negative regulation of extrinsic apoptotic signaling pathway
receptor-mediated endocytosis
dendritic spine maintenance
focal adhesion assembly
actin filament polymerization
regulation of autophagy of mitochondrion
lamellipodium organization
intracellular protein transport
positive regulation of smooth muscle contraction
membrane organization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2017
13043
Ensembl
ENSG00000085733 ENSG00000288401
ENSMUSG00000031078
UniProt
Q14247
Q60598
RefSeq (mRNA)
NM_001184740 NM_005231 NM_138565
NM_001252572 NM_007803 NM_001357116
RefSeq (protein)
NP_001171669 NP_005222 NP_612632
NP_001239501 NP_031829 NP_001344045
Location (UCSC)
Chr 11: 70.4 – 70.44 Mb
Chr 7: 143.99 – 144.02 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cortactin (from "cortical actin binding protein") is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery.[5][6] It is present in all cell types. When activated, it will recruit Arp2/3 complex proteins to existing actin microfilaments, facilitating and stabilizing nucleation sites for actin branching. Cortactin is important in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis.
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031078 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cosen-Binker LI, Kapus A (October 2006). "Cortactin: the gray eminence of the cytoskeleton". Physiology. 21 (5): 352–61. doi:10.1152/physiol.00012.2006. PMID 16990456.
Cortactin (from "cortical actin binding protein") is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to...
Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene. This gene encodes a protein with six ankyrin repeats and several...
Another molecule that is often found in polymerizing actin with Arp2/3 is cortactin, which appears to link tyrosine kinase signalling to cytoskeletal reorganization...
particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative...
Shao L, Chen YW (Mar 2001). "CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor...
microtubule-associated enzyme. HDAC6 deacetylates tubulin, Hsp90, and cortactin, and forms complexes with other partner proteins, and is, therefore, involved...
Studies related to this protein are as follows: Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. F-actin...
immunohistochemistry for the invadopodia localizing proteins such as cortactin, actin, Tks5 etc. Invadopodia can also be used as a marker to quantify...
M304514200. PMID 12944407. Lua BL, Low BC (2004). "BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell...
Takahisa M, Ueda R, Hashimoto N, Kobayashi M, Togashi S (Nov 1998). "Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila...
PMID 25699257. Clark ES, Whigham AS, Yarbrough WG, et al. (May 2007). "Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular...
"Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochemical and Biophysical Research...
actin assembly and protrusion. ACTR3 has been shown to interact with Cortactin. GRCh38: Ensembl release 89: ENSG00000115091 – Ensembl, May 2017 GRCm38:...
autosomal-dominant polycystic kidney disease, and with F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in...
Gundelfinger ED (August 1999). "Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched...
(Wiskott–Aldrich syndrome protein) are used as markers alongside actin, cortactin and the Arp2/3 complex to localize and isolate these protrusions because...
Another interaction partner of FGD1 is cortactin, which is directly bound by the proline-rich domain of FGD1. As cortactin is known to promote actin polymerization...
tyrosine-phosphorylated proteins, including BCAR1, DOK1, beta-catenin and cortactin have also been described as PTP1B substrates. The first crystal structure...
Makhov AM, Schafer DA, Bear JE (September 2008). "Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia". Cell....
nature has not been determined. ARPC2 has been shown to interact with Cortactin. GRCh38: Ensembl release 89: ENSG00000163466 – Ensembl, May 2017 GRCm38:...
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