The oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin.[4][5] In humans, the oxytocin receptor is encoded by the OXTR gene[6][7] which has been localized to human chromosome 3p25.[8]
Evolutionary tree of the oxytocin, vasotocin, mesotocin and isotocin receptors and their ligands. From Koechbach et al.[9]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000049112 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gimpl G, Fahrenholz F (April 2001). "The oxytocin receptor system: structure, function, and regulation". Physiological Reviews. 81 (2): 629–83. doi:10.1152/physrev.2001.81.2.629. PMID 11274341. S2CID 13265083.
^Zingg HH, Laporte SA (July 2003). "The oxytocin receptor". Trends in Endocrinology and Metabolism. 14 (5): 222–7. doi:10.1016/S1043-2760(03)00080-8. PMID 12826328. S2CID 21540056.
^EntrezGene 5021
^Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H (April 1992). "Structure and expression of a human oxytocin receptor" (PDF). Nature. 356 (6369): 526–9. Bibcode:1992Natur.356..526K. doi:10.1038/356526a0. PMID 1313946. S2CID 4273722. Archived from the original (PDF) on 2017-09-21. Retrieved 2021-05-29.
^Simmons CF, Clancy TE, Quan R, Knoll JH (April 1995). "The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids". Genomics. 26 (3): 623–5. doi:10.1016/0888-7543(95)80188-R. PMID 7607693.
^Koehbach J, Stockner T, Bergmayr C, Muttenthaler M, Gruber CW (February 2013). "Insights into the molecular evolution of oxytocin receptor ligand binding". Biochemical Society Transactions. 41 (1): 197–204. doi:10.1042/BST20120256. PMC 3634130. PMID 23356283.
The oxytocinreceptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin. In humans, the oxytocin...
structure where oxytocinreceptors are expressed. The endocrine effects of hormonal oxytocin and the cognitive or behavioral effects of oxytocin neuropeptides...
An oxytocinreceptor agonist is a compound that acts as an agonist of the oxytocinreceptor. Examples include peptide oxytocinreceptor agonists like oxytocin...
Carbetocin is a manufactured long acting form of oxytocin. It works by activating the oxytocinreceptor which causes the uterus to contract. Carbetocin...
stemming from the oxytocinreceptor (OXTR), the binding and activation site of oxytocin. When oxytocin binds to its associated receptors in the uterus, a...
personality disorder, and certain other personality disorders. Oxytocinreceptor agonists, like oxytocin and LIT-001, are of theoretical interest in the potential...
of oxytocinreceptor antagonist had lower social recognition scores than rats that received a vehicle injection, and microinjections of oxytocin into...
nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocinreceptor antagonist (VOTra). Atosiban inhibits the oxytocin-mediated release...
org/10.1016/0014-5793(84)80304-X "Vasopressin and OxytocinReceptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and...
channel blockers, oxytocinreceptor antagonists and combinations of tocolytics. Calcium-channel blockers (such as nifedipine) and oxytocin antagonists (such...
"Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocinreceptor activation". Psychopharmacology...
hormone receptor is a receptor molecule that binds to a specific hormone. Hormone receptors are a wide family of proteins made up of receptors for thyroid...
420-amino-acid sequence of the AVPR1B receptor shared the most overall similarities with the AVP1A, AVP2 and oxytocinreceptors. AVPR1B maps to chromosome region...
elevated level of estrogen stimulates prostaglandin secretion and oxytocinreceptor development.) Exposure of fetuses to cortisol during gestation can...
at term, promote cervical softening and expression of myometrial oxytocinreceptors.[citation needed] In baboons, blocking of estrogen production leads...
an orally bioavailable drug which acts as a selective and potent oxytocinreceptor antagonist (Ki = 0.13 nM). It was initially developed by GlaxoSmithKline...
maintenance of uterus function during gestation period, also upregulates oxytocinreceptor in myometrium Ovulation Surge in estrogen level induces the release...
Retosiban also known as GSK-221,149-A is an oral drug which acts as an oxytocinreceptor antagonist. It is being developed by GlaxoSmithKline for the treatment...
temporary changes in oxytocin levels, the influence of oxytocin on empathic responses may also be influenced by an oxytocinreceptor gene polymorphism,...
F2α, which both abolishes the progesterone block, and lowers the oxytocinreceptor threshold; and increases expression of relaxin, stretching the pelvic...
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