Mouse mammary tumor virus (MMTV) is a milk-transmitted retrovirus like the HTL viruses, HI viruses, and BLV. It belongs to the genus Betaretrovirus. MMTV was formerly known as Bittner virus, and previously the "milk factor", referring to the extra-chromosomal vertical transmission of murine breast cancer by adoptive nursing, demonstrated in 1936, by John Joseph Bittner while working at the Jackson Laboratory in Bar Harbor, Maine. Bittner established the theory that a cancerous agent, or "milk factor", could be transmitted by cancerous mothers to young mice from a virus in their mother's milk.[1][2] The majority of mammary tumors in mice are caused by mouse mammary tumor virus.
^Bittner, J. J. (1936). "Some Possible Effects of Nursing on the Mammary Gland Tumor Incidence in Mice". Science. 84 (2172): 162. Bibcode:1936Sci....84..162B. doi:10.1126/science.84.2172.162. PMID 17793252. S2CID 31163817.
^"Medicine: Cancer Virus". TIME magazine. 18 March 1946. Archived from the original on February 19, 2011.
and 26 Related for: Mouse mammary tumor virus information
Mousemammarytumorvirus (MMTV) is a milk-transmitted retrovirus like the HTL viruses, HI viruses, and BLV. It belongs to the genus Betaretrovirus. MMTV...
also known as Human mammarytumorvirus, or Mousemammarytumor-like virus is the human homologue of the Mousemammarytumorvirus (MMTV). The nomenclature...
A mammarytumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are not spayed, but they are...
Breast cancer metastatic mouse models are experimental approaches in which mice are genetically manipulated to develop a mammarytumor leading to distant focal...
For example, mice have mousemammarytumorvirus (MMTV), which is a retrovirus. This virus passes to newborn mice through mammary milk. When they are 6...
the mousemammarytumorvirus promoter). The activated oncogene significantly increases the mouse's susceptibility to cancer, and thus makes the mouse a...
1936 John Joseph Bittner identified the mousemammarytumorvirus, an "extrachromosomal factor" (i.e. virus) that could be transmitted between laboratory...
viruses of mice; some primate and sheep viruses are the type D.[citation needed] Examples are Mousemammarytumorvirus, enzootic nasal tumorvirus (ENTV-1...
A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune...
research may involve: [Inhibition of] tumor induction due to polyoma virus, and mammarytumorvirus in the mouse, and [interference] with transplantable...
et al. (2009). "Priming of protective T cell responses against virus-induced tumors in mice with human immune system components". J. Exp. Med. 206 (6):...
with mousemammarytumorvirus in order to mutate mouse genes to see which mutated genes could cause breast tumors. They identified a new mouse proto-oncogene...
African rat, or the African soft-furred mouse. The Natal multimammate rat is the natural host of the Lassa fever virus. It is found in Africa south of the...
for assessing prognosis.[medical citation needed] Mammarytumor for breast cancer in other animals Mouse models of breast cancer metastasis Metaplastic breast...
transcription factors determines transcriptional synergism at the mousemammarytumorvirus promoter". The Journal of Biological Chemistry. 274 (38): 26713–26719...
P56 and the Int6 Protein Encoded by a Locus of Insertion of the MouseMammaryTumorVirus". J. Virol. 74 (4): 1892–9. doi:10.1128/JVI.74.4.1892-1899.2000...
PMID 22617420. Nusse, R; Varmus, HE (November 1982). "Many tumors induced by the mousemammarytumorvirus contain a provirus integrated in the same region of...
double-stranded DNA viruses. MTag is expressed early in the infectious cycle along with two other related proteins, the small tumor antigen and large tumor antigen...
Translationally controlled tumor protein was first discovered in 1989 as a cDNA sequence obtained from a human mammary carcinoma cDNA library with proves...
low-stringency hybridization with probes for the mammarytumorvirus of the mouse and A particle intracutaneous mouse. In 2015 Grow et al. demonstrated that HERV-K...
transmission of retrovirus. In the paper by Kane, et al., they found the mousemammarytumorvirus is transmitted most efficiently through bacteria colonized mucosal...
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