SCIN information

SCIN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FG6, 5A1K, 5A1M
Identifiers
Aliases	SCIN, scinderin
External IDs	OMIM: 613416 MGI: 1306794 HomoloGene: 36296 GeneCards: SCIN
Gene location (Human)
Chr.	Chromosome 7 (human)
End	12,660,182 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	40,184,227 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; tibia; ; renal medulla; ; duodenum; ; Achilles tendon; ; kidney; ; palpebral conjunctiva; ; oral cavity; ; right uterine tube; ; rectum;
	Top expressed in
	left colon; ; molar; ; corneal stroma; ; Paneth cell; ; seminal vesicula; ; jejunum; ; medullary collecting duct; ; conjunctival fornix; ; kidney; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; phosphatidylserine binding; actin filament binding; 1-phosphatidylinositol binding; actin binding; phosphatidylinositol-4,5-bisphosphate binding; metal ion binding;
Cellular component	cytoplasm; cell cortex; brush border; extracellular exosome; cytoskeleton; podosome; cell junction; cell projection; plasma membrane; protein-containing complex;
Biological process	sequestering of actin monomers; regulation of chondrocyte differentiation; actin nucleation; actin filament severing; positive regulation of actin nucleation; positive regulation of secretion; actin filament capping; positive regulation of apoptotic process; positive regulation of megakaryocyte differentiation; negative regulation of cell population proliferation; calcium-ion regulated exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	85477
	20259
	ENSG00000006747
	ENSMUSG00000002565
	Q9Y6U3
	Q60604
	NM_001112706; NM_033128
	NM_001146196; NM_009132
	NP_001106177; NP_149119
	NP_001139668; NP_033158
	Wikidata
View/Edit Human	View/Edit Mouse

Scinderin (also known as adseverin) is a protein that in humans is encoded by the SCIN gene.^[5] Scinderin is an actin severing protein belonging to the gelsolin superfamily.^[6] It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada. Secretory tissues are rich in scinderin. In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are excluded from release sites on the plasma membrane by the presence of a cortical actin filament network. During cell stimulation, calcium channels open allowing calcium ions to enter the secretory cell. Increase in intracellular calcium activates scinderin with the consequent actin filament severing and local dissociation of actin filament networks. This allows the movement of secretory vesicles to release sites on the plasma membrane.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006747 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002565 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SCIN scinderin".
^ Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006747 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002565 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SCIN scinderin".

[6] Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

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