Good (with treatment), death in ~ 5 years (without treatment)[3]
Frequency
Rare (developed world), relatively common (developing world)[3]
Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B3).[2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth.[1] Areas of the skin exposed to friction and radiation are typically affected first.[1] Over time affected skin may become darker, stiffen, peel, or bleed.[1][3]
There are two main types of pellagra, primary and secondary.[1] Primary pellagra is due to a diet that does not contain enough niacin and tryptophan.[1] Secondary pellagra is due to a poor ability to use the niacin within the diet.[1] This can occur as a result of alcoholism, long-term diarrhea, carcinoid syndrome, Hartnup disease, and a number of medications such as isoniazid.[1] Diagnosis is typically based on symptoms and may be assisted by urine testing.[3]
Treatment is with either niacin or nicotinamide supplementation.[1] Improvements typically begin within a couple of days.[1] General improvements in diet are also frequently recommended.[3] Decreasing sun exposure via sunscreen and proper clothing is important while the skin heals.[1] Without treatment death may occur.[3] The disease occurs most commonly in the developing world, often as a disease of poverty associated with malnutrition, specifically sub-Saharan Africa.[3]
^ abcdefghijklmNgan, Vanessa (2003). "Pellagra". DermNet New Zealand. Archived from the original on 9 April 2017. Retrieved 10 June 2017.
^ ab"Orphanet: Pellagra". orpha.net. Archived from the original on 17 April 2017. Retrieved 10 June 2017.
Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B3). Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth....
dietary supplement is used to treat pellagra, a disease caused by niacin deficiency. Signs and symptoms of pellagra include skin and mouth lesions, anemia...
dietary supplement is used to treat pellagra, a disease caused by niacin deficiency. Signs and symptoms of pellagra include skin and mouth lesions, anemia...
(or "vitamines") as critical in fighting significant diseases such as pellagra and rickets, and his analysis influenced a major shift in scientific thinking...
are made more available for human absorption, thus helping to prevent pellagra.: §5.2 Some of the corn oil is broken down into emulsifying agents (monoglycerides...
four times for the Nobel Prize for his important work on the link between pellagra and poor diet. Goldberger was born in Girált, Sáros County, Kingdom of...
supplement, it is used orally (swallowed by mouth) to prevent and treat pellagra (niacin deficiency). While nicotinic acid (niacin) may be used for this...
Hartnup disease (also known as "pellagra-like dermatosis" and "Hartnup disorder") is an autosomal recessive metabolic disorder affecting the absorption...
erythematosus. More rarely, it is also seen in other diseases, such as pellagra, dermatomyositis, and Bloom syndrome. A malar rash of lupus is red or purplish...
source of caloric intake. Though pellagra predominantly occurs in developing countries, sporadic cases of pellagra may be observed within industrialized...
niacin, the lack of which caused pellagra. Once alkali processing and dietary variety were understood and applied, pellagra disappeared in the developed world...
traumatic injuries, central chromatolysis may be caused by vitamin deficiency (pellagra). Motor neuron Neuropathology - Basic Reactions. University of Vermont...
B1). Funk proposed the hypothesis that other diseases, such as rickets, pellagra, coeliac disease, and scurvy could also be cured by vitamins. Max Nierenstein...
water, and a diet heavily reliant on its consumption is a risk factor for pellagra. The ground product can be called masa nixtamalera. In Central American...
deficiency in humans the condition was sometimes called "pellagra sine pellagra" (pellagra without pellagra). In 1935, Paul Gyorgy, in collaboration with chemist...
deficiency of the tryptophan amino acid transporter, which results in pellagra. Secretion is the reverse of reabsorption: molecules are transported from...
redness and darkening of the skin around the neck, seen in people with pellagra. It becomes prominent following exposure to sun, and can be itchy with...
the full range of essential nutrients. The nutrient-deficiency disease pellagra is associated with a diet consisting primarily of maize, while the disease...
HIV, influenza, or neurosyphilis. Certain vitamin deficiencies such as pellagra (niacin deficiency), vitamin B12 deficiency, folate deficiency, and Wernicke–Korsakoff...
theories on the nature of diseases such as sleeping sickness, malaria, pellagra, and cancer. Sambon was born in Milan to an Italian father and an English...
informants from the Southern United States, speculated that the prevalence of pellagra in the region during the Great Depression may have contributed to the rise...
general in the Israel Defense Forces Joseph Goldberger, discovered cure for pellagra Juraj Herz, actor and film director Ignác Kolisch, chess player Peter Lorre...
vomit). Conditions that can cause saliva overproduction include: Rabies Pellagra (niacin or Vitamin B3 deficiency) Gastroesophageal reflux disease, in such...
started), a program which substantially reduced the incidence of pellagra. Pellagra was seen amongst poor families who used corn as their main dietary...
I; Dibari, Filippo; et al. (2007). "Low and deficient niacin status and pellagra are endemic in postwar Angola". The American Journal of Clinical Nutrition...
contribute to fatigue. Less common symptoms include malabsorption (leading to pellagra), fatigue, muscle loss, and cognitive impairment. Late complications may...
(NR) as an NAD precursor in eukaryotes developed out of the study of pellagra. Pellagra was the first disease to be associated with NAD+ deficiency. It was...
diseases. In the 1930s, he contributed significantly to finding a cure for pellagra, a nutritional disease that once afflicted millions in the American South...
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