positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
regulation of actin cytoskeleton organization
response to retinoic acid
phosphorylation
response to hyperoxia
retina vasculature development in camera-type eye
metanephric glomerulus morphogenesis
metanephric mesenchymal cell migration
wound healing
cellular response to platelet-derived growth factor stimulus
negative regulation of apoptotic process
response to fluid shear stress
response to estrogen
chemotaxis
metanephric mesenchyme development
response to hydrogen peroxide
positive regulation of smooth muscle cell proliferation
response to estradiol
intracellular signal transduction
response to organic cyclic compound
smooth muscle cell chemotaxis
positive regulation of cell migration
aorta morphogenesis
MAPK cascade
positive regulation of phosphatidylinositol 3-kinase activity
metanephric glomerular capillary formation
multicellular organism development
positive regulation of calcium ion import
glycosaminoglycan biosynthetic process
positive regulation of cell population proliferation
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cell migration
signal transduction
positive regulation of Rho protein signal transduction
G protein-coupled receptor signaling pathway
phosphatidylinositol phosphate biosynthetic process
positive regulation of hepatic stellate cell activation
positive regulation of fibroblast proliferation
positive regulation of apoptotic process
human ageing
male gonad development
lung growth
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of protein kinase B signaling
hematopoietic progenitor cell differentiation
positive regulation of MAPK cascade
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5159
18596
Ensembl
ENSG00000113721
ENSMUSG00000024620
UniProt
P09619
P05622
RefSeq (mRNA)
NM_002609 NM_001355016 NM_001355017
NM_001146268 NM_008809
RefSeq (protein)
NP_002600 NP_001341945 NP_001341946
NP_001139740 NP_032835
Location (UCSC)
Chr 5: 150.11 – 150.16 Mb
Chr 18: 61.18 – 61.22 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.
^ abcGRCh38: Ensembl release 89: ENSG00000113721 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024620 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies. The PDGFRB gene is located...
rearrangements in PDGFRA, PDGFRB, or FGFR1. CEL not otherwise specified (CEL NOS) is a form in which BCR-ABL1 fusion genes and PDGFRA, PDGFRB, and FGFR1 rearrangements...
mutations in either the PDGFRB or NOTCH3 gene. However, most IMF cases have no family history of the disease but nonetheless have PDGFRB gene mutations in their...
lymphoid neoplasms associated with eosinophilia and abnormalities of PDGFRA, PDGFRB, FGFR1, and, tentatively, PCMA-JAK2. Informally, these diseases are also...
must be >1x109/L, no Philadelphia chromosome or mutations in the PDGFRA or PDGFRB gene should be present, the blast count must be <20% and dysplasia of at...
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 (i.e. high eosinophil blood counts caused by mutations in the...
released from endothelial cells in brain vasculature and binds to the receptor PDGFRB on pericytes, initiating their proliferation and investment in the vasculature...
chromosomal translocation in which the COL1A1 gene becomes fused to the PDGFRB gene. This results in over-active PDGF signaling, which is thought to promote...
this condition: PDGFB on chromosome 22 and PDGFRB on chromosome 5. These genes are biochemically linked: PDGFRB encodes the platelet-derived growth factor...
Kosaki overgrowth syndrome is a rare syndrome caused by mutations in the PDGFRB gene. The features of this syndrome affect the face, skin, brain and the...
receptor tyrosine kinase is a negative prognostic factor. Expression of PDGFRB is a positive prognostic factor. In general, mesothelioma is characterized...
2015). "Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1". American Journal of Clinical Pathology. 144 (3): 377–92. doi:10...
Nilotinib inhibits the kinases BCR-ABL, KIT, LCK, EPHA3, EPHA8, DDR1, DDR2, PDGFRB, MAPK11 and ZAK. Structurally related to imatinib, It is 10–30 fold more...
been discovered: Cancer cells begin to overexpress cell surface protein PDGFRB, creating an alternative survival pathway. A second oncogene called NRAS...
(2015). "Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1". American Journal of Clinical Pathology. 144 (3): 377–92. doi:10...
known as Platelet-derived growth factor receptor, beta (PDGFRB); a protein in humans encoded by PDGFRB gene. A cell surface tyrosine kinase receptor for members...
Global Information
