Plasma gelsolin (pGSN) is an 83 kDa abundant protein constituent of normal plasma and an important component of the innate immune system. The identification of pGSN in Drosophila melanogaster[1] and C. elegans[2] points to an ancient origin early in evolution.[3] Its extraordinary structural conservation reflects its critical regulatory role in multiple essential functions.[4] Its roles include the breakdown of filamentous actin released from dead cells, activation of macrophages, and localization of the inflammatory response. Substantial decreases in plasma levels are observed in acute and chronic infection and injury in both animal models and in humans. Supplementation therapies with recombinant human pGSN have been shown effective in more than 20 animal models.
pGSN has a cytoplasmic isoform (cGSN) known to be an actin-binding protein controlling cytoskeletal dynamics. cGSN is expressed from the same gene, and is identical to pGSN except for its lack of a 24 amino acid N-terminal extension.
^Shi, Yigong (2004-08-01). "Caspase activation, inhibition, and reactivation: A mechanistic view". Protein Science. 13 (8): 1979–1987. doi:10.1110/ps.04789804. ISSN 0961-8368. PMC 2279816. PMID 15273300.
^Klaavuniemi, Tuula; Yamashiro, Sawako; Ono, Shoichiro (2008-09-19). "Caenorhabditis elegans Gelsolin-like Protein 1 Is a Novel Actin Filament-severing Protein with Four Gelsolin-like Repeats". Journal of Biological Chemistry. 283 (38): 26071–26080. doi:10.1074/jbc.M803618200. ISSN 0021-9258. PMC 2533794. PMID 18640981.
^Archer, Stuart K.; Claudianos, Charles; Campbell, Hugh D. (2005). "Evolution of the gelsolin family of actin-binding proteins as novel transcriptional coactivators". BioEssays. 27 (4): 388–396. doi:10.1002/bies.20200. ISSN 1521-1878. PMID 15770676. S2CID 40585071.
^Cite error: The named reference Lee1992 was invoked but never defined (see the help page).
Plasmagelsolin (pGSN) is an 83 kDa abundant protein constituent of normal plasma and an important component of the innate immune system. The identification...
closely related secreted form, Plasmagelsolin, that contains an additional 24 AA N-terminal extension. Plasmagelsolin's ability to sever actin filaments...
the SCIN gene. Scinderin is an actin severing protein belonging to the gelsolin superfamily. It was discovered in Dr. Trifaro's laboratory at the University...
where it prompts the release of cytochrome c leading to cell death. Actin, gelsolin and p21-activated kinase 2 PAK2 are three other proteins that are myristoylated...
numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin...
annexin repeat. Several proteins consist of annexin with other domains like gelsolin. The basic structure of an annexin is composed of two major domains. The...
phosphatidylinositol 4,5-bisphosphate (PIP2), a phospholipid that is located in the plasma membrane, by phospholipase C (PLC). Together with diacylglycerol (DAG),...
biomarker that can be measured with immunoassays in cerebrospinal fluid and plasma and reflects axonal damage in a wide variety of neurological disorders....
marker in the laboratory diagnosis of heart attack. It occurs in different plasma concentration but the same circumstances as troponin T - either test can...
regions, affecting the organ's ability to filter and excrete waste and retain plasma protein. This can lead to high levels of protein in the urine (proteinuria)...
ions from intracellular stores, and/or when Ca2+ enters the cell through plasma membrane ion channels. Under certain conditions, the intracellular Ca2+...
although the significance is unclear. TNIK has been shown to phosphorylate Gelsolin, a protein involved in F-actin depolymerisation thus inducing cytoskeletal...
such as Capping Protein and CapG, etc. Filament-severing proteins like gelsolin. Actin depolymerizing proteins such as ADF/cofilin. The actin filament...
000 Dalton and are preferentially located on the cytosolic face of the plasma membrane. Annexin A1 protein has an apparent relative molecular mass of...
transglutaminase which eventually form a cornified cell envelope beneath the plasma membrane terminal differentiation loss of nuclei and organelles, in the...
support proteins that reside on the inside surface of each muscle fiber's plasma membrane (sarcolemma). These support proteins on the inside surface of the...
FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein. Fibulin-1 is a secreted glycoprotein that is found in association with...
locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes, but it is always found intracellularly. Many of...
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