PDX1 information

PDX1
Identifiers
Aliases	PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1, pancreatic and duodenal homeobox 1
External IDs	OMIM: 600733; MGI: 102851; HomoloGene: 175; GeneCards: PDX1; OMA:PDX1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	27,926,313 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	147,212,658 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; body of pancreas; ; duodenum; ; gallbladder; ; liver; ; rectum; ; right lobe of liver; ; stomach; ; kidney; ; body of stomach;
	Top expressed in
	primordial pancreas; ; endocrine pancreas; ; islet of Langerhans; ; duodenum; ; Pancreatic bud; ; pyloric antrum; ; humerus; ; Meckel's cartilage; ; primary oocyte; ; mucous cell of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding; protein-containing complex binding; protein heterodimerization activity; promoter-specific chromatin binding;
Cellular component	cytoplasm; cytosol; nuclear speck; intracellular anatomical structure; nucleus; nucleoplasm;
Biological process	exocrine pancreas development; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; cell differentiation; regulation of transcription, DNA-templated; glucose homeostasis; regulation of transcription by RNA polymerase II; insulin secretion; negative regulation of transcription by RNA polymerase II; generation of precursor metabolites and energy; transcription, DNA-templated; multicellular organism development; positive regulation of transcription, DNA-templated; regulation of cell population proliferation; positive regulation of cell population proliferation; nitric oxide mediated signal transduction; glucose metabolic process; animal organ morphogenesis; pancreas development; liver development; positive regulation of insulin secretion involved in cellular response to glucose stimulus; morphogenesis of embryonic epithelium; digestive tract development; negative regulation of type B pancreatic cell apoptotic process; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; endocrine pancreas development; type B pancreatic cell differentiation; transcription by RNA polymerase II; detection of glucose; smoothened signaling pathway; central nervous system development; response to wounding; response to glucose; response to iron(II) ion; response to chlorate; regulation of gene expression; positive regulation of cell death; response to organic cyclic compound; animal organ regeneration; response to nutrient levels; positive regulation of insulin secretion; response to vitamin; response to lipid; response to cytokine; response to nicotine; response to leucine; response to alkaloid; positive regulation of DNA binding; negative regulation of transcription, DNA-templated; stem cell differentiation; response to glucocorticoid; transdifferentiation; response to fatty acid;
	Sources:Amigo / QuickGO
Orthologs
	3651
	18609
	ENSG00000139515
	ENSMUSG00000029644
	P52945
	P52946
	NM_000209
	NM_008814
	NP_000200
	NP_032840
	Wikidata
View/Edit Human	View/Edit Mouse

PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster.^[5] In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1.^[6]^[7] The gene was originally identified in the clawed frog Xenopus laevis ^[8] and is present widely across the evolutionary diversity of bilaterian animals, although it has been lost in evolution in arthropods and nematodes.^[5] Despite the gene name being Pdx1, there is no Pdx2 gene in most animals; single-copy Pdx1 orthologs have been identified in all mammals.^[9] Coelacanth and cartilaginous fish are, so far, the only vertebrates shown to have two Pdx genes, Pdx1 and Pdx2.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139515 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029644 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Brooke, N. M., Garcia-Fernàndez, J., & Holland, P. W. (1998). The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster. Nature, 392(6679), 920.
^ "PDX1". HGNC. Retrieved 22 April 2016.
^ Stoffel M, Stein R, Wright CV, Espinosa R, Le Beau MM, Bell GI (July 1995). "Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1". Genomics. 28 (1): 125–6. doi:10.1006/geno.1995.1120. PMID 7590740.
^ Wright, C. V., Schnegelsberg, P., & De Robertis, E. M. (1989). XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. Development, 105(4), 787-794.
^ "OrthoMaM phylogenetic marker: PDX1 coding sequence". OrthoMam v10. 2019. Retrieved 24 February 2019.
^ Mulley JF, Holland PW (October 2010). "Parallel retention of Pdx2 genes in cartilaginous fish and coelacanths". Molecular Biology and Evolution. 27 (10): 2386–91. doi:10.1093/molbev/msq121. PMC 2944030. PMID 20463047.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139515 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029644 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Brooke1998-5] Brooke, N. M., Garcia-Fernàndez, J., & Holland, P. W. (1998). The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster. Nature, 392(6679), 920.

[6] "PDX1". HGNC. Retrieved 22 April 2016.

[pmid7590740-7] Stoffel M, Stein R, Wright CV, Espinosa R, Le Beau MM, Bell GI (July 1995). "Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1". Genomics. 28 (1): 125–6. doi:10.1006/geno.1995.1120. PMID 7590740.

[8] Wright, C. V., Schnegelsberg, P., & De Robertis, E. M. (1989). XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. Development, 105(4), 787-794.

[OrthoMaM-9] "OrthoMaM phylogenetic marker: PDX1 coding sequence". OrthoMam v10. 2019. Retrieved 24 February 2019.

[10] Mulley JF, Holland PW (October 2010). "Parallel retention of Pdx2 genes in cartilaginous fish and coelacanths". Molecular Biology and Evolution. 27 (10): 2386–91. doi:10.1093/molbev/msq121. PMC 2944030. PMID 20463047.

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