Amikacin is an antibiotic medication used for a number of bacterial infections.[9] This includes joint infections, intra-abdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections.[9] It is also used for the treatment of multidrug-resistant tuberculosis.[10] It is used by injection into a vein using an IV or into a muscle.[9]
Amikacin, like other aminoglycoside antibiotics, can cause hearing loss, balance problems, and kidney problems.[9] Other side effects include paralysis, resulting in the inability to breathe.[9] If used during pregnancy it may cause permanent deafness in the baby.[9][1] Amikacin works by blocking the function of the bacteria's 30S ribosomal subunit, making it unable to produce proteins.[9]
Amikacin was patented in 1971, and came into commercial use in 1976.[11][12] It is on the World Health Organization's List of Essential Medicines.[13] It is derived from kanamycin.[9]
^ ab"Amikacin Use During Pregnancy". Drugs.com. 2 December 2019. Retrieved 13 March 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
^"Amikacin 250 mg/ml Injection - Summary of Product Characteristics (SmPC)". (emc). 16 September 2015. Retrieved 13 March 2020.
^Cite error: The named reference Arikayce FDA label was invoked but never defined (see the help page).
^"Arikayce liposomal EPAR". European Medicines Agency. 21 July 2020. Retrieved 4 March 2023.
^"Arikayce liposomal Product information". Union Register of medicinal products. Retrieved 3 March 2023.
^Cite error: The named reference plumb was invoked but never defined (see the help page).
^ abcdefgh"Amikacin Sulfate". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
^World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 137. hdl:10665/44053. ISBN 9789241547659.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 507. ISBN 9783527607495. Archived from the original on 20 December 2016.
^Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford. 2009. p. 56. ISBN 9780191039621. Archived from the original on 24 November 2015.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Amikacin is an antibiotic medication used for a number of bacterial infections. This includes joint infections, intra-abdominal infections, meningitis...
of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains". Ann. Clin....
B Aztreonam (monobactam) Aminoglycosides - particularly tobramycin and amikacin Antibiotics that usually have activity against vancomycin-resistant Enterococcus...
carbapenem) is often the antibiotic of choice. Aminoglycosides such as amikacin have been found to be very effective, as well. Quinolones can be an effective...
[e.g. cefepime, ceftazidime ], or an aminoglycoside [i.e. gentamicin, amikacin]) Antibiotics directed against Gram-positive bacteria need to be included...
when administered with a macrolide and ethambutol, as well as the drugs amikacin and clarithromycin. However, in the United States, clofazimine is considered...
streptomycin is an example of a non-deoxystreptamine aminoglycoside. Kanamycin A Amikacin Tobramycin Dibekacin Gentamicin Sisomicin Netilmicin Neomycins B, C Neomycin...
et al., 2022 as cited in Tavares-Carreon et al., 2023), aminoglycoside amikacin, gentamicin and tobramycin (Bertrand & Dowzicky, 2012; Sader et al., 2014...
pyrazinamide. For drug-resistant TB, a combination of antibiotics such as amikacin, kanamycin, or capreomycin should be used. The most common drugs to treat...
February 2018. Retrieved 22 February 2018. "Drug interactions between amikacin and ampicillin". Drugs.com. Archived from the original on 23 February 2018...
Hattori M (1992). "[Comparative study of cefpiramide + amikacin versus piperacillin + amikacin in granulocytopenic patients: a randomized, prospective...
with multidrug-resistant Klebsiella species, a combination therapy with amikacin and meropenem has been suggested. Multiple drug-resistant K. pneumoniae...
used in combination with clavulanic acid under the designation Timentin), amikacin sulfate, penicillin, and gentamicin are commonly used. The latter - gentamicin...
of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains". Annals of Clinical...
Blaschke T, Sandhaus RA (Sep 1999). "Phase I Pharmacokinetics of Liposomal Amikacin (MiKasome) in Human Subjects: Dose Dependence and Urinary Clearance". Abstr...
hearing loss that might have been related to treatment with the antibiotic amikacin although the researchers believed the more likely cause was slight differences...
originally isolated from the sputum of a human patient. It is susceptible to amikacin, clarithromycin, and rifampin. Kim BJ, Hong SH, Yu HK, Park YG, Jeong J...
or ciprofloxacin. Aminoglycosides such as tobramycin, gentamicin, and amikacin are other choices for therapy.[citation needed] This ability to thrive...
usually substituted when a sulfa cannot be given; high-dose imipenem and amikacin have also been used in severe or refractory cases. Linezolid appears to...
serious side-effects; for example, antibiotics like aminoglycosides (such as amikacin, gentamicin, kanamycin, streptomycin, etc.) used for the treatment of drug-resistant...
piperacillin-tazobactam has produced results showing an increase in their affinity with amikacin and gentamicin in vitro, enabling the process of simultaneous Y-site infusion...
coverage: e.g., cefepime, ceftazidime, or an aminoglycoside: i.e. gentamicin, amikacin). The prognosis for ARS is dependent on the exposure dose, with anything...
carbenicillin, erythromycin, amikacin, chloramphenicol, and norfloxacin), L. fermentum was found to only be resistant to amikacin and norfloxacin.[citation...
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