Micrograph of the anterior horn of the spinal cord showing motor neurons with central chromatolysis. H&E stain.Micrograph of the anterior horn of the spinal cord showing motor neurons with central chromatolysis. Neurofilament immunostain.
Central chromatolysis is a histopathologic change seen in the cell body of a neuron, where the chromatin and cell nucleus are pushed to the cell periphery, in response to axonal injury.[1][2]
This response is associated with increased protein synthesis to accommodate for axonal sprouting.
In addition to traumatic injuries, central chromatolysis may be caused by vitamin deficiency (pellagra[3]).
^Neuropathology - Basic Reactions. University of Vermont. URL: http://www.uvm.edu/~jkessler/NP/neuropbr.htm Archived January 1, 2010, at the Wayback Machine. Accessed on: 1 January 2011.
through regeneration can occur after chromatolysis, but most often it is a precursor of apoptosis. The event of chromatolysis is also characterized by a prominent...
Centralchromatolysis is a histopathologic change seen in the cell body of a neuron, where the chromatin and cell nucleus are pushed to the cell periphery...
and require additional manual segmentation to measure. Betz cell Centralchromatolysis Motor dysfunction Motor neuron disease Nerve Sensory nerve Motor...
mild form of diffuse axonal injury. Axonal injury can also cause centralchromatolysis. The dysfunction of axons in the nervous system is one of the major...
intermediate filament proteins, the neurofilament proteins all share a common central alpha helical region, known as the rod domain because of its rod-like tertiary...
requires an increased metabolic activity and is initiated by chromatolysis. Chromatolysis is characterized as the dissolution of protein-producing structures...
neurotransmitters are created. The nucleus of the damaged axon undergoes chromatolysis in preparation for axon regeneration. Schwann cells in the distal stump...
guiding the regrowing axon. At the neuronal cell body, a process called chromatolysis occurs in which the nucleus migrates to the periphery of the cell body...
Global Information
