crystal structure analysis of deamino-oxytocin. This image shows conformational flexibility and receptor binding of the hormone to oxytocin receptors
Identifiers
Symbol
Hormone_4
Pfam
PF00220
InterPro
IPR022423
PROSITE
PDOC00237
SCOP2
1xy1 / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Neurohypophysial hormones, C-terminal Domain
solution structure of the monomeric form of a mutant unliganded bovine neurophysin, minimized average structure
Identifiers
Symbol
Hormone_5
Pfam
PF00184
InterPro
IPR000981
PROSITE
PDOC00237
SCOP2
1xy2 / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The neurohypophysial hormones form a family of structurally and functionally related peptide hormones. Their representatives in humans are oxytocin and vasopressin. They are named after the location of their release into the blood, the neurohypophysis (another name for the posterior pituitary).
Most of the circulating oxytocin and vasopressin hormones are synthesized in magnocellular neurosecretory cells of the supraoptic nucleus and paraventricular nucleus of the hypothalamus. They are then transported in neurosecretory granules along axons within the hypothalamo-neurohypophysial tract by axoplasmic flow to axon terminals forming the pars nervosa of the posterior pituitary. There, they are stored in Herring bodies and can be released into the circulation on the basis of hormonal and synaptic signals with assistance from pituicytes.[1][2][3]
Oxytocin mediates contraction of the smooth muscle of the uterus and mammary gland, while vasopressin has antidiuretic action on the kidney, and mediates vasoconstriction of the peripheral vessels.[4] Due to the similarity of the two hormones, there is cross-reaction: oxytocin has a slight antidiuretic function, and high levels of AVP can cause uterine contractions.[5][6] In common with most active peptides, both hormones are synthesised as larger protein precursors that are enzymatically converted to their mature forms.
Members of this family are found in birds, fish, reptiles and amphibians (mesotocin, isotocin, valitocin, glumitocin, aspargtocin, vasotocin, seritocin, asvatocin, phasvatocin), in worms (annetocin, nematocin), octopuses (cephalotocin, octopressin), insects (locupressin, inotocin) and in molluscs (conopressins G and S).[7] Animals that lack a hormone from this family include fruit flies, and at least some mosquitos, silkworms, and honeybees.[8]
^Burbach JP, Luckman SM, Murphy D, Gainer H (July 2001). "Gene regulation in the magnocellular hypothalamo-neurohypophysial system". Physiol. Rev. 81 (3): 1197–267. doi:10.1152/physrev.2001.81.3.1197. PMID 11427695.
^Jones CW, Pickering BT (December 1972). "Intra-axonal transport and turnover of neurohypophysial hormones in the rat". J. Physiol. 227 (2): 553–64. doi:10.1113/jphysiol.1972.sp010047. PMC 1331210. PMID 4678722.
^Hatton GI (September 1988). "Pituicytes, glia and control of terminal secretion" (PDF). J. Exp. Biol. 139: 67–79. doi:10.1242/jeb.139.1.67. PMID 3062122.
^Acher R, Chauvet J (1988). "Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors". Biochimie. 70 (9): 1197–1207. doi:10.1016/0300-9084(88)90185-X. PMID 3147712.
^Li C, Wang W, Summer SN, Westfall TD, Brooks DP, Falk S, Schrier RW (February 2008). "Molecular mechanisms of antidiuretic effect of oxytocin". J. Am. Soc. Nephrol. 19 (2): 225–32. doi:10.1681/ASN.2007010029. PMC 2396735. PMID 18057218.
^Joo KW, Jeon US, Kim GH, Park J, Oh YK, Kim YS, Ahn C, Kim S, Kim SY, Lee JS, Han JS (October 2004). "Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2". Nephrol. Dial. Transplant. 19 (10): 2480–6. doi:10.1093/ndt/gfh413. PMID 15280526.
^Michel G, Acher R, Chauvet J, Ouedraogo Y, Chou J, Chait BT (1995). "A new neurohypophysial peptide, seritocin ([Ser5,Ile8]-oxytocin), identified in a dryness-resistant African toad, Bufo regularis". Int. J. Pept. Protein Res. 45 (5): 482–487. doi:10.1111/j.1399-3011.1995.tb01064.x. PMID 7591488.
^"40D". Handbook of Hormones. 2016. doi:10.1016/B978-0-12-801028-0.00203-8.
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