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Phenylacetone monooxygenase information


Phenylacetone monooxygenase
Identifiers
EC no.1.14.13.92
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In enzymology, a phenylacetone monooxygenase (EC 1.14.13.92) is an enzyme that catalyzes the chemical reaction

phenylacetone + NADPH + H+ + O2 benzyl acetate + NADP+ + H2O

The 4 substrates of this enzyme are phenylacetone, NADPH, H+, and O2, whereas its 3 products are benzyl acetate, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is phenylacetone,NADPH:oxygen oxidoreductase. This enzyme is also called PAMO.

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Phenylacetone monooxygenase

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4-hydroxyphenylacetone, benzoic acid, hippuric acid, norephedrine, and phenylacetone. Among these metabolites, the active sympathomimetics are 4-hydroxyamphetamine...

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