID 22210925.
^ DiPatrizio NV (September 2014). "Is fat taste ready for primetime?". Physiology & Behavior. 136: 145–54. doi:10.1016/j.physbeh.2014.03.002. PMC 4162865. PMID 24631296.
^ Drover VA, Ajmal M, Nassir F, Davidson NO, Nauli AM, Sahoo D, et al. (May 2005). "CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood". The Journal of Clinical Investigation. 115 (5): 1290–7. doi:10.1172/JCI21514. PMC 1074677. PMID 15841205.
^ Rać ME, Safranow K, Poncyljusz W (2007). "Molecular basis of human CD36 gene mutations". Molecular Medicine. 13 (5–6): 288–96. doi:10.2119/2006-00088.Rac. PMC 1936231. PMID 17673938.
^ Ana-Maria Enciu, Eugen Radu, Ionela Daniela Popescu, Mihail Eugen Hinescu, Laura Cristina Ceafalan (2018). "Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?". BioMed Research International. 2018: 1–12. doi:10.1155/2018/7801202. PMC 6057354. PMID 30069479.
^ Jingchun Wang, Yongsheng Li (2019). "CD36 tango in cancer: signaling pathways and functions". Theranostics. 9 (17): 4893–490. doi:10.7150/thno.36037. PMC 6691380. PMID 31410189.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135218 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002944 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2468670-5] Tandon NN, Kralisz U, Jamieson GA (May 1989). "Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion". The Journal of Biological Chemistry. 264 (13): 7576–83. doi:10.1016/S0021-9258(18)83273-2. PMID 2468670.

[pmid1379600-6] Silverstein RL, Baird M, Lo SK, Yesner LM (August 1992). "Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor". The Journal of Biological Chemistry. 267 (23): 16607–12. doi:10.1016/S0021-9258(18)42046-7. PMID 1379600.

[pmid2473841-7] Oquendo P, Hundt E, Lawler J, Seed B (July 1989). "CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes". Cell. 58 (1): 95–101. doi:10.1016/0092-8674(89)90406-6. PMID 2473841. S2CID 22059108.

[pmid7685021-8] Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA (June 1993). "CD36 is a receptor for oxidized low density lipoprotein". The Journal of Biological Chemistry. 268 (16): 11811–6. doi:10.1016/S0021-9258(19)50272-1. PMID 7685021.

[pmid7538425-9] Nicholson AC, Frieda S, Pearce A, Silverstein RL (February 1995). "Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site". Arteriosclerosis, Thrombosis, and Vascular Biology. 15 (2): 269–75. doi:10.1161/01.ATV.15.2.269. PMID 7538425.

[pmid9555943-10] Calvo D, Gómez-Coronado D, Suárez Y, Lasunción MA, Vega MA (April 1998). "Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL". Journal of Lipid Research. 39 (4): 777–88. doi:10.1016/S0022-2275(20)32566-9. PMID 9555943.^{[permanent dead link]}

[pmid12105195-11] Podrez EA, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, et al. (October 2002). "Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36". The Journal of Biological Chemistry. 277 (41): 38503–16. doi:10.1074/jbc.M203318200. PMID 12105195.

[pmid8694909-12] Baillie AG, Coburn CT, Abumrad NA (September 1996). "Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homolog". The Journal of Membrane Biology. 153 (1): 75–81. doi:10.1007/s002329900111. PMID 8694909. S2CID 5911289.

[pmid12021254-13] Hajri T, Han XX, Bonen A, Abumrad NA (May 2002). "Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice". The Journal of Clinical Investigation. 109 (10): 1381–9. doi:10.1172/JCI14596. PMC 150975. PMID 12021254.

[pmid14640889-14] Pravenec M, Landa V, Zídek V, Musilová A, Kazdová L, Qi N, et al. (2003). "Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension" (PDF). Physiological Research. 52 (6): 681–8. doi:10.33549/physiolres.930380. PMID 14640889.

[pmid34880245-15] Mistry JJ, Bowles KM, Rushworth SA (December 2021). "Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection". Nature Communications. 12 (1): 7130. Bibcode:2021NatCo..12.7130M. doi:10.1038/s41467-021-27460-9. PMC 8655073. PMID 34880245.

[pmid10772649-16] Febbraio M, Podrez EA, Smith JD, Hajjar DP, Hazen SL, Hoff HF, et al. (April 2000). "Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice". The Journal of Clinical Investigation. 105 (8): 1049–56. doi:10.1172/JCI9259. PMC 300837. PMID 10772649.

[pmid16276419-17] Laugerette F, Passilly-Degrace P, Patris B, Niot I, Febbraio M, Montmayeur JP, Besnard P (November 2005). "CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions". The Journal of Clinical Investigation. 115 (11): 3177–84. doi:10.1172/JCI25299. PMC 1265871. PMID 16276419.

[Pepino_2012-18] Pepino MY, Love-Gregory L, Klein S, Abumrad NA (March 2012). "The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects". Journal of Lipid Research. 53 (3): 561–6. doi:10.1194/jlr.M021873. PMC 3276480. PMID 22210925.

[pmid24631296-19] DiPatrizio NV (September 2014). "Is fat taste ready for primetime?". Physiology & Behavior. 136: 145–54. doi:10.1016/j.physbeh.2014.03.002. PMC 4162865. PMID 24631296.

[pmid15841205-20] Drover VA, Ajmal M, Nassir F, Davidson NO, Nauli AM, Sahoo D, et al. (May 2005). "CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood". The Journal of Clinical Investigation. 115 (5): 1290–7. doi:10.1172/JCI21514. PMC 1074677. PMID 15841205.

[pmid17673938-21] Rać ME, Safranow K, Poncyljusz W (2007). "Molecular basis of human CD36 gene mutations". Molecular Medicine. 13 (5–6): 288–96. doi:10.2119/2006-00088.Rac. PMC 1936231. PMID 17673938.

[pmid30069479-22] Ana-Maria Enciu, Eugen Radu, Ionela Daniela Popescu, Mihail Eugen Hinescu, Laura Cristina Ceafalan (2018). "Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?". BioMed Research International. 2018: 1–12. doi:10.1155/2018/7801202. PMC 6057354. PMID 30069479.

[pmid31410189-23] Jingchun Wang, Yongsheng Li (2019). "CD36 tango in cancer: signaling pathways and functions". Theranostics. 9 (17): 4893–490. doi:10.7150/thno.36037. PMC 6691380. PMID 31410189.

CD36 information

and 23 Related for: CD36 information

CD36

Taste receptor

CD36 antigen

Taste

Thrombospondin

Phagocytosis

Randle cycle

Integral membrane protein

Asim Duttaroy

Kell antigen system

Foam cell

Vitamin K

Cluster of differentiation

Transforming growth factor beta

CD20

Thrombospondin 1

CD28

Programmed cell death protein 1

Calprotectin

Niacin

CD19

Interleukin 10

Carcinoembryonic antigen