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Oocyte activation information


Oocyte (or ovum/egg) activation is a series of processes that occur in the oocyte during fertilization.

Sperm entry causes calcium release into the oocyte. In mammals, this is caused by the introduction of phospholipase C isoform zeta (PLCζ) from the sperm cytoplasm.[1] Activation of the ovum includes the following events:

  • Cortical reaction to block against other sperm cells
  • Activation of egg metabolism
  • Reactivation of meiosis
  • DNA synthesis
  1. ^ Saleh A, Kashir J, Thanassoulas A, Safieh-Garabedian B, Lai FA, Nomikos M (2020). "Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update". Front. Cell Dev. Biol. 8 (28). doi:10.3389/fcell.2020.00028. PMC 7000359.

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Oocyte activation

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Oocyte (or ovum/egg) activation is a series of processes that occur in the oocyte during fertilization. Sperm entry causes calcium release into the oocyte...

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Oocyte

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An oocyte (UK: /ˈoʊəsaɪt/, US: /ˈoʊoʊ-/), oöcyte, or ovocyte is a female gametocyte or germ cell involved in reproduction. In other words, it is an immature...

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Biochemical cascade

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KIT in the oocyte, leading to the activation of PI3K/Akt pathway, allowing oocyte survival and development. During embryogenesis, oocytes initiate meiosis...

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Oogenesis

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Oocyte —(Meiosis I)—> First Polar body (Discarded afterward) + Secondary oocyte —(Meiosis II)—> Second Polar Body (Discarded afterward) + Ovum Oocyte...

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Globozoospermia

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has been found that treating globozoospermia with ICSI along with oocyte activation by calcium ionophore (an ion carrier used to increase intracellular...

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Ovarian follicle activation

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[citation needed] Another molecule that has been implicated in the activation of oocyte follicles is Forkhead boxL2 (Foxl2). In knock out studies, it has...

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Teratospermia

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intracytoplasmic sperm injection with globozoospermic sperm and electrical oocyte activation". Fertil. Steril. 92 (6): 2037.e5–2037.e9. doi:10.1016/j.fertnstert...

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Spermatozoon

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contributes with DNA/chromatin, a centriole, and perhaps also an oocyte-activating factor (OAF). It may also contribute with paternal messenger RNA (mRNA)...

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Nuclear transfer

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nuclear membrane is dissolved. Chemicals are also used to stimulate oocyte activation. When applied the membrane is completely dissolved. Somatic Cell Nuclear...

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Intracytoplasmic sperm injection

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that of ICSI, since additional stimuli are needed to ensure proper oocyte activation after spermatid injection. If all requirements for round spermatid...

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Parthenogenesis

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MII-arrested oocyte to proceed through meiosis. To initiate parthenogenesis of swine oocytes, various methods exist to induce an artificial activation that mimics...

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Vitellogenesis

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Vitellogenesis is the process of yolk protein formation in the oocytes during sexual maturation. The term vitellogenesis comes from the Latin vitellus...

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In vitro maturation

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is the technique of letting the contents of ovarian follicles and the oocytes inside mature in vitro. It can be offered to women with infertility problems...

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Knockout rat

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Fraichard A, Cozzi J: Generation of fertile cloned rats by regulating oocyte activation. Science 2003, 302:1179. Justice MJ, Noveroske JK, Weber JS, Zheng...

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Genetically modified mammal

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Cozzi, J (2003). "Generation of fertile cloned rats by regulating oocyte activation" (PDF). Science. 302 (5648): 1179. doi:10.1126/science.1088313. PMID 14512506...

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Dmitri Dozortsev

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Rybouchkin, Petra De Sutter, C. Qian, M. Dhont have discovered that oocyte activation during ICSI is triggered by a water-soluble, heat-sensitive, non species...

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Folliculogenesis

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follicle, a densely packed shell of somatic cells that contains an immature oocyte. Folliculogenesis describes the progression of a number of small primordial...

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Cortical granule

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secretory organelles (ranging from 0.2 um to 0.6 um in diameter) found within oocytes and are most associated with polyspermy prevention after the event of fertilization...

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Luteal phase

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to begin the menstrual cycle again. After ovulation and release of the oocyte, the anterior pituitary hormones–follicle-stimulating hormone (FSH) and...

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A23187

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Ionophore will replace absence of sperm acrosome, and plays role in oocyte activation after ICSI. Recommended use is 0.5 microgram/ml twice for 10 min interrupted...

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Maturation promoting factor

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stimulated with progesterone. Because the entry of oocytes into meiosis is frequently referred to as oocyte maturation, this cytoplasmic factor was called...

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Polyspermy

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concentrations. When the first spermatozoa get inside the oocyte, it brings in PLC-zeta, that is activated by oocyte's basal calcium concentrations, initiates the formation...

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Sperm chemotaxis

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concentration gradient of a chemoattractant secreted from the oocyte and thereby reach the oocyte. Since the discovery of sperm attraction to the female gametes...

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Resumption of meiosis

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Resumption of meiosis occurs as a part of oocyte meiosis after meiotic arrest has occurred. In females, meiosis of an oocyte begins during embryogenesis and will...

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Vitelline envelope

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during egg-laying. Before egg activation, the vitelline membrane is permeable to water, ions, and small molecules. Egg activation is stimulated by mechanical...

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Brian Dale

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soluble sperm factor in spermatozoa that is responsible for the activation of oocytes. His studies span animals and humans, from the identification of...

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Capacitation

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activation, involving the acrosome reaction. Non-mammalian spermatozoa do not require this capacitation step and are ready to fertilize an oocyte immediately...

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Dictyate

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not translated during dictyate. Shortly before ovulation, the oocyte of interest activates these mRNA strains. Translation of mRNA in dictyate is partly...

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