The image above contains clickable linksInteractive image of nucleic acid structure (primary, secondary, tertiary, and quaternary) using DNA helices and examples from the VS ribozyme and telomerase and nucleosome. (PDB: ADNA, 1BNA, 4OCB, 4R4V, 1YMO, 1EQZ)DNA coils and winds around histone proteins to condense into chromatin.
Nucleic acidquaternary structure refers to the interactions between separate nucleic acid molecules, or between nucleic acid molecules and proteins. The concept is analogous to protein quaternary structure, but as the analogy is not perfect, the term is used to refer to a number of different concepts in nucleic acids and is less commonly encountered.[1] Similarly other biomolecules such as proteins, nucleic acids have four levels of structural arrangement: primary, secondary, tertiary, and quaternary structure. Primary structure is the linear sequence of nucleotides, secondary structure involves small local folding motifs, and tertiary structure is the 3D folded shape of nucleic acid molecule. In general, quaternary structure refers to 3D interactions between multiple subunits. In the case of nucleic acids, quaternary structure refers to interactions between multiple nucleic acid molecules or between nucleic acids and proteins. Nucleic acid quaternary structure is important for understanding DNA, RNA, and gene expression because quaternary structure can impact function. For example, when DNA is packed into heterochromatin, therefore exhibiting a type of quaternary structure, gene transcription will be inhibited.
^Jones CP, Ferré-D'Amaré AR (April 2015). "RNA quaternary structure and global symmetry". Trends in Biochemical Sciences. 40 (4): 211–20. doi:10.1016/j.tibs.2015.02.004. PMC 4380790. PMID 25778613.
and 28 Related for: Nucleic acid quaternary structure information
Nucleicacidstructure refers to the structure of nucleicacids such as DNA and RNA. Chemically speaking, DNA and RNA are very similar. Nucleicacid structure...
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the functions of an organism. Nucleicacids also have a secondary structure and tertiary structure. Primary structure is sometimes mistakenly referred...
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loops, bulges, and internal loops for nucleicacids. The terms primary, secondary, tertiary, and quaternarystructure were introduced by Kaj Ulrik Linderstrøm-Lang...
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and quaternarystructures given the protein's amino acid sequence and its cellular conditions. A list of software for protein tertiary structure prediction...
In biochemistry, the native state of a protein or nucleicacid is its properly folded and/or assembled form, which is operative and functional. The native...
Protein structure prediction is the inference of the three-dimensional structure of a protein from its amino acid sequence—that is, the prediction of...
prediction programs List of protein secondary structure prediction programs Comparison of nucleicacid simulation software List of software for molecular...
neutron diffraction structure determination of protein and nucleicacid components. III. The crystal and molecular structure of the amino acid α-glycine" (PDF)...
proteins and nucleicacids. The function of these molecules is determined by their shape as well as their composition, and their structure has multiple...
biochemistry deals with the structures, bonding, functions, and interactions of biological macromolecules such as proteins, nucleicacids, carbohydrates, and...
include large macromolecules such as proteins, carbohydrates, lipids, and nucleicacids, as well as small molecules such as vitamins and hormones. A more general...
7-methine structures with reactive groups on either one or both of the nitrogen ends so that they can be chemically linked to either nucleicacids or protein...
unstable. Like other biological macromolecules such as polysaccharides and nucleicacids, proteins are essential parts of organisms and participate in virtually...
biotechnology to separate biological macromolecules, usually proteins or nucleicacids, according to their electrophoretic mobility. Electrophoretic mobility...
tertiary, and quaternary levels of biomolecular structure are disrupted, leaving only the primary structure to be analyzed. Nucleicacids are often denatured...
carbohydrates, proteins, nucleicacids and lipids within the framework of the relation between their structure (see: nucleicacidstructure, carbohydrate chemistry...
amino acids in a protein that are twisted into a coil (a helix). The alpha helix is the most common structural arrangement in the secondary structure of...
linear chain of amino acids, changes from an unstable random coil into a more ordered three-dimensional structure. This structure permits the protein to...
proteins, nucleicacids and polymeric materials. Being bi-functional, glutaraldehyde is a crosslinker, which rigidifies macromolecular structures and shuts...
Boom method (aka Boom nucleicacid extraction method) is a solid phase extraction method for isolating nucleicacid from a biological sample. This method...
sensitive fluorescent stain of the SYBR family of dyes for the detection of nucleicacids. The SYBR family of dyes is produced by Molecular Probes Inc., now owned...
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