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Nicotinamide riboside information


Nicotinamide riboside
Names
IUPAC name
3-Carbamoyl-1-(β-D-ribofuranosyl)pyridin-1-ium
Systematic IUPAC name
3-Carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium
Other names
1-(β-D-Ribofuranosyl)nicotinamide; N-Ribosylnicotinamide
Identifiers
CAS Number
  • 1341-23-7 checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:15927
ChemSpider
  • 388956
PubChem CID
  • 439924
UNII
  • 0I8H2M0L7N checkY
CompTox Dashboard (EPA)
  • DTXSID501010039 Edit this at Wikidata
InChI
  • InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18
SMILES
  • c1cc(c[n+](c1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N
Properties
Chemical formula
C11H15N2O5+
Molar mass 255.25 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Nicotinamide riboside (NR, SR647) is a pyridine-nucleoside and a form of vitamin B3. It functions as a precursor to nicotinamide adenine dinucleotide, or NAD+,[1] through a two-step and a three-step pathway.[2]

  1. ^ Bogan, KL; Brenner, C (2008). "Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition". Annu. Rev. Nutr. 28: 115–130. doi:10.1146/annurev.nutr.28.061807.155443. PMID 18429699.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Mehmel, M; Jovanović, N; Spitz, U (31 May 2020). "Nicotinamide Riboside-The Current State of Research and Therapeutic Uses". Nutrients. 12 (6): 1616. doi:10.3390/nu12061616. PMC 7352172. PMID 32486488.

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Nicotinamide riboside

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Nicotinamide riboside (NR, SR647) is a pyridine-nucleoside and a form of vitamin B3. It functions as a precursor to nicotinamide adenine dinucleotide,...

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Nicotinamide adenine dinucleotide

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salvage metabolic pathways are nicotinic acid (NA), nicotinamide (Nam) and nicotinamide riboside (NR). These compounds can be taken up from the diet and...

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Nicotinamide mononucleotide

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Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose, nicotinamide, nicotinamide riboside and niacin. In humans, several...

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Vitamin B3

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(nicotinic acid), nicotinamide (niacinamide), and nicotinamide riboside. All three forms of vitamin B3 are converted within the body to nicotinamide adenine dinucleotide...

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ChromaDex

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Cornell University, and Washington University in St. Louis regarding nicotinamide riboside, which it markets and sells as an ingredient under the brand name...

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B vitamins

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NADP, which are needed in many metabolic processes. Niacinamide Nicotinamide riboside Vitamin B5 Pantothenic acid A precursor of coenzyme A and therefore...

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Nicotinamide phosphoribosyltransferase

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Nicotinamide phosphoribosyltransferase (NAmPRTase or NAMPT), formerly known as pre-B-cell colony-enhancing factor 1 (PBEF1) or visfatin for its extracellular...

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Elysium Health

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2015, Elysium introduced its first product, Basis, which contains nicotinamide riboside and pterostilbene. In December 2016, Elysium received an investment...

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Vitamin

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bananas, green beans, asparagus B3 nicotinic acid niacinamide nicotinamide riboside water 16 mg/14 mg pellagra liver damage (doses > 2g/day) and other...

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Vitamer

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beta-carotene are not associated with these toxic effects. Nicotinic acid and nicotinamide are two vitamers of vitamin B3 that exhibit differences in metabolism...

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Mitochondrial unfolded protein response

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nematode worms by increasing NAD+ by supplementation with nicotinamide or nicotinamide riboside has been shown to extend lifespan. Glial and germline mitochondria...

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Medicinal uses of fungi

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lovastatin, mevastatin, and the simvastatin precursor monacolin J. Nicotinamide riboside, a cholesterol biosynthesis inhibitor, is made by Saccharomyces...

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NR

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NR) Nuclear receptor, a class of receptor proteins in the cell Nicotinamide riboside, a form of Vitamin B3 Reactive nitrogen (Nr) .nr, the top-level...

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NNMT

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Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene. NNMT catalyzes the methylation of nicotinamide and similar...

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NMNAT1

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PMID 28445802. Fletcher RS, Lavery GG (2018). "The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism". Journal of Molecular...

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AICA ribonucleotide

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determined, to interpret test results. Inosine monophosphate synthase Nicotinamide riboside Zarembo, Alan (1 August 2008). "'Exercise pill' could take the work...

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Nicotinamide ribonucleoside uptake transporters

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(P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae". Journal of Bacteriology...

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Aging brain

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of pharmacological strategies are under investigation, including nicotinamide riboside Caloric restriction and intermittent fasting[additional citation(s)...

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Ribosylnicotinamide kinase

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Bieganowski, Pawel & Brenner, Charles. (2004). Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler...

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ITGB1BP3

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Nicotinamide riboside kinase 2 is an enzyme that in humans is encoded by the ITGB1BP3 gene. ITGB1BP3 has been shown to interact with ST7. GRCh38: Ensembl...

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Nicotinate riboside kinase

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Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C (October 2007). "Nicotinamide riboside kinase structures reveal new pathways to NAD+". PLOS Biology. 5...

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PARP16

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of protein serine/threonine kinase activity NAD biosynthesis via nicotinamide riboside salvage pathway cellular response to leukemia inhibitory factor...

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MTAP

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methylthioadenosine purine ribonucleoside salvage nucleoside metabolic process nicotinamide riboside catabolic process nucleobase-containing compound metabolic process...

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Renalase

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aberrant NADH and NADPH forms that are not accepted as cofactors by most nicotinamide-dependent oxidoreductase enzymes. It transpired that α-NAD(P)H molecules...

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