Elimination of autoreactive lymphocytes by the immune system
In immunology, central tolerance (also known as negative selection) is the process of eliminating any developing T or B lymphocytes that are autoreactive, i.e. reactive to the body itself.[1] Through elimination of autoreactive lymphocytes, tolerance ensures that the immune system does not attack self peptides.[2] Lymphocyte maturation (and central tolerance) occurs in primary lymphoid organs such as the bone marrow and the thymus. In mammals, B cells mature in the bone marrow and T cells mature in the thymus.[1]
Central tolerance is not perfect, so peripheral tolerance exists as a secondary mechanism to ensure that T and B cells are not self-reactive once they leave primary lymphoid organs.[3][page needed] Peripheral tolerance is distinct from central tolerance in that it occurs once developing immune cells exit primary lymphoid organs (the thymus and bone-marrow), prior to their export into the periphery.[1]
^ abcOwen JA, Punt J, Stranford SA, Jones PP, Kuby J (2013). Kuby immunology (7th ed.). New York: W.H. Freeman. ISBN 978-1-4292-1919-8. OCLC 820117219.
^Romagnani S (2006). "Immunological tolerance and autoimmunity". Internal and Emergency Medicine. 1 (3): 187–196. doi:10.1007/bf02934736. PMID 17120464. S2CID 27585046.
^Janeway Jr CA, Travers P, Walport M, Shlomchik MJ (2001). Immunobiology 5: The Immune System in Health and Disease (5th ed.). New York: Garland. ISBN 978-0-8153-3642-6. OCLC 45708106.
In immunology, centraltolerance (also known as negative selection) is the process of eliminating any developing T or B lymphocytes that are autoreactive...
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of negative selection. Ultimately, clonal deletion plays a role in centraltolerance. Clonal deletion can help protect individuals against autoimmunity...
HLA-B*38, and HLA-B*39. Other genes relating to the immune system and centraltolerance may also be involved, such as interleukin receptor genes. Thematically...
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regulator, to eliminate T cells with self-reactive TCRs via processes of centraltolerance e.g. negative selection and protect the body against development of...
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D (October 2006). "Receptor editing in lymphocyte development and centraltolerance". Nature Reviews. Immunology. 6 (10): 728–40. doi:10.1038/nri1939...
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recent thymic emigrants. This process is an important component of centraltolerance and serves to prevent the formation of self-reactive T cells that...
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