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PDGFRB information


PDGFRB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDGFRB, CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1, KOGS, PENTT, platelet derived growth factor receptor beta
External IDsOMIM: 173410; MGI: 97531; HomoloGene: 1960; GeneCards: PDGFRB; OMA:PDGFRB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002609
NM_001355016
NM_001355017

NM_001146268
NM_008809

RefSeq (protein)

NP_002600
NP_001341945
NP_001341946

NP_001139740
NP_032835

Location (UCSC)Chr 5: 150.11 – 150.16 MbChr 18: 61.18 – 61.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113721 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024620 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

and 26 Related for: PDGFRB information

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PDGFRB

Last Update:

encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies. The PDGFRB gene is located...

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Infantile myofibromatosis

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mutations in either the PDGFRB or NOTCH3 gene. However, most IMF cases have no family history of the disease but nonetheless have PDGFRB gene mutations in their...

Word Count : 3744

Chronic eosinophilic leukemia

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rearrangements in PDGFRA, PDGFRB, or FGFR1. CEL not otherwise specified (CEL NOS) is a form in which BCR-ABL1 fusion genes and PDGFRA, PDGFRB, and FGFR1 rearrangements...

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Clonal hypereosinophilia

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lymphoid neoplasms associated with eosinophilia and abnormalities of PDGFRA, PDGFRB, FGFR1, and, tentatively, PCMA-JAK2. Informally, these diseases are also...

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Eosinophilia

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Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 (i.e. high eosinophil blood counts caused by mutations in the...

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Chronic myelomonocytic leukemia

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must be >1x109/L, no Philadelphia chromosome or mutations in the PDGFRA or PDGFRB gene should be present, the blast count must be <20% and dysplasia of at...

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Pericyte

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released from endothelial cells in brain vasculature and binds to the receptor PDGFRB on pericytes, initiating their proliferation and investment in the vasculature...

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Tumors of the hematopoietic and lymphoid tissues

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Myeloid/lymphoid neoplasms with PDGFRA rearrangement Myeloid/lymphoid neoplasms with PDGFRB rearrangement Myeloid/lymphoid neoplasms with FGFR1 rearrangement Myeloid/lymphoid...

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Kosaki overgrowth syndrome

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Kosaki overgrowth syndrome is a rare syndrome caused by mutations in the PDGFRB gene. The features of this syndrome affect the face, skin, brain and the...

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Sarcoma

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chromosomal translocation in which the COL1A1 gene becomes fused to the PDGFRB gene. This results in over-active PDGF signaling, which is thought to promote...

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Primary familial brain calcification

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this condition: PDGFB on chromosome 22 and PDGFRB on chromosome 5. These genes are biochemically linked: PDGFRB encodes the platelet-derived growth factor...

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Tyrosine kinase

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MATK; MERTK; MET; MLTK; MST1R; MUSK; NPR1; NTRK1; NTRK2; NTRK3; PDGFRA; PDGFRB; PKDCC; PLK4; PTK2; PTK2B; PTK6; PTK7; RET; ROR1; ROR2; ROS1; RYK; SRC;...

Word Count : 5251

Mesothelioma

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receptor tyrosine kinase is a negative prognostic factor. Expression of PDGFRB is a positive prognostic factor. In general, mesothelioma is characterized...

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Tryptase

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2015). "Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1". American Journal of Clinical Pathology. 144 (3): 377–92. doi:10...

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Vemurafenib

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been discovered: Cancer cells begin to overexpress cell surface protein PDGFRB, creating an alternative survival pathway. A second oncogene called NRAS...

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List of genetic disorders

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syndrome 9q34 D Kniest dysplasia COL2A1 1:1,000,000 Kosaki overgrowth syndrome PDGFRB Krabbe disease GALC 1:100,000 Kufor–Rakeb syndrome ATP13A2 LCAT deficiency...

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List of distinct cell types in the adult human body

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system None None unknown None COL1A2, DCN, LAMC3, HIGD1B, COX4I2, TRPC6, PDGFRB lymph node lymphatic vessel endothelial cell unknown unknown prostate gland...

Word Count : 1209

Janus kinase

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family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB) FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1...

Word Count : 974

Nilotinib

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Nilotinib inhibits the kinases BCR-ABL, KIT, LCK, EPHA3, EPHA8, DDR1, DDR2, PDGFRB, MAPK11 and ZAK. Structurally related to imatinib, It is 10–30 fold more...

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Immunoglobulin domain

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NFASC NOPE NPHS1 NPTN NRCAM NRG1 NT NTRK3 OBSCN OBSL1 OPCML PAPLN PDGFRA PDGFRB PDGFRL PECAM1 PRODH2 PSG1 PSG10 PSG11 PSG11s' PSG2 PSG3 PSG4 PSG5 PSG6 PSG7...

Word Count : 493

Myeloid sarcoma

Last Update:

(2015). "Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1". American Journal of Clinical Pathology. 144 (3): 377–92. doi:10...

Word Count : 1927

HER2

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family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB) FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1...

Word Count : 4735

Epidermal growth factor receptor

Last Update:

family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB) FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1...

Word Count : 6879

List of human clusters of differentiation

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known as Platelet-derived growth factor receptor, beta (PDGFRB); a protein in humans encoded by PDGFRB gene. A cell surface tyrosine kinase receptor for members...

Word Count : 467

Protein kinase inhibitor

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molecule 2013 Non-small cell lung cancer Axitinib VEGFR1/VEGFR2/VEGFR3/PDGFRB/c-KIT Pfizer Small molecule 2012 Renal cell carcinoma Bosutinib Bcr-Abl...

Word Count : 742

Receptor tyrosine kinase

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family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB) FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1...

Word Count : 3078

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