Nicotinate riboside kinase (EC 2.7.1.173, ribosylnicotinic acid kinase, nicotinic acid riboside kinase, NRK1) is an enzyme with systematic name ATP:beta-D-ribosylnicotinate 5-phosphotransferase.[1] This enzyme catalyses the following chemical reaction
ATP + beta-D-ribosylnicotinate ADP + nicotinate beta-D-ribonucleotide
The enzyme from yeast and human also acts as EC 2.7.1.22 (ribosylnicotinamide kinase).
^Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C (October 2007). "Nicotinamide riboside kinase structures reveal new pathways to NAD+". PLOS Biology. 5 (10): e263. doi:10.1371/journal.pbio.0050263. PMC 1994991. PMID 17914902.
and 6 Related for: Nicotinate riboside kinase information
In 2004, Charles Brenner and co-workers uncovered the nicotinamide ribosidekinase pathway to NAD+. The non-redox roles of NAD(P) were discovered later...
containing ribosylnicotinamide kinase. Bieganowski, Pawel & Brenner, Charles. (2004). Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK...
niacin (nicotinic acid), nicotinamide (niacinamide), and nicotinamide riboside. All three forms of vitamin B3 are converted within the body to nicotinamide...
in 3 metabolic pathways: purine metabolism, pyrimidine metabolism, and nicotinate and nicotinamide metabolism. Purine nucleoside phosphorylase is an enzyme...
Fletcher RS, Lavery GG (2018). "The emergence of the nicotinamide ribosidekinases in the regulation of NAD+ metabolism". Journal of Molecular Endocrinology...
Global Information