Adenine phosphoribosyltransferase (APRTase) is an enzyme encoded by the APRT gene, found in humans on chromosome 16.[5] It is part of the Type I PRTase family and is involved in the nucleotide salvage pathway, which provides an alternative to nucleotide biosynthesis de novo in humans and most other animals.[6] In parasitic protozoa such as giardia, APRTase provides the sole mechanism by which AMP can be produced.[7] APRTase deficiency contributes to the formation of kidney stones (urolithiasis) and to potential kidney failure.[8]
The APRT gene is constituted by 5 exons (in blue). The start (ATG) and stop (TGA) codons are indicated (bold blue). CpG dinucleotides are emphasized in red. They are more abundant in the upstream region of the gene where they form a CpG island.
^ abcGRCh38: Ensembl release 89: ENSG00000198931 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000006589 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Valaperta R, Rizzo V, Lombardi F, Verdelli C, Piccoli M, Ghiroldi A, Creo P, Colombo A, Valisi M, Margiotta E, Panella R, Costa E (1 July 2014). "Adenine phosphoribosyltransferase (APRT) deficiency: identification of a novel nonsense mutation". BMC Nephrology. 15: 102. doi:10.1186/1471-2369-15-102. PMC 4094445. PMID 24986359.
^Cite error: The named reference Silva_2008 was invoked but never defined (see the help page).
^Sarver AE, Wang CC (Oct 2002). "The adenine phosphoribosyltransferase from Giardia lamblia has a unique reaction mechanism and unusual substrate binding properties". The Journal of Biological Chemistry. 277 (42): 39973–80. doi:10.1074/jbc.M205595200. PMID 12171924.
^Shi W, Tanaka KS, Crother TR, Taylor MW, Almo SC, Schramm VL (Sep 2001). "Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae". Biochemistry. 40 (36): 10800–9. doi:10.1021/bi010465h. PMID 11535055.
and 23 Related for: Adenine phosphoribosyltransferase information
Adeninephosphoribosyltransferase (APRTase) is an enzyme encoded by the APRT gene, found in humans on chromosome 16. It is part of the Type I PRTase family...
Adeninephosphoribosyltransferase deficiency is a rare autosomal recessive metabolic disorder caused by mutations of the APRT gene. Adenine phosphoribosyltransferase...
A phosphoribosyltransferase is a type of transferase enzyme. Types include: Adeninephosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase...
Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism. Found in all living cells, NAD is called a dinucleotide because it consists...
are two types of phosphoribosyltransferases: adeninephosphoribosyltransferase (APRT) and hypoxanthine-guanine phosphoribosyltransferase (HGPRT). HGPRT...
Thiemann, Otavio H. (2008). "Structural Complexes of Human AdeninePhosphoribosyltransferase Reveal Novel Features of the APRT Catalytic Mechanism". Journal...
amidotransferase; adeninephosphoribosyltransferase. It is also used to treat kidney stones caused by deficient activity of adeninephosphoribosyltransferase. Allopurinol...
Nicotinamide phosphoribosyltransferase (NAmPRTase or NAMPT), formerly known as pre-B-cell colony-enhancing factor 1 (PBEF1) or visfatin for its extracellular...
nucleotide salvage. For example, adenine + PRPP --> AMP + PPi. This reaction requires the enzyme adeninephosphoribosyltransferase. Free guanine is salvaged...
often produce stones composed of xanthine. People affected by adeninephosphoribosyltransferase deficiency may produce 2,8-dihydroxyadenine stones, alkaptonurics...
In enzymology, a xanthine phosphoribosyltransferase (EC 2.4.2.22) is an enzyme that catalyzes the chemical reaction XMP + diphosphate ⇌ {\displaystyle...
Urlaub, G; Chasin, L (1979). "DNA-mediated transfer of the adeninephosphoribosyltransferase locus into mammalian cells". Proceedings of the National Academy...
transfer of a pentose. Examples include: adeninephosphoribosyltransferase hypoxanthine-guanine phosphoribosyltransferase pertussis toxin poly ADP ribose polymerase...
APRT may refer to: Adeninephosphoribosyltransferase, an enzyme Adeninephosphoribosyltransferase deficiency, a genetic and metabolic disorder This disambiguation...
Transphosphoribosidase may refer to: Adeninephosphoribosyltransferase, an enzyme Hypoxanthine phosphoribosyltransferase This set index page lists enzyme...
Hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in nucleotide salvage. Hypoxanthine is also a spontaneous deamination product of adenine. Because...
consisting of one to three phosphates. The four nucleobases in DNA are guanine, adenine, cytosine, and thymine; in RNA, uracil is used in place of thymine. Nucleotides...
and a form of vitamin B3. It functions as a precursor to nicotinamide adenine dinucleotide, or NAD+, through a two-step and a three-step pathway. While...
phosphotransacetylase, adenylosuccinate synthase, adeninephosphoribosyltransferases, and guanine phosphoribosyltransferases. The human subjects experienced increases...
661–671. A Saccharomyces cerevisiae gene encoding a potential adeninephosphoribosyltransferase Yuryev A, and Corden JL. Yeast 1994;10 (5): 659–662. Determination...
the nucleic acid RNA. The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil...
nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme responsible for the transformation of nicotinamide into nicotinamide adenine dinucleotide...
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