dentate gyrus of hippocampal formation granule cell
primary visual cortex
CA3 field
lateral geniculate nucleus
Region I of hippocampus proper
medial dorsal nucleus
perirhinal cortex
superior frontal gyrus
entorhinal cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
hormone activity
protein binding
neuropeptide hormone activity
peptide hormone receptor binding
Cellular component
perikaryon
extracellular region
terminal bouton
neuronal cell body
dendrite
axon hillock
axon initial segment
extracellular space
axon
Biological process
regulation of sensory perception of pain
eating behavior
behavioral fear response
negative regulation of appetite
protein kinase C-activating G protein-coupled receptor signaling pathway
positive regulation of mitochondrial depolarization
positive regulation of glutamate secretion
positive regulation of cell population proliferation
positive regulation of protein oligomerization
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
release of cytochrome c from mitochondria
apoptotic process
neuron migration
axonogenesis
regulation of signaling receptor activity
G protein-coupled receptor signaling pathway
memory
visual learning
negative regulation of eating behavior
positive regulation of sensory perception of pain
negative regulation of behavioral fear response
positive regulation of behavioral fear response
digestion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
885
12424
Ensembl
ENSG00000187094
ENSMUSG00000032532
UniProt
P06307
P09240
RefSeq (mRNA)
NM_000729 NM_001174138
NM_031161 NM_001284508
RefSeq (protein)
NP_000720 NP_001167609
NP_001271437 NP_112438
Location (UCSC)
Chr 3: 42.26 – 42.27 Mb
Chr 9: 121.32 – 121.32 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cholecystokinin (CCK or CCK-PZ; from Greek chole, "bile"; cysto, "sac"; kinin, "move"; hence, move the bile-sac (gallbladder)) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin, formerly called pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum, the first segment of the small intestine. Its presence causes the release of digestive enzymes and bile from the pancreas and gallbladder, respectively, and also acts as a hunger suppressant.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000187094 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032532 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Johnson LR (2013). Gastrointestinal Physiology (Eighth ed.). Philadelphia: Elsevier/Mosby. ISBN 978-0-323-10085-4.
^Bowen R (28 January 2001). "Cholecystokinin". Colorado State University. Archived from the original on 17 March 2016. Retrieved 6 November 2015.
Cholecystokinin (CCK or CCK-PZ; from Greek chole, "bile"; cysto, "sac"; kinin, "move"; hence, move the bile-sac (gallbladder)) is a peptide hormone of...
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin...
The cholecystokinin B receptor also known as CCKBR or CCK2 is a protein that in humans is encoded by the CCKBR gene. This gene encodes a G protein-coupled...
The Cholecystokinin A receptor is a human protein, also known as CCKAR or CCK1, with CCK1 now being the IUPHAR-recommended name. This gene encodes a G-protein...
mediators of the gastrocolic reflex. These include serotonin, neurotensin, cholecystokinin, prostaglandin E1, and gastrin. Clinically, the gastrocolic reflex...
breaking down proteins, fat, and DNA/RNA. Acinar cells are stimulated by cholecystokinin (CCK), which is a hormone/neurotransmitter produced by the intestinal...
Later studies showed that most of the gut peptides, such as secretin, cholecystokinin or substance P, were found to play a role of neurotransmitters and...
cholecystokinin receptor antagonist is a specific type of receptor antagonist which blocks the receptor sites for the peptide hormone cholecystokinin...
digestive process. These digestive hormones, including gastrin, secretin, cholecystokinin, and ghrelin, are mediated through either intracrine or autocrine mechanisms...
duodenum. Secretion is influenced by hormones including secretin, cholecystokinin, and VIP, as well as acetylcholine stimulation from the vagus nerve...
of the gallbladder. The sphincter of Oddi is relaxed by the hormone cholecystokinin via vasoactive intestinal peptide. Pancreatitis can result from a failure...
the gastrin/cholecystokinin family) of proteins is defined by the peptide hormones gastrin and cholecystokinin. Gastrin and cholecystokinin (CCK) are structurally...
secretion. It is the antagonist of cholecystokinin and opposes pancreatic secretion stimulated by cholecystokinin. It may stimulate the migrating motor...
juice secretion is principally regulated by the hormones secretin and cholecystokinin, which are produced by the walls of the duodenum, and by the action...
to increase weight loss and treat obesity through GLP-1 agonists. Cholecystokinin (CCK) is gut peptide produced by the duodenum in response to fat and...
weight loss drug orlistat is known to increase the risk of gallstones. Cholecystokinin deficiency caused by celiac disease increases risk of gallstone formation...
acetylcholine (ACh) as its neurotransmitter, although peptides (such as cholecystokinin) can be used. The ACh acts on two types of receptors, the muscarinic...
antrum of the stomach, duodenum, and the pancreas. Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like...
gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used...
the gallbladder enter the small intestine in response to the hormone cholecystokinin, which is produced in the response to the presence of nutrients. Secretin...
gallbladder and pancreas. It is the 8-amino acid C-terminal fragment of cholecystokinin, and also known as CCK-8. Common adverse effects following administration...
research purposes, by administering a bolus injection of the neuropeptide cholecystokinin-tetrapeptide (CCK-4). Various animal models of panic attacks have been...
stimulates the secretion of cholecystokinin (CCK) from I cells of the duodenum and jejunum. In response to cholecystokinin, the gallbladder rhythmically...
Global Information
