Neuropeptide Y receptor Y5 information

NPY5R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HE6
Identifiers
Aliases	NPY5R, NPY5-R, NPYR5, NPYY5-R, Neuropeptide Y receptor Y5
External IDs	OMIM: 602001; MGI: 108082; HomoloGene: 21241; GeneCards: NPY5R; OMA:NPY5R - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	163,351,934 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	67,140,780 bp
RNA expression pattern
	Top expressed in
	testicle; ; adipose tissue; ; tibial arteries; ; spleen; ; subcutaneous adipose tissue; ; Descending thoracic aorta; ; prefrontal cortex; ; right adrenal cortex; ; left adrenal cortex; ; abdominal fat;
	Top expressed in
	lumbar subsegment of spinal cord; ; suprachiasmatic nucleus; ; substantia nigra; ; embryo; ; Region I of hippocampus proper; ; neuron; ; dentate gyrus of hippocampal formation granule cell; ; facial motor nucleus; ; nucleus accumbens; ; arcuate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neuropeptide Y receptor activity; G protein-coupled receptor activity; signal transducer activity; peptide YY receptor activity; pancreatic polypeptide receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; neuron projection;
Biological process	G protein-coupled receptor signaling pathway; negative regulation of glutamate secretion; eating behavior; outflow tract morphogenesis; negative regulation of apoptotic process; cardiac left ventricle morphogenesis; negative regulation of synaptic transmission, GABAergic; feeding behavior; positive regulation of acute inflammatory response; generation of ovulation cycle rhythm; neuropeptide signaling pathway; signal transduction; positive regulation of smooth muscle cell proliferation; positive regulation of cell population proliferation; human ageing; chemical synaptic transmission; negative regulation of acute inflammatory response to antigenic stimulus; positive regulation of ERK1 and ERK2 cascade; blood circulation;
	Sources:Amigo / QuickGO
Orthologs
	4889
	18168
	ENSG00000164129
	ENSMUSG00000044014
	Q15761
	O70342
	NM_006174; NM_001317091; NM_001317092
	NM_016708; NM_001358957; NM_001358958
	NP_001304020; NP_001304021; NP_006165
	NP_057917; NP_001345886; NP_001345887
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164129 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044014 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL (Jul 1996). "A receptor subtype involved in neuropeptide-Y-induced food intake". Nature. 382 (6587): 168–71. Bibcode:1996Natur.382..168G. doi:10.1038/382168a0. PMID 8700207. S2CID 4286144.
^ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.
^ "Entrez Gene: NPY5R neuropeptide Y receptor Y5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164129 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044014 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8700207-5] Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL (Jul 1996). "A receptor subtype involved in neuropeptide-Y-induced food intake". Nature. 382 (6587): 168–71. Bibcode:1996Natur.382..168G. doi:10.1038/382168a0. PMID 8700207. S2CID 4286144.

[pmid9417917-6] Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.

[entrez-7] "Entrez Gene: NPY5R neuropeptide Y receptor Y5".

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