negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
cell differentiation
regulation of transcription, DNA-templated
glucose homeostasis
regulation of transcription by RNA polymerase II
insulin secretion
negative regulation of transcription by RNA polymerase II
generation of precursor metabolites and energy
transcription, DNA-templated
multicellular organism development
positive regulation of transcription, DNA-templated
regulation of cell population proliferation
positive regulation of cell population proliferation
nitric oxide mediated signal transduction
glucose metabolic process
animal organ morphogenesis
pancreas development
liver development
positive regulation of insulin secretion involved in cellular response to glucose stimulus
morphogenesis of embryonic epithelium
digestive tract development
negative regulation of type B pancreatic cell apoptotic process
negative regulation of cell population proliferation
positive regulation of transcription by RNA polymerase II
endocrine pancreas development
type B pancreatic cell differentiation
transcription by RNA polymerase II
detection of glucose
smoothened signaling pathway
central nervous system development
response to wounding
response to glucose
response to iron(II) ion
response to chlorate
regulation of gene expression
positive regulation of cell death
response to organic cyclic compound
animal organ regeneration
response to nutrient levels
positive regulation of insulin secretion
response to vitamin
response to lipid
response to cytokine
response to nicotine
response to leucine
response to alkaloid
positive regulation of DNA binding
negative regulation of transcription, DNA-templated
stem cell differentiation
response to glucocorticoid
transdifferentiation
response to fatty acid
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3651
18609
Ensembl
ENSG00000139515
ENSMUSG00000029644
UniProt
P52945
P52946
RefSeq (mRNA)
NM_000209
NM_008814
RefSeq (protein)
NP_000200
NP_032840
Location (UCSC)
Chr 13: 27.92 – 27.93 Mb
Chr 5: 147.21 – 147.21 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster.[5] In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1.[6][7] The gene was originally identified in the clawed frog Xenopus laevis[8] and is present widely across the evolutionary diversity of bilaterian animals, although it has been lost in evolution in arthropods and nematodes.[5] Despite the gene name being Pdx1, there is no Pdx2 gene in most animals; single-copy Pdx1 orthologs have been identified in all mammals.[9] Coelacanth and cartilaginous fish are, so far, the only vertebrates shown to have two Pdx genes, Pdx1 and Pdx2.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000139515 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029644 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abBrooke, N. M., Garcia-Fernàndez, J., & Holland, P. W. (1998). The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster. Nature, 392(6679), 920.
^"PDX1". HGNC. Retrieved 22 April 2016.
^Stoffel M, Stein R, Wright CV, Espinosa R, Le Beau MM, Bell GI (July 1995). "Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1". Genomics. 28 (1): 125–6. doi:10.1006/geno.1995.1120. PMID 7590740.
^Wright, C. V., Schnegelsberg, P., & De Robertis, E. M. (1989). XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. Development, 105(4), 787-794.
^Mulley JF, Holland PW (October 2010). "Parallel retention of Pdx2 genes in cartilaginous fish and coelacanths". Molecular Biology and Evolution. 27 (10): 2386–91. doi:10.1093/molbev/msq121. PMC 2944030. PMID 20463047.
PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates...
bullet in its Supreme Elite line of handgun ammunition called the Bonded PDX1. It is similar to the Ranger SXT series and the older Black Talon design...
transcription factors influencing insulin secretion are PDX1, NeuroD1, and MafA. During a low-glucose state, PDX1 (pancreatic and duodenal homeobox protein 1) is...
developing pancreas.[citation needed] Pdx1 is accepted as the earliest marker for pancreatic differentiation. Pdx1 has been shown to be a marker for all...
"Winchester jacketed hollow-point" round; similar in appearance to the Winchester PDX1 round but with some differences to the design of the hollow-point petals...
MODY 4 or PDX1-MODY is a form of maturity onset diabetes of the young. MODY 4 arises from mutations of the PDX1 homeobox gene on chromosome 13. Pdx-1...
human genome has six ParaHox genes (GSX1, GSX2, PDX1, CDX1, CDX2, CDX4), of which three genes (GSX1, PDX1 (=IPF1), CDX2) are physically linked to form a...
lower pressures compared to .40 S&W. The APD has standardized Winchester PDX1 147 grain 9mm ammunition. The APD also trains and issues the AR-15 to many...
from diabetic patient, cultured and expanded ex vivo, transduced with a PDX1 virus, transdifferentiated into functional insulin-producing beta cells,...
Sequencing of the complete nuclear DNA genome of Psammomys obesus showed that the Pdx1 homeobox gene, a transcriptional activator of insulin, has undergone massive...
cells are characterised by the co-expression of the transcription factors PDX1 and NKX6-1. The cells of the exocrine pancreas differentiate through molecules...
duplicates the properties of the historical loads. As an example Winchester's PDX1 12 gauge load features three 00-buck copper plated pellets over a one-ounce...
(March 2011). "The role of the pyridoxine (vitamin B6) biosynthesis enzyme PDX1 in ultraviolet-B radiation responses in plants". Plant Physiol Biochem. 49...
low-glucose conditions, Pdx1 could recruit co-repressors HDAC1/2, which led to inhibition of insulin gene expression. Furthermore, Pdx1 also mediated β-cell-specific...
however it is not significant to the ventral bud. Another homedomain protein, PDX1 (also known as Ipf-1 insulin promoter factor 1) is the initiator of buds...
analogously found in four areas. They include CDX1, CDX2, CDX4; GSX1, GSX2; and PDX1. Other genes considered Hox-like include EVX1, EVX2; GBX1, GBX2; MEOX1, MEOX2;...
specific TF according to literature or domain structure – No motif [688] PDX1 ENSG00000139515 Homeodomain Known motif – High-throughput in vitro [689]...
regions of the gut tube. Thus, SOX2 specifies the esophagus and stomach; PDX1 specifies the duodenum; CDXC specifies the small intestine; CDXA specifies...
Global Information
