Foam cells (one indicated by arrows) visible in the finger-like projections into the gallbladder lumen in a case of cholesterolosis
Details
Precursor
monocyte-derived macrophage
Identifiers
MeSH
D005487
FMA
83586
Anatomical terms of microanatomy
[edit on Wikidata]
Foam cells, also called lipid-laden macrophages, are a type of cell that contain cholesterol. These can form a plaque that can lead to atherosclerosis and trigger myocardial infarction and stroke.[1][2][3]
Foam cells are fat-laden cells with a M2 macrophage-like phenotype. They contain low density lipoproteins (LDL) and can only be truly detected by examining a fatty plaque under a microscope after it is removed from the body.[4] They are named because the lipoproteins give the cell a foamy appearance.[5]
Despite the connection with cardiovascular diseases they might not be inherently dangerous.[6]
Some foam cells are derived from smooth muscle cells and present a limited macrophage-like phenotype.[7][8][9]
^Yu XH, Fu YC, Zhang DW, Yin K, Tang CK (September 2013). "Foam cells in atherosclerosis". Clinica Chimica Acta. 424: 245–52. doi:10.1016/j.cca.2013.06.006. PMID 23782937.
^Oh J, Riek AE, Weng S, Petty M, Kim D, Colonna M, Cella M, Bernal-Mizrachi C (April 2012). "Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation". The Journal of Biological Chemistry. 287 (15): 11629–41. doi:10.1074/jbc.M111.338673. PMC 3320912. PMID 22356914.
^Cite error: The named reference pmid21076992 was invoked but never defined (see the help page).
^"Foam cells - Latest research and news | Nature".
^Cite error: The named reference :4 was invoked but never defined (see the help page).
^Li, Yi; Zhu, Huan; Zhang, Qianyu; Han, Ximeng; Zhang, Zhenqian; Shen, Linghong; Wang, Lixin; Lui, Kathy O.; He, Ben; Zhou, Bin (2021-11-23). "Smooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque". Cell Discovery. 7 (1): 111. doi:10.1038/s41421-021-00328-4. ISSN 2056-5968. PMC 8608914. PMID 34811358.
^Gui, Yuzhou; Zheng, Hongchao; Cao, Richard Y. (2022). "Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms". Frontiers in Cardiovascular Medicine. 9: 845942. doi:10.3389/fcvm.2022.845942. ISSN 2297-055X. PMC 9043520. PMID 35498045.
^Pryma, Collin S.; Ortega, Carleena; Dubland, Joshua A.; Francis, Gordon A. (April 2019). "Pathways of smooth muscle foam cell formation in atherosclerosis". Current Opinion in Lipidology. 30 (2): 117–124. doi:10.1097/MOL.0000000000000574. ISSN 0957-9672. PMID 30664015. S2CID 58633787.
Foamcells, also called lipid-laden macrophages, are a type of cell that contain cholesterol. These can form a plaque that can lead to atherosclerosis...
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referred to as "viscoelastic" polyurethane foam, or low-resilience polyurethane foam (LRPu). The foam bubbles or ‘cells’ are open, effectively creating a matrix...
polyurethane foam comes in a range of densities and cell structure. Low density foams are referred to as open cell SPF while higher density foams are referred...
of the cell. If no more than one of the walls of the cell are holes, the foam is considered closed-celled in nature. For most synthetic foams, a mixture...
carries it back to the liver. The foamcells and platelets encourage the migration and proliferation of smooth muscle cells, which in turn ingest lipids,...
membranes (with associated high cholesterol content) they are called foamcells. When foamcells die, their contents are released, which attracts more macrophages...
and taken up by macrophages, which become engorged and form foamcells. These foamcells often become trapped in the walls of blood vessels and contribute...
open-cellfoam, closed-cellfoam rarely requires any trimming, with little or no waste. Open cellfoams will allow timber to breathe. Open cellfoams are...
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Acoustic foam is an open celledfoam used for acoustic treatment. It attenuates airbone sound waves, reducing their amplitude, for the purposes of noise...
all foamed polystyrene products, although strictly it should only be used for "extruded closed-cell" polystyrene foams made by Dow Chemicals. Foams are...
more padding on striking surfaces. Some foam weapons also feature a tip made of open cellfoam or other foam types that allow a progressive give, which...
periphery of the cell is pale and foamy in appearance. Touton giant cells are formed by the fusion of macrophage-derived foamcells. It has been suggested...
better known as "foamcells". Foamcells characterize atherosclerotic lesions. In addition to this possible mechanism of foamcell generation, an increase...
Foam latex or latex foam rubber is a lightweight form of latex containing bubbles known as cells, created from liquid latex. The foam is generally created...
Synthetic absorption materials are porous, referring to open cellfoam (acoustic foam, soundproof foam). Fibrous absorption material such as cellulose, mineral...
affects small arteries and arterioles, which carry nutrients and blood to the cells. Atherosclerosis is the narrowing of arteries from a buildup of plaque,...
important for the development of senile hemangioma, induced cell proliferation of the endothelial cells. They also found that targeting MEK1 and cyclin E1 with...
hardens and eventually shrinks away. Recent evidence with foam sclerotherapy shows that the foam containing the irritating sclerosant quickly appears in...
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