CDX2 information

CDX2
Identifiers
Aliases	CDX2, CDX-3, CDX2/AS, CDX3, caudal type homeobox 2, Cdx2
External IDs	OMIM: 600297; MGI: 88361; HomoloGene: 968; GeneCards: CDX2; OMA:CDX2 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	27,969,315 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	147,244,080 bp
RNA expression pattern
	Top expressed in
	rectum; ; duodenum; ; appendix; ; jejunal mucosa; ; body of pancreas; ; islet of Langerhans; ; smooth muscle tissue; ; liver; ; kidney; ; prostate;
	Top expressed in
	Paneth cell; ; crypt of lieberkuhn of small intestine; ; primitive streak; ; ileum; ; jejunum; ; duodenum; ; Epithelium of large intestine; ; left colon; ; morula; ; urethra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; methyl-CpG binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	transcription repressor complex; nucleoplasm; condensed nuclear chromosome; nucleus; protein-containing complex;
Biological process	pattern specification process; cell differentiation; regulation of transcription, DNA-templated; regulation of somitogenesis; somatic stem cell population maintenance; endosome to lysosome transport; placenta development; regulation of transcription by RNA polymerase II; labyrinthine layer development; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; multicellular organism development; blood vessel development; trophectodermal cell differentiation; establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of cell differentiation; intestinal epithelial cell differentiation; positive regulation of cell population proliferation; animal organ morphogenesis; anterior/posterior axis specification; blastocyst development; anterior/posterior pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	1045
	12591
	ENSG00000165556
	ENSMUSG00000029646
	Q99626
	P43241
	NM_001265; NM_001354700
	NM_007673
	NP_001256; NP_001341629
	NP_031699
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The CDX2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells,^[5]^[6] playing an essential role in the development and function of the digestive system. CDX2 is part of the ParaHox gene cluster, a group of three highly conserved developmental genes present in most vertebrate species.^[7] Together with CDX1 and CDX4, CDX2 is one of three caudal-related genes in the human genome.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165556 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029646 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI (Nov 1994). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics. 24 (2): 403–4. doi:10.1006/geno.1994.1639. PMID 7698771.
^ Cite error: The named reference :0 was invoked but never defined (see the help page).
^ Brooke NM, Garcia-Fernàndez J, Holland PW (1998). "The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster". Nature. 392 (6679): 920–922. Bibcode:1998Natur.392..920B. doi:10.1038/31933. ISSN 0028-0836. PMID 9582071. S2CID 4398740.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165556 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029646 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7698771-5] German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI (Nov 1994). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics. 24 (2): 403–4. doi:10.1006/geno.1994.1639. PMID 7698771.

[:0-6] Cite error: The named reference :0 was invoked but never defined (see the help page).

[7] Brooke NM, Garcia-Fernàndez J, Holland PW (1998). "The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster". Nature. 392 (6679): 920–922. Bibcode:1998Natur.392..920B. doi:10.1038/31933. ISSN 0028-0836. PMID 9582071. S2CID 4398740.

CDX2 information

and 26 Related for: CDX2 information

CDX2

Inner cell mass

Blastocyst

Homeotic gene

Cdx protein family

Intestinal metaplasia

Animal embryonic development

Human embryonic development

Cdx

Insulin regulatory sequence

Urachal cancer

Pseudomyxoma peritonei

Asiatic cheetah

Homeobox

The Mock Turtles

List of human transcription factors

List of intestinal epithelial differentiation genes

Old Europa Cafe discography

Neuroendocrine tumor

CDX1

ParaHox

Keratin 20

Das Lied von der Erde

SOX2

Cadmium hydroxide

Colossal Youth