The neuropeptide FF receptors[1] are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the pain modulatory neuropeptides AF and FF.[2]
The Neuropeptide FF receptor family is a member of the G protein-coupled receptor superfamily containing two subtypes, NPFF1 and NPFF2, which exhibit a high affinity for Neuropeptide FF (NPFF) peptides. NPFF1 is broadly distributed in the central nervous system with the highest levels found in the limbic system and the hypothalamus. NPFF2 is present in high density, particularly in mammals in the superficial layers of the spinal cord where it is involved in nociception and modulation of opioid functions. These receptors participate to the modulation of opioid receptor function in the brain and spinal cord, and can either reduce or increase opioid receptor function depending which tissue they are released in, reflecting a complex role for neuropeptide FF in pain responses.
[3][4][5][6][7]
NPFF receptors are coupled to G proteins and regulate adenylyl cyclase in recombinant cell lines (CHO, HEK 293, SH-SY5Y). NPFF receptors are also coupled to voltage-gated N-type Ca2+ channels.
^Parker RM, Copeland NG, Eyre HJ, Liu M, Gilbert DJ, Crawford J, Couzens M, Sutherland GR, Jenkins NA, Herzog H (2000). "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family". Brain Res. Mol. Brain Res. 77 (2): 199–208. doi:10.1016/S0169-328X(00)00052-8. PMID 10837915.
^Elshourbagy NA, Ames RS, Fitzgerald LR, Foley JJ, Chambers JK, Szekeres PG, Evans NA, Schmidt DB, Buckley PT, Dytko GM, Murdock PR, Milligan G, Groarke DA, Tan KB, Shabon U, Nuthulaganti P, Wang DY, Wilson S, Bergsma DJ, Sarau HM (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc.M004515200. PMID 10851242.
^Yang HY, Iadarola MJ (May 2006). "Modulatory roles of the NPFF system in pain mechanisms at the spinal level". Peptides. 27 (5): 943–52. doi:10.1016/j.peptides.2005.06.030. PMID 16443306. S2CID 2197210.
^Roumy M, Lorenzo C, Mazères S, Bouchet S, Zajac JM, Mollereau C (March 2007). "Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity". The Journal of Biological Chemistry. 282 (11): 8332–42. doi:10.1074/jbc.M606946200. PMID 17224450.
^Yang HY, Tao T, Iadarola MJ (February 2008). "Modulatory role of neuropeptide FF system in nociception and opiate analgesia". Neuropeptides. 42 (1): 1–18. doi:10.1016/j.npep.2007.06.004. PMID 17854890. S2CID 20901853.
^Betourne A, Familiades J, Lacassagne L, Halley H, Cazales M, Ducommun B, Lassalle JM, Zajac JM, Frances B (November 2008). "Decreased motivational properties of morphine in mouse models of cancerous- or inflammatory-chronic pain: implication of supraspinal neuropeptide FF(2) receptors" (PDF). Neuroscience. 157 (1): 12–21. doi:10.1016/j.neuroscience.2008.08.045. PMID 18804517. S2CID 31899256.
^Cline MA, Mathews DS (2008). "Anoretic effects of neuropeptide FF are mediated via central mu and kappa subtypes of opioid receptors and receptor ligands". General and Comparative Endocrinology. 159 (2–3): 125–9. doi:10.1016/j.ygcen.2008.09.001. PMID 18823989.
and 21 Related for: Neuropeptide FF receptor information
The neuropeptideFFreceptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the pain modulatory neuropeptides...
NeuropeptideFFreceptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene. NeuropeptideFFreceptor GRCh38: Ensembl release 89: ENSG00000056291...
NeuropeptideFFreceptor 1, also known as NPFF1 is a human protein, encoded by the NPFFR1 gene. NeuropeptideFFreceptor GRCh38: Ensembl release 89: ENSG00000148734...
morphine-induced analgesia. In humans, NeuropeptideFF peptides are encoded by the NPFF gene. Two genes encoding two different receptors (NPFF1 and NPFF2) and two...
Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the...
Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide...
Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene. Neuropeptide Y (endogenous agonist, non subtype selective) Peptide...
The neuropeptide S receptor (NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins which binds neuropeptide S (NPS)...
Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic...
Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene. Neuropeptide Y (endogenous agonist, non subtype selective) BWX-46...
NPFF receptors, RF9, has been reported to possess "very strong" gonadotropin-releasing effects in vivo in male and female mice. NeuropeptideFF FMRFamide...
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline)...
The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants...
acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the...
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin...
of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled...
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells. They act in cell...
Global Information