Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, migraines or surgery.[9] It is also effective for treating gastroenteritis.[10][11] It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously (injection into a vein).[9]
Common side effects include diarrhea, constipation, headache, sleepiness, and itchiness.[9] Serious side effects include QT prolongation and severe allergic reaction.[9] It appears to be safe during pregnancy but has not been well studied in this group.[9] It is a serotonin 5-HT3 receptor antagonist.[9] It does not have any effect on dopamine receptors or muscarinic acetylcholine receptors.[12]
Ondansetron was patented in 1984 and approved for medical use in 1990.[13] It is on the World Health Organization's List of Essential Medicines.[14] It is available as a generic medication.[9] In 2021, it was the 79th most commonly prescribed medication in the United States, with more than 8million prescriptions.[15][16]
^"Atossa". MedicinesFAQ. 2022. Archived from the original on 28 August 2022. Retrieved 28 August 2022.
^Cite error: The named reference Ondansetron international was invoked but never defined (see the help page).
^"Ondansetron Use During Pregnancy". Drugs.com. 3 October 2019. Archived from the original on 18 September 2020. Retrieved 7 September 2020.
^"Zofran Product and Consumer Medicine Information Licence". TGA eBS. Archived from the original on 29 August 2022. Retrieved 28 August 2022.
^"Zofran Product information". Health Canada. 25 April 2012. Archived from the original on 29 August 2022. Retrieved 28 August 2022.
^"Zofran Tablets 4 mg - Summary of Product Characteristics (SmPC)". (emc). 19 January 2022. Archived from the original on 29 August 2022. Retrieved 28 August 2022.
^Cite error: The named reference Zofran FDA label was invoked but never defined (see the help page).
^"List of nationally authorised medicinal products : Active substance: ondansetron :Procedure no.: PSUSA/00002217/202102" (PDF). Ema.europa.eu. Retrieved 5 March 2022.
^ abcdefg"Ondansetron Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 3 May 2016. Retrieved 11 February 2017.
^Schnadower D, Finkelstein Y, Freedman SB (January 2015). "Ondansetron and probiotics in the management of pediatric acute gastroenteritis in developed countries". Current Opinion in Gastroenterology. 31 (1): 1–6. doi:10.1097/mog.0000000000000132. PMID 25333367. S2CID 9334264.
^Freedman SB, Ali S, Oleszczuk M, Gouin S, Hartling L (July 2013). "Treatment of acute gastroenteritis in children: an overview of systematic reviews of interventions commonly used in developed countries". Evidence-Based Child Health. 8 (4): 1123–37. doi:10.1002/ebch.1932. PMID 23877938.
^Miloro M, ed. (2012). Peterson's principles of oral and maxillofacial surgery (3rd ed.). Shelton, CT: People's Medical Pub. House-USA. p. 86. ISBN 978-1-60795-111-7. Archived from the original on 1 February 2016.
^FischerJ, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 448. ISBN 9783527607495. Archived from the original on 12 January 2023. Retrieved 25 August 2020.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Ondansetron - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation...
daily dose group. In a randomized, double-blind comparison of ondansetron versus ondansetron plus metopimazine as an antiemetic prophylaxis during platinum-based...
(Kytril), or in a single transdermal patch to the upper arm (SANCUSO). Ondansetron (Zofran) is administered in an oral tablet form, orally dissolving tablet...
use of ondansetron might possibly be linked to an increased rate of return to hospital in children. The intravenous preparation of ondansetron may be...
postoperative nausea and vomiting (PONV). It may be used together with ondansetron and dexamethasone. It is taken by mouth or administered by intravenous...
Administration to sell a generic version of Azithromycin, Citalopram, and Ondansetron. In October 2006, Barr Pharmaceuticals acquired Pliva. On December 23...
pyridoxine or metoclopramide are preferred. Prochlorperazine, dimenhydrinate, ondansetron (sold under the brand-name Zofran) or corticosteroids may be used if...
acetylcholine Acetylcholinesterase inhibitors Serotonin antagonists, such as ondansetron (an anti-emetic) known by its brand name Zofran Some cancer chemotherapy...
low as 0.625 mg. For treatment of nausea and vomiting, droperidol and ondansetron are equally effective; droperidol is more effective than metoclopramide...
chemotherapy-induced nausea and vomiting and appears to work about the same as ondansetron. The most common side-effects of chemotherapy treatment are nausea, vomiting...
antiemetics in the US are promethazine, metoclopramide, and the newer ondansetron. The word nausea is from Latin nausea, from Greek ναυσία – nausia, "ναυτία"...
to prevent PONV include medications such as antiemetics (for example, ondansetron or dexamethasone) or other drugs including tropisetron, dolasetron, cyclizine...
increase the antiemetic effect of 5-HT3 receptor antagonists, such as ondansetron. The exact mechanism of this interaction is not well-defined, but it...
prophylactic antiemetics (ondansetron, granisetron, etc.) in combination with corticosteroids. Aprepitant combined with ondansetron and dexamethasone has...
dehydrated. For a number of patients, potent anti-emetic drugs such as ondansetron (Zofran) or granisetron (Kytril), and dronabinol (Marinol) may be helpful...
category "A" prescription treatment for nausea and vomiting of pregnancy. Ondansetron may be beneficial, but there are some concerns regarding an association...
or no residue. Nitroglycerine tablets are an example, the anti-emetic ondansetron is another. Sublingual strips—similar to tablets in that they easily...
"Introduction". In Lobo M (ed.). Anti-emetics - Metoclopramide, Domperidone, Ondansetron, Cyclizine. Archived from the original on 2 April 2015. Retrieved 9 March...
such as St. John's wort. Concurrent use of 5-HT3 antagonists such as ondansetron, dolasetron, and palonosetron may reduce the effectiveness of both drugs...
vomiting. They include, but are not limited to: Dolasetron Granisetron Ondansetron Palonosetron Tropisetron Other 5-HT3 antagonists have been considered...
injections (antiemetics) such as maropitant, metoclopramide, dolasetron, ondansetron and prochlorperazine, and broad-spectrum antibiotic injections such as...
alcohol-induced psychosis and Zoldan et al. reported moderately successful use of ondansetron, a 5-HT3 receptor antagonist, in the treatment of levodopa psychosis...
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