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Transdifferentiation, also known as lineage reprogramming,[1] is the process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type.[2] It is a type of metaplasia, which includes all cell fate switches, including the interconversion of stem cells. Current uses of transdifferentiation include disease modeling and drug discovery and in the future may include gene therapy and regenerative medicine.[3] The term 'transdifferentiation' was originally coined by Selman and Kafatos[4] in 1974 to describe a change in cell properties as cuticle producing cells became salt-secreting cells in silk moths undergoing metamorphosis.[5]
^Orkin, S. H.; Zon, L. I. (2008). "Hematopoiesis: An Evolving Paradigm for Stem Cell Biology". Cell. 132 (4): 631–644. doi:10.1016/j.cell.2008.01.025. PMC 2628169. PMID 18295580.
^Graf, T.; Enver, T. (2009). "Forcing cells to change lineages". Nature. 462 (7273): 587–594. Bibcode:2009Natur.462..587G. doi:10.1038/nature08533. PMID 19956253. S2CID 4417323.
^Pournasr, B.; Khaloughi, K.; Salekdeh, G. H.; Totonchi, M.; Shahbazi, E.; Baharvand, H. (2011). "Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933–1941. doi:10.1002/stem.760. PMID 21997905.
^Selman, Kelly; Kafatos, Fotis C. (1974-07-01). "Transdifferentiation in the labial gland of silk moths: is DNA required for cellular metamorphosis?". Cell Differentiation. 3 (2): 81–94. doi:10.1016/0045-6039(74)90030-X. PMID 4277742.
^Selman, K.; Kafatos, F. C. (2013). "Transdifferentiation in the labial gland of silk moths: Is DNA required for cellular metamorphosis?". Cell Differentiation. 3 (2): 81–94. doi:10.1016/0045-6039(74)90030-x. PMID 4277742.
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process is known as transdifferentiation. The gene Mist1 has been shown to regulate mucus neck cell to chief cell transdifferentiation and plays a role in...
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transcription factors can directly induce other defined somatic cell fates (transdifferentiation); researchers identified three neural-lineage-specific transcription...
found a way to transform human skin cells into nerve cells using transdifferentiation, in which "cells are forced to adopt new identities". During neurogenesis...
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that can substitute for the function of the transcription factors. Transdifferentiation experiments were carried out. They tried to change the cell fate...
a small (5 millimeters (0.20 in)) species of jellyfish that uses transdifferentiation to replenish cells after sexual reproduction. This cycle can repeat...
endoderm and mesoderm. This phenomenon is referred to as stem cell transdifferentiation or plasticity. It can be induced by modifying the growth medium when...
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Induced knockout of DMRT1 in adult male mice has been found to cause transdifferentiation of somatic cells in the testis to the equivalent cell types that...
and remodelling of existing tissues to replace lost parts. Direct transdifferentiation of one type of tissue to another during tissue replacement is also...
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art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification". Bone Research. 6: 19. doi:10.1038/s41413-018-0021-z...
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