Paraoxon is a parasympathomimetic which acts as an cholinesterase inhibitor. It is an organophosphate oxon, and the active metabolite of the insecticide parathion. It is also used as an ophthalmological drug against glaucoma. Paraoxon is one of the most potent acetylcholinesterase-inhibiting insecticides available, around 70% as potent as the nerve agent sarin, and so is now rarely used as an insecticide due to the risk of poisoning to humans and other animals. Paraoxon has been used by scientists to study acute and chronic effects of organophosphate intoxication.[1][2] It is easily absorbed through skin, and was allegedly used as an assassination weapon by the apartheid-era South African chemical weapons program Project Coast.[3]
^Deshpande LS, Carter DS, Phillips KF, Blair RE, DeLorenzo RJ (September 2014). "Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication". Neurotoxicology. 44: 17–26. doi:10.1016/j.neuro.2014.04.006. PMC 4176600. PMID 24785379.
^Deshpande LS, Phillips K, Huang B, DeLorenzo RJ (September 2014). "Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity". Neurotoxicology. 44: 352–7. doi:10.1016/j.neuro.2014.08.008. PMC 4175062. PMID 25172410.
^NTI Country Overviews:South Africa:Chemical Capabilities:Paraoxon Archived 2008-07-08 at the Wayback Machine
Paraoxon is a parasympathomimetic which acts as an cholinesterase inhibitor. It is an organophosphate oxon, and the active metabolite of the insecticide...
Diisopropyl paraoxon is an organophosphate that inhibits the acetylcholinesterase. It is the isopropyl analog of paraoxon. Diisopropyl paraoxon is insoluble...
Absorbed parathion is rapidly metabolized to paraoxon, as described in Insecticidal activity. Paraoxon exposure can result in headaches, convulsions...
Aryldialkylphosphatase (also known as organophosphorus hydrolase, phosphotriesterase, and paraoxon hydrolase) uses an aryl dialkyl phosphate and H2O to produce dialkyl phosphate...
insecticide paraoxon and parathion. It's the structural isomer of parathion. Parathion S is a potent acetylcholinesterase inhibitor. Paraoxon Parathion...
pyrophosphoramide (Iso-OMPA) and ethopropazine are selective BChE inhibitors. Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase...
drops", digoxin, acetylcholinesterase inhibitors such as aldicarb and paraoxon and other poisons. Other plans referenced in the UN report included crowd...
government attempted to assassinate Chikane by lacing his underwear with Paraoxon. Two of the suspects were former Police Minister Adriaan Vlok and his then-police...
as other nerve agents. Some insecticides such as demeton, dimefox and paraoxon are sufficiently toxic to humans that they have been withdrawn from agricultural...
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