negative regulation of transcription by RNA polymerase II
transcription, DNA-templated
multicellular organism development
artery morphogenesis
forebrain development
neuron fate commitment
transcription initiation from RNA polymerase II promoter
positive regulation of transcription by RNA polymerase II
positive regulation of smooth muscle cell proliferation
regulation of developmental process
positive regulation of transcription of Notch receptor target
Notch receptor processing, ligand-dependent
negative regulation of Notch signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4854
18131
Ensembl
ENSG00000074181
ENSMUSG00000038146
UniProt
Q9UM47
Q61982
RefSeq (mRNA)
NM_000435
NM_008716
RefSeq (protein)
NP_000426
NP_032742
Location (UCSC)
Chr 19: 15.16 – 15.2 Mb
Chr 17: 32.34 – 32.39 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Neurogenic locus notch homolog protein 3(Notch 3) is a protein that in humans is encoded by the NOTCH3 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000074181 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038146 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (September 15, 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.
homolog protein 3 (Notch 3) is a protein that in humans is encoded by the NOTCH3 gene. This gene encodes the third discovered human homologue of the Drosophila...
each mutation, a consensus significant loss of beta sheet structure of the Notch3 protein has been predicted using in silico analysis. MRIs show hypointensities...
possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor...
is an inherited disorder caused by mutations in the NOTCH3 gene located on chromosome 19. NOTCH3 codes for a transmembrane protein whose function is not...
previous clinical reports, as well as a heterozygous pathogenic variant in the NOTCH3 gene. Diagnosis of Lehman syndrome may be suspected based on several distinctive...
cerebral hemorrhage with amyloidosis (Icelandic) (HCHWA-I) Cystatin C CADASIL Notch3 Alexander disease Glial fibrillary acidic protein (GFAP) Pelizaeus-Merzbacher...
Joutel, C Corpechot, A Ducros, K Vahedi, H Chabriat, P Mouton, et al. 1996. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke...
the cases of PML (caused by the JC virus), CADASIL (caused by abnormal NOTCH3 protein activity), and Krabbe disease (caused by a deficiency of the enzyme...
Williams & Wilkins. ISBN 978-0443056833. Rusanescu G, Mao J (October 2014). "Notch3 is necessary for neuronal differentiation and maturation in the adult spinal...
These familial cases are associated with mutations in either the PDGFRB or NOTCH3 gene. However, most IMF cases have no family history of the disease but...
disorder is known to be caused by mutations in germline variants, PDGFRB and NOTCH3, which may be generationally-inherited through autosomal dominant and recessive...
"Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc...
programmed cell death. The following is the list of known dependence receptors: Notch3 Kremen1 DCC (Deleted in Colorectal Carcinoma) UNC5 receptors (UNC5A, UNC5B...
"Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc...