Insulin receptor substrate 1 information

IRS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IRS, 1K3A, 1QQG, 2Z8C
Identifiers
Aliases	IRS1, HIRS-1, insulin receptor substrate 1
External IDs	OMIM: 147545 MGI: 99454 HomoloGene: 4049 GeneCards: IRS1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	226,799,820 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	82,269,137 bp
RNA expression pattern
	Top expressed in
	tibia; ; lactiferous duct; ; vastus lateralis muscle; ; biceps brachii; ; stromal cell of endometrium; ; mucosa of urinary bladder; ; parietal pleura; ; Brodmann area 23; ; germinal epithelium; ; periodontal fiber;
	Top expressed in
	calvaria; ; pineal gland; ; triceps brachii muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; body of femur; ; digastric muscle; ; ankle; ; intercostal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor receptor binding; transmembrane receptor protein tyrosine kinase adaptor activity; SH2 domain binding; signal transducer activity; phosphatidylinositol 3-kinase binding; protein binding; protein kinase C binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphotyrosine residue binding; insulin receptor binding;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; caveola; insulin receptor complex; nucleus; cytosol; plasma membrane;
Biological process	positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; insulin-like growth factor receptor signaling pathway; negative regulation of insulin secretion; positive regulation of glycogen biosynthetic process; glucose homeostasis; response to peptide hormone; positive regulation of glucose metabolic process; MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; response to insulin; negative regulation of insulin receptor signaling pathway; positive regulation of cell population proliferation; cellular response to insulin stimulus; phosphatidylinositol 3-kinase signaling; positive regulation of insulin receptor signaling pathway; phosphatidylinositol-mediated signaling; signal transduction; insulin receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; interleukin-7-mediated signaling pathway; positive regulation of protein kinase B signaling; cellular response to fatty acid;
	Sources:Amigo / QuickGO
Orthologs
	3667
	16367
	ENSG00000169047
	ENSMUSG00000055980
	P35568
	P35569
	NM_005544
	NM_010570
	NP_005535
	NP_034700
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the IRS1 gene.^[5] It is a 131 kDa protein with amino acid sequence of 1242 residues.^[6] It contains a single pleckstrin homology (PH) domain at the N-terminus and a PTB domain ca. 40 residues downstream of this, followed by a poorly conserved C-terminus tail.^[7] Together with IRS2, IRS3 (pseudogene) and IRS4, it is homologous to the Drosophila protein chico, whose disruption extends the median lifespan of flies up to 48%.^[8] Similarly, Irs1 mutant mice experience moderate life extension and delayed age-related pathologies.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169047 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055980 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF (July 1991). "Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein". Nature. 352 (6330): 73–7. Bibcode:1991Natur.352...73S. doi:10.1038/352073a0. PMID 1648180. S2CID 4311960.
^ "IRS1 - Insulin receptor substrate 1 - Homo sapiens (Human) - IRS1 gene & protein". www.uniprot.org. Retrieved 2016-04-21.
^ Copps KD, White MF (October 2012). "Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2". Diabetologia. 55 (10): 2565–82. doi:10.1007/s00125-012-2644-8. PMC 4011499. PMID 22869320.
^ Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L (April 2001). "Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein". Science. 292 (5514): 104–6. Bibcode:2001Sci...292..104C. doi:10.1126/science.1057991. PMID 11292874. S2CID 30331471.
^ Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ (March 2008). "Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice". FASEB Journal. 22 (3): 807–18. doi:10.1096/fj.07-9261com. PMID 17928362. S2CID 12387212.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169047 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055980 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1648180-5] Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF (July 1991). "Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein". Nature. 352 (6330): 73–7. Bibcode:1991Natur.352...73S. doi:10.1038/352073a0. PMID 1648180. S2CID 4311960.

[6] "IRS1 - Insulin receptor substrate 1 - Homo sapiens (Human) - IRS1 gene & protein". www.uniprot.org. Retrieved 2016-04-21.

[:2-7] Copps KD, White MF (October 2012). "Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2". Diabetologia. 55 (10): 2565–82. doi:10.1007/s00125-012-2644-8. PMC 4011499. PMID 22869320.

[8] Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L (April 2001). "Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein". Science. 292 (5514): 104–6. Bibcode:2001Sci...292..104C. doi:10.1126/science.1057991. PMID 11292874. S2CID 30331471.

[9] Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ (March 2008). "Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice". FASEB Journal. 22 (3): 807–18. doi:10.1096/fj.07-9261com. PMID 17928362. S2CID 12387212.

Insulin receptor substrate 1 information

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