Mouse pancreatic islets a potential region where Pancreatic progenitors reside
Details
Precursor
Foregut endoderm
Identifiers
Latin
Cellula pancreaticum praecursoria
TH
H2.00.01.0.00005
Anatomical terms of microanatomy
[edit on Wikidata]
Pancreatic progenitor cells are multipotent stem cells originating from the developing fore-gut endoderm which have the ability to differentiate into the lineage specific progenitors responsible for the developing pancreas.[1][2]
They give rise to both the endocrine and exocrine cells. Exocrine cells constitute the acinar cells and the ductal cells. The endocrine cells constitute the beta cells which make insulin, alpha cells which secrete glucagon, delta cells which secrete somatostatin and the PP-cells which secrete pancreatic polypeptide.[3]
Pancreatic progenitor cells have been shown to arise from cells originating from the developing foregut during mammalian development.[4][5] It has been seen in the developing embryo at stages E9.0 to E9.5 that there are a cluster of cells which give rise to the pancreas. These clusters have been characterized to show multipotent properties.[6]
The development and differentiation of the pancreatic progenitor cell. Note the changing expression pattern of markers
^Ku, H. T. (2008). "Pancreatic progenitor cells—recent studies". Endocrinology. 149 (9): 4312–4316. doi:10.1210/en.2008-0546. PMC 2553367. PMID 18535096.
^Noguchi, H (2010). "Pancreatic stem/progenitor cells for the treatment of diabetes". Rev Diabet Stud. 7 (2): 105–111. doi:10.1900/RDS.2010.7.105. PMC 2989783. PMID 21060969.
^Cabrera, O.; berman, D.M.; Kenyon, N.S.; Ricordi, C.; Berggren, P-O.; Caicedo (2006). "The unique cytoarchitecture of human pancreatic islets has implications for islet cell function". PNAS. 7 (103): 2334–2339. Bibcode:2006PNAS..103.2334C. doi:10.1073/pnas.0510790103. PMC 1413730. PMID 16461897.
^Bhushan, A.; Itoh, N.; Kato, S.; Thiery, J. P.; Czernichow, P.; Bellusci, S.; Scharfmann, R. (2001). "Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis". Development. 128 (24): 5109–5117. doi:10.1242/dev.128.24.5109. PMID 11748146.
^Wells, J. M.; Melton, D. A. (1999). "Vertebrate endoderm development". Annual Review of Cell and Developmental Biology. 15 (1): 393–410. doi:10.1146/annurev.cellbio.15.1.393. PMID 10611967.
^Ku, H. T. (2008). "Pancreatic progenitor cells—recent studies". Endocrinology. 149 (9): 4312–4316. doi:10.1210/en.2008-0546. PMC 2553367. PMID 18535096.
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The initial pancreatic bud is composed of Pdx1+ pancreaticprogenitorcells that co-express Hlxb9, Hnf6, Ptf1a and NKX6-1. These cells further proliferate...
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innate lymphoid progenitor, which is downstream of the common lymphoid progenitor from which B and T lymphocytes are also derived. NK cells are known to...
mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent state or progenitorcell type. It is a...
(August 2010). "Activation of pancreatic-duct-derived progenitorcells during pancreas regeneration in adult rats". Journal of Cell Science. 123 (Pt 16): 2792–2802...
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to increase blood cell production. At the cellular level, the main functional component of bone marrow includes the progenitorcells which are destined...
type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost...
Islet resident macrophages are the predominant myeloid cell of the pancreatic islets of langerhans. Islet resident macrophages are uniquely found within...
there are two main principles by which cells facilitate therapeutic action: Stem, progenitor, or mature cell engraftment, differentiation, and long-term...
interact with uncommitted epithelial progenitors to affect their lineage selection toward goblet and tuft cells. As a result, the IL-13 is responsible...
cell with other cells. Certain combinations of mutations in the given progenitorcell ultimately result in that cell (also called a cancer stem cell)...
adult human body is estimated to contain about 30 trillion (3×1013) human cells, with the number varying between 20 to 40 trillion depending on factors...
AST-OPC1 is a population of cells derived from human embryonic stem cells (hESCs) that contains oligodendrocyte progenitorcells (OPCs). OPCs and their mature...
activated conventional T cells and thus does not specifically identify human Tregs. All T cells derive from progenitorcells in the bone marrow, which...
injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitorcells". Science Translational Medicine. 12 (536): eaaw6003...
sites that contribute to the formation of haematopoietic stem and progenitorcells (HSPCs), including the yolk sac, allantois, placenta, para-aortic splanchnopleura...
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