Ototoxicity is the property of being toxic to the ear (oto-), specifically the cochlea or auditory nerve and sometimes the vestibular system, for example, as a side effect of a drug. The effects of ototoxicity can be reversible and temporary, or irreversible and permanent.
It has been recognized since the 19th century.[1]
There are many well-known ototoxic drugs used in clinical situations, and they are prescribed, despite the risk of hearing disorders, for very serious health conditions.[2]
Ototoxic drugs include antibiotics (such as gentamicin, streptomycin, tobramycin), loop diuretics (such as furosemide), and platinum-based chemotherapy agents (such as cisplatin and carboplatin). A number of nonsteroidal anti-inflammatory drugs (NSAIDS) have also been shown to be ototoxic.[3][4] This can result in sensorineural hearing loss, dysequilibrium, or both. Some environmental and occupational chemicals have also been shown to affect the auditory system and interact with noise.[5]
^Schacht J, Hawkins JE (1 January 2006). "Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss". Audiology and Neuro-Otology. 11 (1): 1–6. doi:10.1159/000088850. PMID 16219991. S2CID 37321714.
^Position Statement and Practice Guidelines on Ototoxicity Monitoring(PDF). American Academy of Audiology. 2009.
^Cazals Y (December 2000). "Auditory sensori-neural alterations induced by salicylate". Progress in Neurobiology. 62 (6): 583–631. doi:10.1016/s0301-0082(00)00027-7. PMID 10880852. S2CID 23196277.
^Jung, T. T.; Rhee, C. K.; Lee, C. S.; Park, Y. S.; Choi, D. C. (October 1993). "Ototoxicity of salicylate, nonsteroidal antiinflammatory drugs, and quinine". Otolaryngologic Clinics of North America. 26 (5): 791–810. doi:10.1016/S0030-6665(20)30767-2. ISSN 0030-6665. PMID 8233489.
^Johnson AC, Morata TC (2010). "Occupational exposure to chemicals and hearing impairment. The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals" (PDF). Arbete och Hälsa. 44 (4): 177. Retrieved 4 May 2016.
of risk for ototoxicity. Loop and thiazide diuretics carry this side effect. The loop diuretic furosemide is associated with ototoxicity, particularly...
nervous system. Onset of ototoxicity ranges from taking a single dose to long-term usage of the drugs. Signs and symptoms of ototoxicity include tinnitus, hearing...
world. Still, the relatively frequent occurrence of nephrotoxicity and ototoxicity during aminoglycoside treatment makes physicians reluctant to use these...
vancomycin ototoxicity are rare. The association between vancomycin serum levels and ototoxicity is also uncertain. While cases of ototoxicity have been...
to assess the severity of ototoxicity. Other drugs (such as the aminoglycoside antibiotic class) may also cause ototoxicity, and the administration of...
(neuropathy) Kidney damage (nephrotoxicity) Ear disorders (ototoxicity) Nephrotoxicity and ototoxicity are thought to be dose related with higher doses causing...
lidocaine and mexiletine are antagonized. Antibacterials: increased risk of ototoxicity with aminoglycosides, polymyxins and vancomycin; avoid concomitant use...
damage and ototoxicity (which can lead to hearing loss) are the most important effects, occurring in 1–10% of users. The nephro- and ototoxicity are thought...
S2CID 13551808. Langman, A. Neomycin ototoxicity. Otolaryngology Head and Neck Surgery 1994, 110, 441-444. Langman, A. Neomycin ototoxicity. Otolaryngology Head and...
sodium thiosulfate under the trade name Pedmark to lessen the risk of ototoxicity and hearing loss in infant, child, and adolescent cancer patients receiving...
(2010). Ototoxic Drugs Exposed (3 ed.). Integrity First Publications. pp. 435–436. ISBN 978-1-935939-00-9. You can develop symptoms of ototoxicity after...
PMID 8526738. S2CID 22919141. Preventing hearing loss caused by chemical (ototoxicity) and noise exposure (PDF) (Report). September 1, 2020. doi:10.26616/NIOSHPUB2018124...
Gagnaire, F.; Marignac, B.; Langlais, C.; Bonnet, P. (July 2001). "Ototoxicity in rats exposed to ortho-, meta- and para-xylene vapours for 13 weeks"...
due to the ototoxicity of hydrocodone. Other researchers have suggested that paracetamol is the primary agent responsible for the ototoxicity. The U.S....
(only seen on blood or urine tests) or may cause acute kidney injury. Ototoxicity (damage to the inner ear) is a common side effect of platinum based drugs...
Lai P, Coulson C, Pothier DD, Rutka J (December 2011). "Chlorhexidine ototoxicity in ear surgery, part 1: review of the literature". Journal of Otolaryngology...
distinct from presbycusis. A second exacerbating factor is exposure to ototoxic drugs and chemicals. Over time, the detection of high-pitched sounds becomes...
individual. There are both external causes of damage, including infection, and ototoxic drugs, as well as intrinsic causes, including genetic mutations. A common...
protect against noise-induced hearing loss (NIHL) and cisplatin-induced ototoxicity. These protective effects are believed to be caused by riluzole's antioxidant...
the evidence was poor. Due to the use of aminoglycoside antibiotics, ototoxicity is common. Symptoms may include "tinnitus, hearing loss, hyperacusis...
gravis. Like other aminoglycosides, a major side effect for tobramycin is ototoxicity or a loss of equilibrioception, or both in genetically susceptible individuals...
(noise trauma), and the second is exposure to drugs and other substances (ototoxicity). A large number of people are exposed to sound levels on a daily basis...
the metabolism of other drugs broken down by this system. Anecdotally, ototoxicity has also been reported if injected too quickly. Use of ondansetron has...
furosemide in patients with heart failure. No evidence of torasemide-induced ototoxicity has been demonstrated in humans. Loop diuretics, including torsemide...
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