Platelet transfusion, also known as platelet concentrate, is used to prevent or treat bleeding in people with either a low platelet count or poor platelet function.[1] Often this occurs in people receiving cancer chemotherapy.[1] Preventive transfusion is often done in those with platelet levels of less than 10 x 109/L.[2] In those who are bleeding transfusion is usually carried out at less than 50 x 109/L.[2] Blood group matching (ABO, RhD) is typically recommended before platelets are given.[2] Unmatched platelets, however, are often used due to the unavailability of matched platelets.[3] They are given by injection into a vein.[4]
Side effects can include allergic reactions such as anaphylaxis, infection, and lung injury.[2] Bacterial infections are relatively more common with platelets as they are stored at warmer temperatures.[2] Platelets can be produced either from whole blood or by apheresis.[1] They keep for up to five to seven days.[1]
Platelet transfusions came into medical use in the 1950s and 1960s.[1][5] It is on the World Health Organization's List of Essential Medicines.[6][7] Some versions of platelets have had the white blood cells partially removed or been gamma irradiated which have specific benefits for certain populations.[8]
^ abcdeFisk JM, Pisciotto PT, Snyder EL, Perrota PL (2007). "Platelets and related products". In Hillyer CD, Silberstein LE, Ness PM, Anderson KC, Roback JD (eds.). Blood Banking and Transfusion Medicine: Basic Principles & Practice. Elsevier Health Sciences. pp. 308–310. ISBN 978-0443069819. Archived from the original on 2017-01-12.
^Josephson CD, Castillejo MI, Grima K, Hillyer CD (February 2010). "ABO-mismatched platelet transfusions: strategies to mitigate patient exposure to naturally occurring hemolytic antibodies". Transfusion and Apheresis Science. 42 (1): 83–88. doi:10.1016/j.transci.2009.10.013. PMID 20034854.
^Flagg C (2015). "Intravenous Therapy". In Linton AD (ed.). Introduction to Medical-Surgical Nursing. Elsevier Health Sciences. p. 287. ISBN 978-1455776412. Archived from the original on 2017-01-12.
^Das PC, Smit-Sibinga CT, Halie MR (2012). Supportive therapy in haematology. Springer Science & Business Media. p. 190. ISBN 978-1461325772. Archived from the original on 2017-01-10.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^Hillyer CD, Silberstein LE, Ness PM, Anderson KC, Roback JD, eds. (2007). Blood Banking and Transfusion clinical Basic Principles & Practice. Elsevier Health Sciences. p. 320. ISBN 978-0443069819. Archived from the original on 2017-01-12.
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Platelettransfusion, also known as platelet concentrate, is used to prevent or treat bleeding in people with either a low platelet count or poor platelet...
after transfusion is termed the "increment" and is calculated by subtracting the pre-transfusionplatelet count from the post-transfusionplatelet count...
Platelettransfusion refractoriness is the repeated failure to achieve the desired level of blood platelets in a patient following a platelet transfusion...
involves antibodies that destroy platelets, therefore any newly transfusedplatelets will also be destroyed. Platelettransfusion may be used in emergency bleeding...
characterized by abnormally low levels of platelets (also known as thrombocytes) in the blood. Low levels of platelets in turn may lead to prolonged or excessive...
Blood transfusion is the process of transferring blood products into a person's circulation intravenously. Transfusions are used for various medical conditions...
remedies. Platelettransfusion alone is normally not recommended except in an emergency and is usually unsuccessful in producing a long-term platelet count...
further categorize this disorder which each need differing treatments. Platelettransfusion is the main treatment for people presenting with bleeding symptoms...
hemolytic transfusion reaction (AHTR), also called immediate hemolytic transfusion reaction, is a life-threatening reaction to receiving a blood transfusion. AHTRs...
vein Platelettransfusion, the infusion of platelets into an individual's blood Transfusion (journal), a research journal on blood transfusion and related...
babies in which the platelet count is decreased because the mother's immune system attacks her fetus' or newborn's platelets. A low platelet count increases...
are hospitalized. The results may indicate a need for a blood or platelettransfusion. The complete blood count has specific applications in many medical...
stored at 2.0 °C-6.0 °C for 35–45 days. Platelettransfusion is transfused to those with low platelet count. Platelets can be stored at room temperature for...
(ed.). "Comparison of different platelet count thresholds to guide administration of prophylactic platelettransfusion for preventing bleeding in people...
2015). "Comparison of different platelet count thresholds to guide administration of prophylactic platelettransfusion for preventing bleeding in people...
Transfusion medicine (or transfusiology) is the branch of medicine that encompasses all aspects of the transfusion of blood and blood components including...
is not commonly used in transfusion medicine. Blood components include: red blood cell concentrates or suspensions; platelets produced from whole blood...
Deficiencies of platelet function may require platelettransfusion while deficiencies of clotting factors may require transfusion of either fresh frozen...
recipients of transfusedplatelets from donors with different HPAs. These antibodies cause neonatal alloimmune thrombocytopenia, post-transfusion purpura,...
An allergic transfusion reaction is when a blood transfusion results in allergic reaction. It is among the most common transfusion reactions to occur....
is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes), which are necessary for normal clotting. In humans, megakaryocytes...
Immunosuppressants, such as glucocorticoids, and rituximab may also be used. Platelettransfusions are generally not recommended. About 1 per 100,000 people are affected...
(March 2021). "Platelet Indices and Their Kinetics Predict Mortality in Patients of Sepsis". Indian Journal of Hematology & Blood Transfusion. 37 (4): 600–608...
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