Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Glutaraldehyde is an organic compound with the formula (CH2)3(CHO)2. The molecule consists of a five carbon chain doubly terminated with formyl (CHO) groups. It is usually used as a solution in water, and such solutions exists as a collection of hydrates, cyclic derivatives, and condensation products, several of which interconvert. Because the molecule has two aldehyde functional groups, glutaraldehyde (and its hydrates) can crosslink substances with primary amine groups, through condensation. Crosslinking can rigidify and deactivate proteins and other molecules that are critical for normal biological function, such as DNA, and so glutaraldehyde solutions are effective biocides and fixatives. It is sold under the brandnames Cidex and Glutaral.[3][4][5][6] As a disinfectant, it is used to sterilize surgical instruments.[3]
^Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. p. 907. doi:10.1039/9781849733069-FP001. ISBN 978-0-85404-182-4.
^ abcd"CDC - NIOSH Pocket Guide to Chemical Hazards -Glutaraldehyde". www.cdc.gov. Archived from the original on 13 January 2017. Retrieved 11 January 2017.
^ abWorld Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 323, 325. hdl:10665/44053. ISBN 9789241547659.
^British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 825. ISBN 9780857111562.
^Bonewit-West, Kathy (2015). Clinical Procedures for Medical Assistants. Elsevier Health Sciences. p. 96. ISBN 9781455776610. Archived from the original on 6 October 2022. Retrieved 9 September 2017.
^Sullivan, John Burke; Krieger, Gary R. (2001). Clinical Environmental Health and Toxic Exposures. Lippincott Williams & Wilkins. p. 601. ISBN 9780683080278. Archived from the original on 10 October 2022. Retrieved 19 September 2020.
Glutaraldehyde is an organic compound with the formula (CH2)3(CHO)2. The molecule consists of a five carbon chain doubly terminated with formyl (CHO) groups...
small molecules in tissues requires the tissue to be glutaraldehyde-fixed, as the glutaraldehyde covalent-linkage on the molecule of interest often forms...
purpose. Typically, embalming fluid contains a mixture of formaldehyde, glutaraldehyde, methanol, and other solvents. The formaldehyde content generally ranges...
CIDEX is a brand name for a Glutaraldehyde-free (0.55% ortho-phthalaldehyde) high-level disinfecting solution used within the field of medicine. The CIDEX...
for proteins, but it is less widely used than the related dialdehyde glutaraldehyde. Succinaldehyde is generated by the oxidation of tetrahydrofuran with...
paraformaldehyde 25 ml distilled water 1M sodium hydroxide 2 to 4 drops 50% glutaraldehyde 5.0 ml 0.2M cacodylate buffer, pH 7.4, 20.0 ml Mix the paraformaldehyde...
Unsaturated members include maleic and fumaric acids and their esters. Glutaraldehyde (CH2)3(CHO)2 is the simplest and parent 1,5-dialdehyde. It hydrates...
saline). For electron microscopy, the most commonly used fixative is glutaraldehyde, usually as a 2.5% solution in phosphate buffered saline. Other fixatives...
needed] Some bacteria have developed resistance to glutaraldehyde, and it has been found that glutaraldehyde can cause asthma and other health hazards, hence...
by incubation in a solution of a buffered chemical fixative, such as glutaraldehyde, sometimes in combination with formaldehyde and other fixatives, and...
dusts, spraying of isocyanate paint in vehicle repair, formaldehyde, glutaraldehyde, anhydrides, glues, dyes, metal working fluids, oil mists, molds. Smoking...
(1995). "Comparison of the mycobactericidal activity of 2% alkaline glutaraldehyde and 'Nu-Cidex' (0.35% peracetic acid)". J. Hosp. Infect. 30 (3): 237–240...
period. Vinyl gloves show poor resistance to many chemicals, including glutaraldehyde-based products and alcohols used in formulation of disinfectants for...
5-3.5. PIPES has been documented minimizing lipid loss when buffering glutaraldehyde histology in plant and animal tissues. Fungal zoospore fixation for...
potassium carbonates—used for maintaining effectiveness of crosslinkers. Glutaraldehyde- a biocide that prevents pipe corrosion from microbial activity. Guar...
with LD50 i.v. 382 mg/kg in mice, therefore, much less toxic than glutaraldehyde and many other commonly used synthetic cross-linking reagents. Furthermore...
by manufacturer Heraeus Kulzer, a German company. Its formula of 5% glutaraldehyde and 35% HEMA (hydroxy-ethyl methacrylate) in water is used to help control...
It is the first virus ever shown to be resistant to inactivation by glutaraldehyde, which is among the most common strong disinfectants used in hospitals...
common disinfectants. Exposure to 90% ethanol for at least 1 minute, 2% glutaraldehyde,[citation needed] 30% Savlon, and/or 1% sodium hypochlorite can disinfect...
H. N. (1972). "The Hydration and Polymerisation of Succinaldehyde, Glutaraldehyde, and Adipaldehyde". Journal of the Chemical Society, Perkin Transactions...
indefinitely. Typical embalming fluid contains a mixture of formaldehyde, glutaraldehyde, methanol, humectants and wetting agents, and other solvents that can...
bromide), and organic azide (via click chemistry or non-specifically (glutaraldehyde)). Additionally, various functional groups can be present to alter their...
Retinaldehyde Glycolaldehyde Glyoxal Malondialdehyde Succindialdehyde Glutaraldehyde Phthalaldehyde Of all aldehydes, formaldehyde is produced on the largest...
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