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Nuclear transfer information


BTX ECM 2001 Electrofusion generator used for nuclear transfer applications

Nuclear transfer is a form of cloning. The step involves removing the DNA from an oocyte (unfertilised egg), and injecting the nucleus which contains the DNA to be cloned. In rare instances, the newly constructed cell will divide normally, replicating the new DNA while remaining in a pluripotent state. If the cloned cells are placed in the uterus of a female mammal, a cloned organism develops to term in rare instances. This is how Dolly the Sheep and many other species were cloned. Cows are commonly cloned to select those that have the best milk production. On 24 January 2018, two monkey clones were reported to have been created with the technique for the first time.[1][2][3]

Despite this, the low efficiency of the technique has prompted some researchers, notably Ian Wilmut, creator of Dolly the cloned sheep, to abandon it.[4]

  1. ^ Liu, Zhen; et al. (24 January 2018). "Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer". Cell. 172 (4): 881–887.e7. doi:10.1016/j.cell.2018.01.020. PMID 29395327.
  2. ^ Briggs, Helen (24 January 2018). "First monkey clones created in Chinese laboratory". BBC News. Retrieved 24 January 2018.
  3. ^ "Scientists Successfully Clone Monkeys; Are Humans Up Next?". The New York Times. Associated Press. 24 January 2018. Retrieved 24 January 2018.
  4. ^ Roger Highfield Dolly creator Prof Ian Wilmut shuns cloning. The Telegraph. 16 November 2007

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Nuclear transfer

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Somatic cell nuclear transfer

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In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory strategy for creating a viable embryo from a body cell and...

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Altered nuclear transfer is an alternative method of obtaining embryonic-like, pluripotent stem cells without the creation and destruction of human embryos...

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Human cloning

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of therapeutic cloning that are being researched are somatic-cell nuclear transfer and (more recently) pluripotent stem cell induction. Reproductive cloning...

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John Gurdon

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1337135100. PMC 166179. PMID 12821779. Gurdon, J. B. (2006). "From Nuclear Transfer to Nuclear Reprogramming: The Reversal of Cell Differentiation". Annual...

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detonation of nuclear weapons. Five are considered to be nuclear-weapon states (NWS) under the terms of the Treaty on the Non-Proliferation of Nuclear Weapons...

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Cloning

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known as reproductive cloning, is often accomplished via somatic-cell nuclear transfer (SCNT), a cloning method in which a viable embryo is created from a...

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Zhong Zhong and Hua Hua

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referred to as cynomolgus monkeys) that were created through somatic cell nuclear transfer (SCNT), the same cloning technique that produced Dolly the sheep in...

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Somatic cell

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animal to be produced. One method of doing this is called "somatic cell nuclear transfer" and involves removing the nucleus from a somatic cell, usually a skin...

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Mule

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[citation needed] On 5 May 2003, Idaho Gem, a mule foal cloned by nuclear transfer of cells from foetal material, was born at the University of Idaho...

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Christopher Reeve

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Human Cloning Prohibition Act of 2001, which would allow somatic cell nuclear transfer research, but would ban reproductive cloning. He argued stem cell implantation...

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Yamanaka was the first to demonstrate (in 2006) that this somatic cell nuclear transfer or oocyte-based reprogramming process (see below), that Gurdon discovered...

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the journal Science that they successfully developed a somatic cell nuclear transfer method with which they made the stem cells. In 2005, they published...

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Nuclear sharing is a concept in NATO's policy of nuclear deterrence, which allows member countries without nuclear weapons of their own to participate...

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Polly and Molly

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Edinburgh, Scotland. The creation of Polly and Molly built on the somatic nuclear transfer experiments that led to the cloning of Dolly the Sheep. The crucial...

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Embryo

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other ART techniques, including cloning via interspecies somatic cell nuclear transfer (iSCNT), are also used in attempts to increase the numbers of endangered...

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Embryonic stem cell

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from a patient and a donated egg through the process of somatic cell nuclear transfer. The inner cell mass (cells of interest), from the blastocyst stage...

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In nuclear physics and nuclear chemistry, a nuclear reaction is a process in which two nuclei, or a nucleus and an external subatomic particle, collide...

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such as the UK and China have promoted the research. Somatic cell nuclear transfer is a cloning method that can be used to create a cloned embryo for...

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List of animals that have been cloned

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Nuclear power is the use of nuclear reactions to produce electricity. Nuclear power can be obtained from nuclear fission, nuclear decay and nuclear fusion...

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creating a new stem cell line. This technique known as somatic cell nuclear transfer (SCNT) creates pluripotent cells that are genetically identical to...

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Treaty on the Prohibition of Nuclear Weapons

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stationing, transfer, use and threat of use of nuclear weapons, as well as assistance and encouragement to the prohibited activities. For nuclear-armed states...

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