Plasmacytoid dendritic cells (pDCs) are a rare type of immune cell that are known to secrete large quantities of type 1 interferon (IFNs) in response to a viral infection.[1] They circulate in the blood and are found in peripheral lymphoid organs. They develop from bone marrow hematopoietic stem cells and constitute < 0.4% of peripheral blood mononuclear cells (PBMC).[1][2] Other than conducting antiviral mechanisms, pDCs are considered to be key in linking the innate and adaptive immune systems. However, pDCs are also responsible for participating in and exacerbating certain autoimmune diseases like lupus.[3] pDCs that undergo malignant transformation cause a rare hematologic disorder, blastic plasmacytoid dendritic cell neoplasm.[4]
^ abLaustsen, Anders; van der Sluis, Renée M.; Gris-Oliver, Albert; Hernández, Sabina Sánchez; Cemalovic, Ena; Tang, Hai Q.; Pedersen, Lars Henning; Uldbjerg, Niels; Jakobsen, Martin R.; Bak, Rasmus O. (2021-09-02). "Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells". eLife. 10: e65528. doi:10.7554/eLife.65528. ISSN 2050-084X. PMC 8445615. PMID 34473049.
^Tversky JR, Le TV, Bieneman AP, Chichester KL, Hamilton RG, Schroeder JT (May 2008). "Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-alpha via Toll-like receptor 9". Clin. Exp. Allergy. 38 (5): 781–8. doi:10.1111/j.1365-2222.2008.02954.x. PMC 2707903. PMID 18318750.
^Liu, Yong-Jun (April 2005). "IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors". Annual Review of Immunology. 23 (1): 275–306. doi:10.1146/annurev.immunol.23.021704.115633. PMID 15771572.
^Owczarczyk-Saczonek A, Sokołowska-Wojdyło M, Olszewska B, Malek M, Znajewska-Pander A, Kowalczyk A, Biernat W, Poniatowska-Broniek G, Knopińska-Posłuszny W, Kozielec Z, Nowicki R, Placek W (April 2018). "Clinicopathologic retrospective analysis of blastic plasmacytoid dendritic cell neoplasms". Postepy Dermatologii I Alergologii. 35 (2): 128–138. doi:10.5114/ada.2017.72269. PMC 5949541. PMID 29760611.
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cell volume. The most common division of dendriticcells is conventional dendriticcells (a.k.a. myeloid dendriticcells) vs. plasmacytoiddendritic cell...
Plasmacytoiddendriticcells (pDCs) are a rare type of immune cell that are known to secrete large quantities of type 1 interferon (IFNs) in response to...
Blastic plasmacytoiddendriticcell neoplasm (BPDCN) is a rare hematologic malignancy. It was initially regarded as a form of lymphocyte-derived cutaneous...
tissues. Blastic plasmacytoiddendriticcell neoplasm: A rare hematologic malignancy which is a malignancy of plasmacytoiddendriticcells. Hematological...
Elzonris, is an anti-cancer medication for the treatment of blastic plasmacytoiddendriticcell neoplasm (BPDCN). Tagraxofusp is a fusion protein consisting...
nucleated cells when they recognize that a virus has invaded them. The most prolific producers of IFN-α and IFN-β are plasmacytoiddendriticcells circulating...
exposure plasmacytoiddendriticcells from the liver and mesenteric lymph node can induce anergy or deletion of antigen specific T cells. Anergic T cells are...
itself. The link between atherosclerosis and autoimmunity is plasmacytoiddendriticcells (pDCs). PDCs contribute to the early stages of the formation...
Retrieved 2023-12-30. Voskanyan, Astghik; et al. (2023). "Blastic PlasmacytoidDendriticCell Neoplasm (BPDCN):Multi-Center Collaboration and Global Registry...
constitutively expressed in mature B cells, plasma cells and plasmacytoiddendriticcells, and in many other cells, it is only expressed as a response...
CLEC4C is a membrane protein of plasmacytoiddendriticcells used as a marker for this kind of cells and denoted as CD303 in the nomenclature of the Cluster...
Receptor 9 (TLR9), which is constitutively expressed only in B cells and plasmacytoiddendriticcells (pDCs) in humans and other higher primates. Since 1893,...
gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoiddendriticcells (PDCs). This gene is highly expressed...
2019). "Cutting Edge: Dysregulated Endocannabinoid-Rheostat for PlasmacytoidDendriticCell Activation in a Systemic Lupus Endophenotype". Journal of Immunology...
therapeutics are. In 2017, UCART123 was in phase 1 trials for blastic plasmacytoiddendriticcell neoplasm (BPDCN) and acute myeloid leukaemia (AML). In early...
human plasmacytoiddendriticcells. Sendai virus can induce the production of many cytokines that enhance cellular immune responses against cancer cells. SeV...
NK cells to elicit an anti-viral response, involving IRF3/IRF7 antiviral pathways, and are also active against tumors. Plasmacytoiddendriticcells have...
partially contribute to generation of other cell types, present in the thymus, mainly plasmacytoiddendriticcells (pDCs). But this has not yet been clearly...
accumulate. Different dendriticcells sub types, such as Langerhans cells, inflammatory dendritic epidermal cells and plasmacytoiddendriticcells have a role to...
Panoutsakopoulou; An integrin axis induces IFN-β production in plasmacytoiddendriticcells. J Cell Biol 5 September 2022; 221 (9): e202102055. doi: https://doi...
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